Item 1 of 1 (back to results) darunavir An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.

Current search: 03. Biological Effects of Specific Chemicals: antimicrobial agent [CHEBI:33281] > antiviral agent [CHEBI:22587] > anti-HIV agent [CHEBI:64946] > HIV protease inhibitor [CHEBI:35660] > darunavir [CHEBI:367163] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  antimicrobial agent [CHEBI:33281] (927)   antiviral agent [CHEBI:22587] (216)   antiviral drug [CHEBI:36044] (50)   darunavir [CHEBI:367163] (1)  anti-HIV agent [CHEBI:64946] (126)   HIV protease inhibitor [CHEBI:35660] (14)   darunavir [CHEBI:367163] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   amide [CHEBI:32988] (1863)   primary amide [CHEBI:33256] (1586)   sulfonamide [CHEBI:35358] (106)   darunavir [CHEBI:367163] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  sulfur molecular entity [CHEBI:26835] (1541)   sulfur oxoacid derivative [CHEBI:33424] (628)   sulfonic acid derivative [CHEBI:33552] (393)   sulfonamide [CHEBI:35358] (106)   darunavir [CHEBI:367163] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carbonyl compound [CHEBI:36586] (5928)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  ester [CHEBI:35701] (3370)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   polycyclic compound [CHEBI:33635] (4078)   heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  bicyclic compound [CHEBI:33636] (1511)   heterobicyclic compound [CHEBI:33672] (1315)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  heterobicyclic compound [CHEBI:33672] (1315)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   oxacycle [CHEBI:38104] (2002)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   furofuran [CHEBI:47790] (6)   darunavir [CHEBI:367163] (1)  organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   carboxylic ester [CHEBI:33308] (1495)   carbamate ester [CHEBI:23003] (103)   darunavir [CHEBI:367163] (1)  heteroatomic molecular entity [CHEBI:37577] (13672)   oxoacid derivative [CHEBI:33241] (3254)   sulfur oxoacid derivative [CHEBI:33424] (628)   sulfonic acid derivative [CHEBI:33552] (393)   sulfonamide [CHEBI:35358] (106)   darunavir [CHEBI:367163] (1) ChEBI Compound Accession Identifier:   [CHEBI:367163] ChEBI Compound Description:   An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors. ChEBI Compound Identification Number:   367163 ChEBI InChI Value:   InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1 ChEBI InChIKey Value:   CJBJHOAVZSMMDJ-HEXNFIEUSA-N ChEBI Compound Name:   darunavir ChEBI SMILES Value:   [H][C@]12OCC[C@@]1([H])[C@H](CO2)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(N)cc1 ChEBI Substance ID:   87351130 ChEBI URL:   ChEBI:367163 ChemSpider ID:   184733 Ontomatica Chemical Accession Key (OnChAKey):   CJBJHOAVZSMMDJ_HEXNFIEUSA_N_000_000000 PubChem Compound ID:   213039