Item 1 of 1 (back to results) cilastatin sodium The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administered with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.

Current search: 03. Biological Effects of Specific Chemicals: biochemical uses [CHEBI:52206] > enzyme inhibitor [CHEBI:23924] > protease inhibitor [CHEBI:37670] > cilastatin sodium [CHEBI:59511] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   enzyme inhibitor [CHEBI:23924] (825)   protease inhibitor [CHEBI:37670] (37)   cilastatin sodium [CHEBI:59511] (1)  dipeptidase inhibitor [CHEBI:59499] (2)   cilastatin sodium [CHEBI:59511] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   s-block molecular entity [CHEBI:33674] (7287)   alkali metal molecular entity [CHEBI:33296] (279)   sodium molecular entity [CHEBI:26712] (216)   sodium salt [CHEBI:26714] (213)   organic sodium salt [CHEBI:38700] (187)   cilastatin sodium [CHEBI:59511] (1)  alkali metal salt [CHEBI:35479] (248)   sodium salt [CHEBI:26714] (213)   organic sodium salt [CHEBI:38700] (187)   cilastatin sodium [CHEBI:59511] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic sodium salt [CHEBI:38700] (187)   cilastatin sodium [CHEBI:59511] (1)  alkali metal salt [CHEBI:35479] (248)   sodium salt [CHEBI:26714] (213)   organic sodium salt [CHEBI:38700] (187)   cilastatin sodium [CHEBI:59511] (1) ChEBI Compound Accession Identifier:   [CHEBI:59511] ChEBI Compound Description:   The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administered with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products. ChEBI Compound Identification Number:   59511 ChEBI InChI Value:   "InChI=1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1" ChEBI InChIKey Value:   QXPBTTUOVWMPJN-QBNHLFMHSA-M ChEBI Compound Name:   cilastatin sodium ChEBI SMILES Value:   [Na+].CC1(C)C[C@@H]1C(=O)N\C(C(O)=O)=C/CCCCSC[C@H](N)C([O-])=O ChEBI Substance ID:   93581446 ChEBI URL:   ChEBI:59511 ChemSpider ID:   5293165 Ontomatica Chemical Accession Key (OnChAKey):   QXPBTTUOVWMPJN_QBNHLFMHSA_M_000_000000 PubChem Compound ID:   45480603