Item 1 of 1 (back to results) SB 224289 hydrochloride A hydrochloride that is the monohydrochloride salt of SB 224289. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > serotonergic drug [CHEBI:48278] > serotonergic antagonist [CHEBI:48279] > SB 224289 hydrochloride [CHEBI:64067] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   serotonergic drug [CHEBI:48278] (109)   serotonergic antagonist [CHEBI:48279] (52)   SB 224289 hydrochloride [CHEBI:64067] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   prodrug [CHEBI:50266] (88)   SB 224289 hydrochloride [CHEBI:64067] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   chlorine molecular entity [CHEBI:23117] (884)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   SB 224289 hydrochloride [CHEBI:64067] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   SB 224289 hydrochloride [CHEBI:64067] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic halide salt [CHEBI:51069] (386)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   SB 224289 hydrochloride [CHEBI:64067] (1)  halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   SB 224289 hydrochloride [CHEBI:64067] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   SB 224289 hydrochloride [CHEBI:64067] (1) ChEBI Compound Accession Identifier:   [CHEBI:64067] ChEBI Compound Description:   A hydrochloride that is the monohydrochloride salt of SB 224289. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo. ChEBI Compound Identification Number:   64067 ChEBI InChI Value:   "InChI=1S/C32H32N4O3.ClH/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32;/h4-9,16-18H,10-15,19H2,1-3H3;1H" ChEBI InChIKey Value:   GKGKBZYMDILCOF-UHFFFAOYSA-N ChEBI Compound Name:   SB 224289 hydrochloride ChEBI SMILES Value:   Cl.CN1CCC2(CC1)COc1cc3CCN(C(=O)c4ccc(cc4)-c4ccc(cc4C)-c4noc(C)n4)c3cc21 ChEBI Substance ID:   135610878 ChEBI URL:   ChEBI:64067 ChemSpider ID:   9401769 Ontomatica Chemical Accession Key (OnChAKey):   GKGKBZYMDILCOF_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   11226716