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(6S)-5,6,7,8-tetrahydrofolate(2-)
Dianion of (6S)-5,6,7,8-tetrahydrofolic acid arising from deprotonation of both carboxylic acid functions.

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04. Bioactive Capabilities of Specific Chemicals : Ligases [EC:6] > Forming carbon—nitrogen bonds [EC:6.3] > Other Carbon-Nitrogen Ligases [EC:6.3.4] > Formate--tetrahydrofolate ligase [EC:6.3.4.3]
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04. Bioactive Capabilities of Specific Chemicals  
04. Bioactive Capabilities of Specific Chemicals
 Oxidoreductases [EC:1] (1697) 
 Acting on the CH-NH group of donors [EC:1.5] (120) 
 With NAD or NADP as acceptor [EC:1.5.1] (77) 
 Dihydrofolate reductase [EC:1.5.1.3] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Formyltetrahydrofolate dehydrogenase [EC:1.5.1.6] (7) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Transferases [EC:2] (1441) 
 Transferring one-carbon groups [EC:2.1] (318) 
 Methyltransferases [EC:2.1.1] (279) 
 Methionine synthase [EC:2.1.1.13] (4) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Trimethylsulfonium--tetrahydrofolate N-methyltransferase [EC:2.1.1.19] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Thymidylate synthase (FAD) [EC:2.1.1.148] (7) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Dimethylsulfoniopropionate demethylase [EC:2.1.1.269] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Hydroxymethyl-, Formyl- and Related Transferases [EC:2.1.2] (26) 
 Glycine hydroxymethyltransferase [EC:2.1.2.1] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.3] (4) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Glycine formimidoyltransferase [EC:2.1.2.4] (4) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Glutamate formimidoyltransferase [EC:2.1.2.5] (7) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 D-alanine 2-hydroxymethyltransferase [EC:2.1.2.7] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Deoxycytidylate 5-hydroxymethyltransferase [EC:2.1.2.8] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Aminomethyltransferase [EC:2.1.2.10] (4) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 UDP-4-amino-4-deoxy-L-arabinose formyltransferase [EC:2.1.2.13] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Hydrolases [EC:3] (824) 
 Acting on carbon-nitrogen bonds, other than peptide bonds [EC:3.5] (303) 
 In linear amides [EC:3.5.1] (174) 
 Formyltetrahydrofolate deformylase [EC:3.5.1.10] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 Ligases [EC:6] (206) 
 Forming carbon—nitrogen bonds [EC:6.3] (134) 
 Other Carbon-Nitrogen Ligases [EC:6.3.4] (44) 
 Formate--tetrahydrofolate ligase [EC:6.3.4.3] (5) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
08. Chemical Category 
08. Chemical Category
 ion [CHEBI:24870] (4391) 
 anion [CHEBI:22563] (3454) 
 organic anion [CHEBI:25696] (3155) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 polyatomic anion [CHEBI:33273] (2028) 
 oxoanion [CHEBI:35406] (1950) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 organic ion [CHEBI:25699] (3577) 
 organic anion [CHEBI:25696] (3155) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 polyatomic ion [CHEBI:36358] (2633) 
 polyatomic anion [CHEBI:33273] (2028) 
 oxoanion [CHEBI:35406] (1950) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 main group molecular entity [CHEBI:33579] (25650) 
 p-block molecular entity [CHEBI:33675] (25343) 
 chalcogen molecular entity [CHEBI:33304] (15225) 
 oxygen molecular entity [CHEBI:25806] (14414) 
 oxide [CHEBI:25741] (2086) 
 oxoanion [CHEBI:35406] (1950) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 organic ion [CHEBI:25699] (3577) 
 organic anion [CHEBI:25696] (3155) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 polyatomic entity [CHEBI:36357] (18777) 
 polyatomic ion [CHEBI:36358] (2633) 
 polyatomic anion [CHEBI:33273] (2028) 
 oxoanion [CHEBI:35406] (1950) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 heteroatomic molecular entity [CHEBI:37577] (13672) 
 oxide [CHEBI:25741] (2086) 
 oxoanion [CHEBI:35406] (1950) 
 carboxylic acid anion [CHEBI:29067] (1731) 
 dicarboxylic acid anion [CHEBI:35693] (337) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
 carboxylic acid dianion [CHEBI:38716] (236) 
 dicarboxylic acid dianion [CHEBI:28965] (234) 
 (6S)-5,6,7,8-tetrahydrofolate(2-) [CHEBI:57453] (1)
ChEBI Compound Accession Identifier:   [CHEBI:57453]
ChEBI Compound Description:   Dianion of (6S)-5,6,7,8-tetrahydrofolic acid arising from deprotonation of both carboxylic acid functions.
ChEBI Compound Identification Number:   57453
ChEBI InChI Value:   InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1
ChEBI InChIKey Value:   MSTNYGQPCMXVAQ-RYUDHWBXSA-L
ChEBI Compound Name:   (6S)-5,6,7,8-tetrahydrofolate(2-)
ChEBI SMILES Value:   Nc1nc2NC[C@H](CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)Nc2c(=O)[nH]1
ChEBI Substance ID:   99319144
ChEBI URL:   ChEBI:57453
ChemSpider ID:   NS
Ontomatica Chemical Accession Key (OnChAKey):   MSTNYGQPCMXVAQ_RYUDHWBXSA_L_000_000000
PubChem Compound ID:   25790919