Item 1 of 1 (back to results) eribulin mesylate A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > tubulin modulator [CHEBI:60832] > microtubule-destabilising agent [CHEBI:61951] > eribulin mesylate [CHEBI:70710] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   tubulin modulator [CHEBI:60832] (12)   microtubule-destabilising agent [CHEBI:61951] (9)   eribulin mesylate [CHEBI:70710] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antineoplastic agent [CHEBI:35610] (760)   eribulin mesylate [CHEBI:70710] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   chalcogen molecular entity [CHEBI:33304] (15225)   sulfur molecular entity [CHEBI:26835] (1541)   organosulfur compound [CHEBI:33261] (1005)   methanesulfonates [CHEBI:48544] (33)   methanesulfonate salt [CHEBI:38037] (28)   eribulin mesylate [CHEBI:70710] (1)  organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   methanesulfonates [CHEBI:48544] (33)   methanesulfonate salt [CHEBI:38037] (28)   eribulin mesylate [CHEBI:70710] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   methanesulfonates [CHEBI:48544] (33)   methanesulfonate salt [CHEBI:38037] (28)   eribulin mesylate [CHEBI:70710] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organosulfonate salt [CHEBI:64382] (37)   methanesulfonate salt [CHEBI:38037] (28)   eribulin mesylate [CHEBI:70710] (1) ChEBI Compound Accession Identifier:   [CHEBI:70710] ChEBI Compound Description:   A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. ChEBI Compound Identification Number:   70710 ChEBI InChI Value:   "InChI=1S/C40H59NO11.CH4O3S/c1-19-11-24-5-7-28-20(2)12-26(45-28)9-10-40-17-33-36(51-40)37-38(50-33)39(52-40)35-29(49-37)8-6-25(47-35)13-22(42)14-27-31(16-30(46-24)21(19)3)48-32(34(27)44-4)15-23(43)18-41;1-5(2,3)4/h19,23-39,43H,2-3,5-18,41H2,1,4H3;1H3,(H,2,3,4)/t19-,23+,24+,25-,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39+,40+;/m1./s1" ChEBI InChIKey Value:   QAMYWGZHLCQOOJ-WRNBYXCMSA-N ChEBI Compound Name:   eribulin mesylate ChEBI SMILES Value:   CS(O)(=O)=O.[H][C@@]12CC[C@]3([H])O[C@@]([H])(CC[C@@]45C[C@]6([H])O[C@]7([H])[C@@]([H])(O[C@@]8([H])CC[C@]([H])(CC(=O)C[C@]9([H])[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@@]9([H])C[C@@]([H])(O1)C(=C)[C@H](C)C2)O[C@]8([H])[C@]7([H])O4)[C@H]6O5)CC3=C ChEBI Substance ID:   160646022 ChEBI URL:   ChEBI:70710 ChemSpider ID:   26386066 Ontomatica Chemical Accession Key (OnChAKey):   QAMYWGZHLCQOOJ_WRNBYXCMSA_N_000_000000 PubChem Compound ID:   17755248