Item 1 of 1 (back to results) 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide A benzamide obtained by formal condensation of the carboxy group of 4-fluorobenzoic acid with the primary amino group of 2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethylamine. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > serotonergic drug [CHEBI:48278] > serotonergic agonist [CHEBI:35941] > 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   serotonergic drug [CHEBI:48278] (109)   serotonergic agonist [CHEBI:35941] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   central nervous system drug [CHEBI:35470] (217)   psychotropic drug [CHEBI:35471] (130)   tranquilizing drug [CHEBI:35473] (83)   anxiolytic drug [CHEBI:35474] (31)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   fluorine molecular entity [CHEBI:24062] (288)   organofluorine compound [CHEBI:37143] (275)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  halide [CHEBI:37578] (1402)   organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   amide [CHEBI:32988] (1863)   primary amide [CHEBI:33256] (1586)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   arenecarboxamide [CHEBI:22645] (45)   benzamides [CHEBI:22702] (45)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbocyclic compound [CHEBI:33598] (1130)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic aromatic compound [CHEBI:33659] (3593)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   homocyclic compound [CHEBI:33597] (1134)   carbocyclic compound [CHEBI:33598] (1130)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  homopolycyclic compound [CHEBI:35295] (493)   carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  polycyclic compound [CHEBI:33635] (4078)   homopolycyclic compound [CHEBI:35295] (493)   carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  bicyclic compound [CHEBI:33636] (1511)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  aromatic compound [CHEBI:33655] (3799)   organic aromatic compound [CHEBI:33659] (3593)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  monocyclic compound [CHEBI:33661] (2007)   heteromonocyclic compound [CHEBI:33670] (2004)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbocyclic compound [CHEBI:33598] (1130)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic aromatic compound [CHEBI:33659] (3593)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  heteromonocyclic compound [CHEBI:33670] (2004)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organic heteromonocyclic compound [CHEBI:25693] (2004)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   piperazines [CHEBI:26144] (111)   N-alkylpiperazine [CHEBI:46845] (56)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  N-arylpiperazine [CHEBI:46848] (41)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbocyclic compound [CHEBI:33598] (1130)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  carbopolycyclic compound [CHEBI:35294] (493)   carbobicyclic compound [CHEBI:36785] (199)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  organic aromatic compound [CHEBI:33659] (3593)   benzenoid aromatic compound [CHEBI:33836] (730)   naphthalenes [CHEBI:25477] (89)   alkyloxynaphthalene [CHEBI:48850] (13)   methoxynaphthalene [CHEBI:48851] (13)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1)  heteroatomic molecular entity [CHEBI:37577] (13672)   halide [CHEBI:37578] (1402)   organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide [CHEBI:64101] (1) ChEBI Compound Accession Identifier:   [CHEBI:64101] ChEBI Compound Description:   A benzamide obtained by formal condensation of the carboxy group of 4-fluorobenzoic acid with the primary amino group of 2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethylamine. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. ChEBI Compound Identification Number:   64101 ChEBI InChI Value:   InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29) ChEBI InChIKey Value:   IFMQODYDAUKKEN-UHFFFAOYSA-N ChEBI Compound Name:   4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide ChEBI SMILES Value:   COc1ccc2cccc(N3CCN(CCNC(=O)c4ccc(F)cc4)CC3)c2c1 ChEBI Substance ID:   135610559 ChEBI URL:   ChEBI:64101 ChemSpider ID:   116528 Ontomatica Chemical Accession Key (OnChAKey):   IFMQODYDAUKKEN_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   131906