Item 1 of 1 (back to results) fenfluramine 1-Phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > serotonergic drug [CHEBI:48278] > serotonin uptake inhibitor [CHEBI:50949] > fenfluramine [CHEBI:5000] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   serotonergic drug [CHEBI:48278] (109)   serotonergic agonist [CHEBI:35941] (41)   fenfluramine [CHEBI:5000] (1)  serotonin uptake inhibitor [CHEBI:50949] (21)   fenfluramine [CHEBI:5000] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   appetite regulator [CHEBI:50780] (13)   appetite depressant [CHEBI:50507] (12)   fenfluramine [CHEBI:5000] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   fenfluramine [CHEBI:5000] (3)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   fenfluramine [CHEBI:5000] (3)  organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   fenfluramine [CHEBI:5000] (3) ChEBI Compound Accession Identifier:   [CHEBI:5000] ChEBI Compound Description:   1-Phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. ChEBI Compound Identification Number:   5000 ChEBI InChI Value:   InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3 ChEBI InChIKey Value:   DBGIVFWFUFKIQN-UHFFFAOYSA-N ChEBI Compound Name:   fenfluramine ChEBI SMILES Value:   CCNC(C)Cc1cccc(c1)C(F)(F)F ChEBI Substance ID:   99313648 ChEBI URL:   ChEBI:5000 ChemSpider ID:   NS Ontomatica Chemical Accession Key (OnChAKey):   DBGIVFWFUFKIQN_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   3337