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busulfan
A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.


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03. Biological Effects of Specific Chemicals: aetiopathogenetic uses [CHEBI:52209] > genotoxin [CHEBI:50902] > mutagen [CHEBI:25435] > alkylating agent [CHEBI:22333] > busulfan [CHEBI:28901]
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03. Biological Effects of Specific Chemicals 
03. Biological Effects of Specific Chemicals
 aetiopathogenetic uses [CHEBI:52209] (178) 
 genotoxin [CHEBI:50902] (78) 
 mutagen [CHEBI:25435] (74) 
 alkylating agent [CHEBI:22333] (29) 
 busulfan [CHEBI:28901] (1)
 carcinogenic agent [CHEBI:50903] (40) 
 busulfan [CHEBI:28901] (1)
 teratogenic agent [CHEBI:50905] (12) 
 busulfan [CHEBI:28901] (1)
05. Industrial Uses 
05. Industrial Uses
 pesticide [CHEBI:25944] (211) 
 chemosterilant [CHEBI:23092] (5) 
 insect sterilant [CHEBI:67105] (5) 
 busulfan [CHEBI:28901] (1)
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 antineoplastic agent [CHEBI:35610] (760) 
 busulfan [CHEBI:28901] (1)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 p-block molecular entity [CHEBI:33675] (25343) 
 chalcogen molecular entity [CHEBI:33304] (15225) 
 sulfur molecular entity [CHEBI:26835] (1541) 
 organosulfur compound [CHEBI:33261] (1005) 
 methanesulfonates [CHEBI:48544] (33) 
 methanesulfonate ester [CHEBI:25223] (5) 
 busulfan [CHEBI:28901] (1)
 organochalcogen compound [CHEBI:36962] (11874) 
 organosulfur compound [CHEBI:33261] (1005) 
 methanesulfonates [CHEBI:48544] (33) 
 methanesulfonate ester [CHEBI:25223] (5) 
 busulfan [CHEBI:28901] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organochalcogen compound [CHEBI:36962] (11874) 
 organosulfur compound [CHEBI:33261] (1005) 
 methanesulfonates [CHEBI:48544] (33) 
 methanesulfonate ester [CHEBI:25223] (5) 
 busulfan [CHEBI:28901] (1)
ChEBI Compound Accession Identifier  [CHEBI:28901]
ChEBI Compound Description  A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
ChEBI Compound Identification Number  28901
ChEBI InChI Value  InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
ChEBI InChIKey Value  COVZYZSDYWQREU-UHFFFAOYSA-N
ChEBI Compound Name  busulfan
ChEBI SMILES Value  CS(=O)(=O)OCCCCOS(C)(=O)=O
ChEBI Substance ID  11533211
ChEBI URL  ChEBI:28901
ChemSpider ID  2384
Ontomatica Chemical Accession Key (OnChAKey)  COVZYZSDYWQREU_UHFFFAOYSA_N_000_000000
PubChem Compound ID  2478