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desloratadine
Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.


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03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > neurotransmitter agent [CHEBI:35942] > histaminergic drug [CHEBI:37957] > histamine antagonist [CHEBI:37956] > H1-receptor antagonist [CHEBI:37955]
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03. Biological Effects of Specific Chemicals 
03. Biological Effects of Specific Chemicals
 pharmacological uses [CHEBI:52210] (736) 
 neurotransmitter agent [CHEBI:35942] (471) 
 histaminergic drug [CHEBI:37957] (94) 
 histamine antagonist [CHEBI:37956] (87) 
 H1-receptor antagonist [CHEBI:37955] (57) 
 desloratadine [CHEBI:291342] (1)
 cholinergic drug [CHEBI:38323] (108) 
 cholinergic antagonist [CHEBI:48873] (84) 
 desloratadine [CHEBI:291342] (1)
05. Industrial Uses 
05. Industrial Uses
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 anti-allergic agent [CHEBI:50857] (51) 
 desloratadine [CHEBI:291342] (1)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 p-block molecular entity [CHEBI:33675] (25343) 
 pnictogen molecular entity [CHEBI:33302] (10027) 
 nitrogen molecular entity [CHEBI:51143] (7930) 
 organonitrogen compound [CHEBI:35352] (6705) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organonitrogen compound [CHEBI:35352] (6705) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic molecule [CHEBI:72695] (11399) 
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic polycyclic compound [CHEBI:51958] (1654) 
 organic tricyclic compound [CHEBI:51959] (755) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 polyatomic entity [CHEBI:36357] (18777) 
 molecule [CHEBI:25367] (11520) 
 cyclic compound [CHEBI:33595] (7817) 
 polycyclic compound [CHEBI:33635] (4078) 
 heteropolycyclic compound [CHEBI:33671] (2613) 
 heterotricyclic compound [CHEBI:36688] (541) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic polycyclic compound [CHEBI:51958] (1654) 
 organic tricyclic compound [CHEBI:51959] (755) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic polycyclic compound [CHEBI:51958] (1654) 
 organic tricyclic compound [CHEBI:51959] (755) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 heterocyclic compound [CHEBI:5686] (5275) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 heteropolycyclic compound [CHEBI:33671] (2613) 
 heterotricyclic compound [CHEBI:36688] (541) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic molecule [CHEBI:72695] (11399) 
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organonitrogen heterocyclic compound [CHEBI:38101] (3202) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
 organic polycyclic compound [CHEBI:51958] (1654) 
 organic tricyclic compound [CHEBI:51959] (755) 
 organic heterotricyclic compound [CHEBI:26979] (541) 
 benzocycloheptapyridine [CHEBI:48593] (3) 
 desloratadine [CHEBI:291342] (1)
ChEBI Compound Accession Identifier  [CHEBI:291342]
ChEBI Compound Description  Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
ChEBI Compound Identification Number  291342
ChEBI InChI Value  InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
ChEBI InChIKey Value  JAUOIFJMECXRGI-UHFFFAOYSA-N
ChEBI Compound Name  desloratadine
ChEBI SMILES Value  Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1
ChEBI Substance ID  85483828
ChEBI URL  ChEBI:291342
ChemSpider ID  110575
Ontomatica Chemical Accession Key (OnChAKey)  JAUOIFJMECXRGI_UHFFFAOYSA_N_000_000000
PubChem Compound ID  124087