Item 1 of 1 (back to results) fenfluramine hydrochloride The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > serotonergic drug [CHEBI:48278] > serotonergic agonist [CHEBI:35941] > fenfluramine hydrochloride [CHEBI:59729] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   serotonergic drug [CHEBI:48278] (109)   serotonergic agonist [CHEBI:35941] (41)   fenfluramine hydrochloride [CHEBI:59729] (1)  serotonin uptake inhibitor [CHEBI:50949] (21)   fenfluramine hydrochloride [CHEBI:59729] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   appetite regulator [CHEBI:50780] (13)   appetite depressant [CHEBI:50507] (12)   fenfluramine hydrochloride [CHEBI:59729] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   chlorine molecular entity [CHEBI:23117] (884)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   fenfluramine hydrochloride [CHEBI:59729] (2)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   fenfluramine hydrochloride [CHEBI:59729] (2)  pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   ammonium compound [CHEBI:35276] (129)   organoammonium salt [CHEBI:46850] (104)   fenfluramine hydrochloride [CHEBI:59729] (2)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic halide salt [CHEBI:51069] (386)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   fenfluramine hydrochloride [CHEBI:59729] (2)  halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   fenfluramine hydrochloride [CHEBI:59729] (2)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   fenfluramine hydrochloride [CHEBI:59729] (2) ChEBI Compound Accession Identifier:   [CHEBI:59729] ChEBI Compound Description:   The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. ChEBI Compound Identification Number:   59729 ChEBI InChI Value:   "InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H" ChEBI InChIKey Value:   ZXKXJHAOUFHNAS-UHFFFAOYSA-N ChEBI Compound Name:   fenfluramine hydrochloride ChEBI SMILES Value:   [Cl-].CC[NH2+]C(C)Cc1cccc(c1)C(F)(F)F ChEBI Substance ID:   99319709 ChEBI URL:   ChEBI:59729 ChemSpider ID:   82580 Ontomatica Chemical Accession Key (OnChAKey):   ZXKXJHAOUFHNAS_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   43834422