Item 1 of 1 (back to results) 2-methyl-6-(phenylethynyl)pyridine hydrochloride A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Current search: 05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > central nervous system drug [CHEBI:35470] > psychotropic drug [CHEBI:35471] > tranquilizing drug [CHEBI:35473] > anxiolytic drug [CHEBI:35474] > 2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   antagonist [CHEBI:48706] (126)   metabotropic glutamate receptor antagonist [CHEBI:63963] (3)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   central nervous system drug [CHEBI:35470] (217)   psychotropic drug [CHEBI:35471] (130)   tranquilizing drug [CHEBI:35473] (83)   anxiolytic drug [CHEBI:35474] (31)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   chlorine molecular entity [CHEBI:23117] (884)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic halide salt [CHEBI:51069] (386)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1)  halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   chloride salt [CHEBI:23114] (326)   organic chloride salt [CHEBI:36094] (294)   hydrochloride [CHEBI:36807] (240)   2-methyl-6-(phenylethynyl)pyridine hydrochloride [CHEBI:64158] (1) ChEBI Compound Accession Identifier:   [CHEBI:64158] ChEBI Compound Description:   A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. ChEBI Compound Identification Number:   64158 ChEBI InChI Value:   "InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H" ChEBI InChIKey Value:   PKDHDJBNEKXCBI-UHFFFAOYSA-N ChEBI Compound Name:   2-methyl-6-(phenylethynyl)pyridine hydrochloride ChEBI SMILES Value:   Cl.Cc1cccc(n1)C#Cc1ccccc1 ChEBI Substance ID:   135610597 ChEBI URL:   ChEBI:64158 ChemSpider ID:   NS Ontomatica Chemical Accession Key (OnChAKey):   PKDHDJBNEKXCBI_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   9794588