Item 1 of 1 (back to results) enalapril maleate The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.

Current search: 03. Biological Effects of Specific Chemicals: biochemical uses [CHEBI:52206] > enzyme inhibitor [CHEBI:23924] > angiotensin-converting enzyme inhibitor [CHEBI:35457] > enalapril maleate [CHEBI:4785] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   enzyme inhibitor [CHEBI:23924] (825)   angiotensin-converting enzyme inhibitor [CHEBI:35457] (14)   enalapril maleate [CHEBI:4785] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antihypertensive agent [CHEBI:35674] (104)   enalapril maleate [CHEBI:4785] (1)  prodrug [CHEBI:50266] (88)   enalapril maleate [CHEBI:4785] (1) 08. Chemical Category  08. Chemical Category  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   maleate salt [CHEBI:50221] (31)   enalapril maleate [CHEBI:4785] (1) ChEBI Compound Accession Identifier:   [CHEBI:4785] ChEBI Compound Description:   The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. ChEBI Compound Identification Number:   4785 ChEBI InChI Value:   "InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16-,17-;/m0./s1" ChEBI InChIKey Value:   OYFJQPXVCSSHAI-QFPUQLAESA-N ChEBI Compound Name:   enalapril maleate ChEBI SMILES Value:   OC(=O)\\C=C/C(O)=O.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O ChEBI Substance ID:   99319103 ChEBI URL:   ChEBI:4785 ChemSpider ID:   4534997 Ontomatica Chemical Accession Key (OnChAKey):   OYFJQPXVCSSHAI_QFPUQLAESA_N_000_000000 PubChem Compound ID:   5388961