Item 1 of 1 (back to results) pergolide A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > dopaminergic agent [CHEBI:48560] > dopamine agonist [CHEBI:51065] > pergolide [CHEBI:63617] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   dopaminergic agent [CHEBI:48560] (99)   dopamine agonist [CHEBI:51065] (26)   pergolide [CHEBI:63617] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antidyskinesia agent [CHEBI:66956] (43)   antiparkinson drug [CHEBI:48407] (41)   pergolide [CHEBI:63617] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   diamine [CHEBI:23666] (39)   pergolide [CHEBI:63617] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organonitrogen compound [CHEBI:35352] (6705)   organic amino compound [CHEBI:50047] (2472)   diamine [CHEBI:23666] (39)   pergolide [CHEBI:63617] (1)  organic amino compound [CHEBI:50047] (2472)   diamine [CHEBI:23666] (39)   pergolide [CHEBI:63617] (1) ChEBI Compound Accession Identifier:   [CHEBI:63617] ChEBI Compound Description:   A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. ChEBI Compound Identification Number:   63617 ChEBI InChI Value:   InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 ChEBI InChIKey Value:   YEHCICAEULNIGD-MZMPZRCHSA-N ChEBI Compound Name:   pergolide ChEBI SMILES Value:   [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC ChEBI Substance ID:   135610131 ChEBI URL:   ChEBI:63617 ChemSpider ID:   43503 Ontomatica Chemical Accession Key (OnChAKey):   YEHCICAEULNIGD_MZMPZRCHSA_N_000_000000 PubChem Compound ID:   47811