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butorphanol
Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain.


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03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > opioid agent [CHEBI:60598] > kappa-opioid agent [CHEBI:60603]
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03. Biological Effects of Specific Chemicals 
03. Biological Effects of Specific Chemicals
 pharmacological uses [CHEBI:52210] (736) 
 analgesic [CHEBI:35480] (114) 
 opioid analgesic [CHEBI:35482] (40) 
 butorphanol [CHEBI:3242] (1)
 neurotransmitter agent [CHEBI:35942] (471) 
 opioid agent [CHEBI:60598] (32) 
 mu-opioid agent [CHEBI:60599] (26) 
 mu-opioid receptor agonist [CHEBI:55322] (22) 
 butorphanol [CHEBI:3242] (1)
 kappa-opioid agent [CHEBI:60603] (6) 
 kappa-opioid receptor agonist [CHEBI:59282] (6) 
 butorphanol [CHEBI:3242] (1)
05. Industrial Uses 
05. Industrial Uses
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 antitussive [CHEBI:51177] (13) 
 butorphanol [CHEBI:3242] (1)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 p-block molecular entity [CHEBI:33675] (25343) 
 pnictogen molecular entity [CHEBI:33302] (10027) 
 nitrogen molecular entity [CHEBI:51143] (7930) 
 organonitrogen compound [CHEBI:35352] (6705) 
 alkaloid [CHEBI:22315] (473) 
 isoquinoline alkaloid [CHEBI:24921] (120) 
 morphinane alkaloid [CHEBI:25418] (22) 
 butorphanol [CHEBI:3242] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organonitrogen compound [CHEBI:35352] (6705) 
 alkaloid [CHEBI:22315] (473) 
 isoquinoline alkaloid [CHEBI:24921] (120) 
 morphinane alkaloid [CHEBI:25418] (22) 
 butorphanol [CHEBI:3242] (1)
ChEBI Compound Accession Identifier  [CHEBI:3242]
ChEBI Compound Description  Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain.
ChEBI Compound Identification Number  3242
ChEBI InChI Value  InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1
ChEBI InChIKey Value  IFKLAQQSCNILHL-QHAWAJNXSA-N
ChEBI Compound Name  butorphanol
ChEBI SMILES Value  Oc1ccc2C[C@H]3N(CC[C@@]4(CCCC[C@@]34O)c2c1)CC1CCC1
ChEBI Substance ID  92729940
ChEBI URL  ChEBI:3242
ChemSpider ID  16735714
Ontomatica Chemical Accession Key (OnChAKey)  IFKLAQQSCNILHL_QHAWAJNXSA_N_000_000000
PubChem Compound ID  5361092