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clodronic acid
Methylene chloride in which both hydrogens are substituted by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.


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05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > antineoplastic agent [CHEBI:35610] > clodronic acid [CHEBI:110423]
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05. Industrial Uses 
05. Industrial Uses
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 antineoplastic agent [CHEBI:35610] (760) 
 clodronic acid [CHEBI:110423] (1)
 bone density conservation agent [CHEBI:50646] (18) 
 clodronic acid [CHEBI:110423] (1)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 p-block molecular entity [CHEBI:33675] (25343) 
 halogen molecular entity [CHEBI:24471] (1475) 
 chlorine molecular entity [CHEBI:23117] (884) 
 organochlorine compound [CHEBI:36683] (543) 
 clodronic acid [CHEBI:110423] (1)
 halide [CHEBI:37578] (1402) 
 organohalogen compound [CHEBI:36684] (976) 
 organochlorine compound [CHEBI:36683] (543) 
 clodronic acid [CHEBI:110423] (1)
 pnictogen molecular entity [CHEBI:33302] (10027) 
 phosphorus molecular entity [CHEBI:26082] (2769) 
 phosphorus oxoacids and derivatives [CHEBI:36360] (2691) 
 phosphonic acids [CHEBI:26069] (25) 
 clodronic acid [CHEBI:110423] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organohalogen compound [CHEBI:36684] (976) 
 organochlorine compound [CHEBI:36683] (543) 
 clodronic acid [CHEBI:110423] (1)
 one-carbon compound [CHEBI:64708] (104) 
 clodronic acid [CHEBI:110423] (1)
 polyatomic entity [CHEBI:36357] (18777) 
 heteroatomic molecular entity [CHEBI:37577] (13672) 
 halide [CHEBI:37578] (1402) 
 organohalogen compound [CHEBI:36684] (976) 
 organochlorine compound [CHEBI:36683] (543) 
 clodronic acid [CHEBI:110423] (1)
ChEBI Compound Accession Identifier  [CHEBI:110423]
ChEBI Compound Description  Methylene chloride in which both hydrogens are substituted by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
ChEBI Compound Identification Number  110423
ChEBI InChI Value  InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
ChEBI InChIKey Value  ACSIXWWBWUQEHA-UHFFFAOYSA-N
ChEBI Compound Name  clodronic acid
ChEBI SMILES Value  OP(O)(=O)C(Cl)(Cl)P(O)(O)=O
ChEBI Substance ID  85315811
ChEBI URL  ChEBI:110423
ChemSpider ID  23731
Ontomatica Chemical Accession Key (OnChAKey)  ACSIXWWBWUQEHA_UHFFFAOYSA_N_000_000000
PubChem Compound ID  25419