Item 15 of 21 (back to results) previous next CGP 78608 hydrochloride A hydrochloride that is the monohydrochloride salt of CGP 78608. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > antagonist [CHEBI:48706] > excitatory amino acid antagonist [CHEBI:60798] > NMDA receptor antagonist [CHEBI:60797] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   antagonist [CHEBI:48706] (126)   excitatory amino acid antagonist [CHEBI:60798] (23)   NMDA receptor antagonist [CHEBI:60797] (21)   CGP 78608 hydrochloride [CHEBI:64065] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   central nervous system drug [CHEBI:35470] (217)   central nervous system depressant [CHEBI:35488] (90)   anticonvulsant [CHEBI:35623] (39)   CGP 78608 hydrochloride [CHEBI:64065] (1)  prodrug [CHEBI:50266] (88)   CGP 78608 hydrochloride [CHEBI:64065] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   chlorine molecular entity [CHEBI:23117] (884)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   CGP 78608 hydrochloride [CHEBI:64065] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   CGP 78608 hydrochloride [CHEBI:64065] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic halide salt [CHEBI:51069] (386)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   CGP 78608 hydrochloride [CHEBI:64065] (1)  halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   CGP 78608 hydrochloride [CHEBI:64065] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   CGP 78608 hydrochloride [CHEBI:64065] (1) ChEBI Compound Accession Identifier:   [CHEBI:64065] ChEBI Compound Description:   A hydrochloride that is the monohydrochloride salt of CGP 78608. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration. ChEBI Compound Identification Number:   64065 ChEBI InChI Value:   "InChI=1S/C11H13BrN3O5P.ClH/c1-5(21(18,19)20)13-4-6-2-7(12)3-8-9(6)15-11(17)10(16)14-8;/h2-3,5,13H,4H2,1H3,(H,14,16)(H,15,17)(H2,18,19,20);1H/t5-;/m0./s1" ChEBI InChIKey Value:   MZQQZBPMRPDKTB-JEDNCBNOSA-N ChEBI Compound Name:   CGP 78608 hydrochloride ChEBI SMILES Value:   Cl.C[C@@H](NCc1cc(Br)cc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O ChEBI Substance ID:   135610876 ChEBI URL:   ChEBI:64065 ChemSpider ID:   NS Ontomatica Chemical Accession Key (OnChAKey):   MZQQZBPMRPDKTB_JEDNCBNOSA_N_000_000000 PubChem Compound ID:   24978530