Item 1 of 1 (back to results) N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide A hydrobromide salt prepared from N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, alpha1A and alpha1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

Current search: 05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > prodrug [CHEBI:50266] > N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   dopaminergic agent [CHEBI:48560] (99)   dopamine agonist [CHEBI:51065] (26)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   prodrug [CHEBI:50266] (88)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   halogen molecular entity [CHEBI:24471] (1475)   bromine molecular entity [CHEBI:22928] (199)   bromide salt [CHEBI:22925] (45)   organic bromide salt [CHEBI:48369] (33)   hydrobromide [CHEBI:48367] (13)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   bromide salt [CHEBI:22925] (45)   organic bromide salt [CHEBI:48369] (33)   hydrobromide [CHEBI:48367] (13)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1)  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   organic halide salt [CHEBI:51069] (386)   organic bromide salt [CHEBI:48369] (33)   hydrobromide [CHEBI:48367] (13)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1)  halide salt [CHEBI:33958] (423)   bromide salt [CHEBI:22925] (45)   organic bromide salt [CHEBI:48369] (33)   hydrobromide [CHEBI:48367] (13)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1)  halide [CHEBI:37578] (1402)   halide salt [CHEBI:33958] (423)   bromide salt [CHEBI:22925] (45)   organic bromide salt [CHEBI:48369] (33)   hydrobromide [CHEBI:48367] (13)   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide [CHEBI:64002] (1) ChEBI Compound Accession Identifier:   [CHEBI:64002] ChEBI Compound Description:   A hydrobromide salt prepared from N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, alpha1A and alpha1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys. ChEBI Compound Identification Number:   64002 ChEBI InChI Value:   "InChI=1S/C20H22ClNO2.BrH/c1-3-8-22-9-7-15-16(11-18(23)20(24)19(15)21)17(12-22)14-6-4-5-13(2)10-14;/h3-6,10-11,17,23-24H,1,7-9,12H2,2H3;1H" ChEBI InChIKey Value:   CFWPKYBBXBANLU-UHFFFAOYSA-N ChEBI Compound Name:   N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide ChEBI SMILES Value:   Br.Cc1cccc(c1)C1CN(CCc2c1cc(O)c(O)c2Cl)CC=C ChEBI Substance ID:   135610668 ChEBI URL:   ChEBI:64002 ChemSpider ID:   24605935 Ontomatica Chemical Accession Key (OnChAKey):   CFWPKYBBXBANLU_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   12909789