Item 1 of 1 (back to results) dysidine A sesquiterpenoid isolated from the sponge Dysidea sp. that is 5-amino-2-hydroxy-3-methyl-1,4-benzoquinone in which one of the hydrogens of the methyl group is replaced by a 1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-2-yl group and one of the hydrogens attached to the nitrogen is replaced by a 2-sulfoethyl group. Dysidine selectively inhibits human synovial phospholipase A2 (EC 3.1.1.4) with an IC50 = 2.0 muM.

Current search: 03. Biological Effects of Specific Chemicals: biochemical uses [CHEBI:52206] > metabolite [CHEBI:25212] > secondary metabolite [CHEBI:26619] > dysidine [CHEBI:65816] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   enzyme inhibitor [CHEBI:23924] (825)   phospholipase A2 inhibitor [CHEBI:50469] (3)   dysidine [CHEBI:65816] (1)  metabolite [CHEBI:25212] (2692)   secondary metabolite [CHEBI:26619] (2225)   dysidine [CHEBI:65816] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   s-block molecular entity [CHEBI:33674] (7287)   hydrogen molecular entity [CHEBI:33608] (6932)   hydroxides [CHEBI:24651] (5641)   organic hydroxy compound [CHEBI:33822] (3050)   enol [CHEBI:33823] (52)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   dysidine [CHEBI:65816] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   hydroxides [CHEBI:24651] (5641)   organic hydroxy compound [CHEBI:33822] (3050)   enol [CHEBI:33823] (52)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   ketone [CHEBI:17087] (1288)   cyclic ketone [CHEBI:3992] (644)   quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  sulfur molecular entity [CHEBI:26835] (1541)   organosulfur compound [CHEBI:33261] (1005)   organosulfonic acid [CHEBI:33551] (119)   dysidine [CHEBI:65816] (1)  sulfur oxoacid derivative [CHEBI:33424] (628)   sulfonic acid derivative [CHEBI:33552] (393)   organosulfonic acid [CHEBI:33551] (119)   dysidine [CHEBI:65816] (1)  organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   organosulfonic acid [CHEBI:33551] (119)   dysidine [CHEBI:65816] (1)  organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   ketone [CHEBI:17087] (1288)   cyclic ketone [CHEBI:3992] (644)   quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   lipid [CHEBI:18059] (3532)   isoprenoid [CHEBI:24913] (1402)   terpenoid [CHEBI:26873] (1099)   sesquiterpenoid [CHEBI:26658] (209)   dysidine [CHEBI:65816] (1)  isoprenoid [CHEBI:24913] (1402)   terpenoid [CHEBI:26873] (1099)   sesquiterpenoid [CHEBI:26658] (209)   dysidine [CHEBI:65816] (1)  heteroorganic entity [CHEBI:33285] (15197)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   dysidine [CHEBI:65816] (1)  organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   organosulfonic acid [CHEBI:33551] (119)   dysidine [CHEBI:65816] (1)  organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   ketone [CHEBI:17087] (1288)   cyclic ketone [CHEBI:3992] (644)   quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  organic hydroxy compound [CHEBI:33822] (3050)   enol [CHEBI:33823] (52)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   dysidine [CHEBI:65816] (1)  organic molecule [CHEBI:72695] (11399)   organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   ketone [CHEBI:17087] (1288)   cyclic ketone [CHEBI:3992] (644)   quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   organic molecule [CHEBI:72695] (11399)   organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   ketone [CHEBI:17087] (1288)   cyclic ketone [CHEBI:3992] (644)   quinone [CHEBI:36141] (209)   benzoquinones [CHEBI:22729] (30)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  heteroatomic molecular entity [CHEBI:37577] (13672)   hydroxides [CHEBI:24651] (5641)   organic hydroxy compound [CHEBI:33822] (3050)   enol [CHEBI:33823] (52)   2-hydroxy-1,4-benzoquinones [CHEBI:67273] (3)   dysidine [CHEBI:65816] (1)  oxoacid derivative [CHEBI:33241] (3254)   sulfur oxoacid derivative [CHEBI:33424] (628)   sulfonic acid derivative [CHEBI:33552] (393)   organosulfonic acid [CHEBI:33551] (119)   dysidine [CHEBI:65816] (1) ChEBI Compound Accession Identifier:   [CHEBI:65816] ChEBI Compound Description:   A sesquiterpenoid isolated from the sponge Dysidea sp. that is 5-amino-2-hydroxy-3-methyl-1,4-benzoquinone in which one of the hydrogens of the methyl group is replaced by a 1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-2-yl group and one of the hydrogens attached to the nitrogen is replaced by a 2-sulfoethyl group. Dysidine selectively inhibits human synovial phospholipase A2 (EC 3.1.1.4) with an IC50 = 2.0 muM. ChEBI Compound Identification Number:   65816 ChEBI InChI Value:   InChI=1S/C23H33NO6S/c1-14-6-5-7-17-15(2)22(3,8-9-23(14,17)4)13-16-20(26)18(12-19(25)21(16)27)24-10-11-31(28,29)30/h6,12,15,17,24,27H,5,7-11,13H2,1-4H3,(H,28,29,30)/t15-,17+,22-,23-/m1/s1 ChEBI InChIKey Value:   HHKUTKBQEPDLMV-CIVZFWGOSA-N ChEBI Compound Name:   dysidine ChEBI SMILES Value:   [H][C@@]12CCC=C(C)[C@@]1(C)CC[C@](C)(CC1=C(O)C(=O)C=C(NCCS(O)(=O)=O)C1=O)[C@@H]2C ChEBI Substance ID:   160645210 ChEBI URL:   ChEBI:65816 ChemSpider ID:   10214288 Ontomatica Chemical Accession Key (OnChAKey):   HHKUTKBQEPDLMV_CIVZFWGOSA_N_000_000000 PubChem Compound ID:   10321583