Item 1 of 1 (back to results) fludarabine phosphate A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.

Current search: 03. Biological Effects of Specific Chemicals: antimicrobial agent [CHEBI:33281] > antiviral agent [CHEBI:22587] > fludarabine phosphate [CHEBI:63599] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   enzyme inhibitor [CHEBI:23924] (825)   DNA synthesis inhibitor [CHEBI:59517] (15)   fludarabine phosphate [CHEBI:63599] (1)  antimetabolite [CHEBI:35221] (34)   fludarabine phosphate [CHEBI:63599] (1)  antimicrobial agent [CHEBI:33281] (927)   antiviral agent [CHEBI:22587] (216)   fludarabine phosphate [CHEBI:63599] (1)  immunomodulator [CHEBI:50846] (61)   immunosuppressive agent [CHEBI:35705] (43)   fludarabine phosphate [CHEBI:63599] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antineoplastic agent [CHEBI:35610] (760)   fludarabine phosphate [CHEBI:63599] (1)  prodrug [CHEBI:50266] (88)   fludarabine phosphate [CHEBI:63599] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   fluorine molecular entity [CHEBI:24062] (288)   organofluorine compound [CHEBI:37143] (275)   fludarabine phosphate [CHEBI:63599] (1)  halide [CHEBI:37578] (1402)   organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   fludarabine phosphate [CHEBI:63599] (1)  pnictogen molecular entity [CHEBI:33302] (10027)   phosphorus molecular entity [CHEBI:26082] (2769)   organophosphorus compound [CHEBI:25710] (1528)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  phosphorus oxoacids and derivatives [CHEBI:36360] (2691)   phosphorus oxoacid derivative [CHEBI:36359] (2628)   phosphoric acid derivative [CHEBI:26079] (2611)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  phosphate [CHEBI:26020] (1522)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  phosphoric ester [CHEBI:37734] (1466)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   organooxygen compound [CHEBI:36963] (11352)   glycosyl compound [CHEBI:63161] (1006)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  carbohydrate derivative [CHEBI:63299] (2582)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   glycosyl compound [CHEBI:63161] (1006)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  carbohydrate derivative [CHEBI:63299] (2582)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organophosphorus compound [CHEBI:25710] (1528)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organonitrogen compound [CHEBI:35352] (6705)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   fludarabine phosphate [CHEBI:63599] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   glycosyl compound [CHEBI:63161] (1006)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  carbohydrate derivative [CHEBI:63299] (2582)   N-glycosyl compound [CHEBI:21731] (294)   nucleoside analogue [CHEBI:60783] (14)   fludarabine phosphate [CHEBI:63599] (1)  ester [CHEBI:35701] (3370)   phosphoric ester [CHEBI:37734] (1466)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic aromatic compound [CHEBI:33659] (3593)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   aromatic compound [CHEBI:33655] (3799)   organic aromatic compound [CHEBI:33659] (3593)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic aromatic compound [CHEBI:33659] (3593)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  organic aromatic compound [CHEBI:33659] (3593)   heteroarene [CHEBI:33833] (1648)   nucleobase-containing molecular entity [CHEBI:61120] (573)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  heteroatomic molecular entity [CHEBI:37577] (13672)   oxoacid derivative [CHEBI:33241] (3254)   phosphorus oxoacid derivative [CHEBI:36359] (2628)   phosphoric acid derivative [CHEBI:26079] (2611)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  phosphate [CHEBI:26020] (1522)   organic phosphate [CHEBI:25703] (1511)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  phosphoric ester [CHEBI:37734] (1466)   nucleoside phosphate [CHEBI:25608] (412)   nucleoside monophosphate [CHEBI:17188] (64)   purine nucleoside monophosphate [CHEBI:26392] (39)   purine arabinonucleoside monophosphate [CHEBI:37514] (1)   fludarabine phosphate [CHEBI:63599] (1)  halide [CHEBI:37578] (1402)   organohalogen compound [CHEBI:36684] (976)   organofluorine compound [CHEBI:37143] (275)   fludarabine phosphate [CHEBI:63599] (1) ChEBI Compound Accession Identifier:   [CHEBI:63599] ChEBI Compound Description:   A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. ChEBI Compound Identification Number:   63599 ChEBI InChI Value:   InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1 ChEBI InChIKey Value:   GIUYCYHIANZCFB-FJFJXFQQSA-N ChEBI Compound Name:   fludarabine phosphate ChEBI SMILES Value:   Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O ChEBI Substance ID:   135610126 ChEBI URL:   ChEBI:63599 ChemSpider ID:   NS Ontomatica Chemical Accession Key (OnChAKey):   GIUYCYHIANZCFB_FJFJXFQQSA_N_000_000000 PubChem Compound ID:   30751