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7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine
A indolocarbazole alkaloid that is 4'-N-demethyl staurosporine substituted by hydroxy groups at positions 8 and 9 and an xo group at position 7. Isolated from Cystodytes solitus, it exhibits antineoplastic activity.

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05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > antineoplastic agent [CHEBI:35610] > 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840]
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more general categories    information about this item
03. Biological Effects of Specific Chemicals 
03. Biological Effects of Specific Chemicals
 biochemical uses [CHEBI:52206] (3306) 
 metabolite [CHEBI:25212] (2692) 
 secondary metabolite [CHEBI:26619] (2225) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
05. Industrial Uses 
05. Industrial Uses
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 antineoplastic agent [CHEBI:35610] (760) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 s-block molecular entity [CHEBI:33674] (7287) 
 hydrogen molecular entity [CHEBI:33608] (6932) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 p-block molecular entity [CHEBI:33675] (25343) 
 pnictogen molecular entity [CHEBI:33302] (10027) 
 nitrogen molecular entity [CHEBI:51143] (7930) 
 organonitrogen compound [CHEBI:35352] (6705) 
 alkaloid [CHEBI:22315] (473) 
 indole alkaloid [CHEBI:38958] (144) 
 indolocarbazole alkaloid [CHEBI:37697] (4) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 chalcogen molecular entity [CHEBI:33304] (15225) 
 oxygen molecular entity [CHEBI:25806] (14414) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organonitrogen compound [CHEBI:35352] (6705) 
 alkaloid [CHEBI:22315] (473) 
 indole alkaloid [CHEBI:38958] (144) 
 indolocarbazole alkaloid [CHEBI:37697] (4) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic hydroxy compound [CHEBI:33822] (3050) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic molecule [CHEBI:72695] (11399) 
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic aromatic compound [CHEBI:33659] (3593) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 polyatomic entity [CHEBI:36357] (18777) 
 molecule [CHEBI:25367] (11520) 
 cyclic compound [CHEBI:33595] (7817) 
 polycyclic compound [CHEBI:33635] (4078) 
 heteropolycyclic compound [CHEBI:33671] (2613) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 aromatic compound [CHEBI:33655] (3799) 
 organic aromatic compound [CHEBI:33659] (3593) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic aromatic compound [CHEBI:33659] (3593) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 heterocyclic compound [CHEBI:5686] (5275) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 heteropolycyclic compound [CHEBI:33671] (2613) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic molecule [CHEBI:72695] (11399) 
 organic cyclic compound [CHEBI:33832] (7633) 
 organic heterocyclic compound [CHEBI:24532] (5243) 
 organic heteropolycyclic compound [CHEBI:38166] (2613) 
 organic heterooctacyclic compound [CHEBI:38165] (5) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 indolocarbazole [CHEBI:51915] (9) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 organic aromatic compound [CHEBI:33659] (3593) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
 heteroatomic molecular entity [CHEBI:37577] (13672) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 phenols [CHEBI:33853] (868) 
 7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine [CHEBI:66840] (1)
ChEBI Compound Accession Identifier:   [CHEBI:66840]
ChEBI Compound Description:   A indolocarbazole alkaloid that is 4'-N-demethyl staurosporine substituted by hydroxy groups at positions 8 and 9 and an xo group at position 7. Isolated from Cystodytes solitus, it exhibits antineoplastic activity.
ChEBI Compound Identification Number:   66840
ChEBI InChI Value:   InChI=1S/C27H22N4O6/c1-27-24(36-2)11(28)9-15(37-27)30-12-6-4-3-5-10(12)16-19-20(26(35)29-25(19)34)18-17-13(7-8-14(32)23(17)33)31(27)22(18)21(16)30/h3-8,11,15,24,32-33H,9,28H2,1-2H3,(H,29,34,35)/t11-,15-,24-,27+/m1/s1
ChEBI InChIKey Value:   MPFXTYXHOXVKPU-YWVZRHFBSA-N
ChEBI Compound Name:   7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine
ChEBI SMILES Value:   [H][C@]12C[C@@H](N)[C@@H](OC)[C@](C)(O1)n1c3ccc(O)c(O)c3c3c4C(=O)NC(=O)c4c4c5ccccc5n2c4c13
ChEBI Substance ID:   160710349
ChEBI URL:   ChEBI:66840
ChemSpider ID:   24705710
Ontomatica Chemical Accession Key (OnChAKey):   MPFXTYXHOXVKPU_YWVZRHFBSA_N_000_000000
PubChem Compound ID:   24899411