Item 1 of 1 (back to results) temozolomide An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

Current search: 05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > antineoplastic agent [CHEBI:35610] > temozolomide [CHEBI:72564] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  aetiopathogenetic uses [CHEBI:52209] (178)   genotoxin [CHEBI:50902] (78)   mutagen [CHEBI:25435] (74)   alkylating agent [CHEBI:22333] (29)   temozolomide [CHEBI:72564] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antineoplastic agent [CHEBI:35610] (760)   temozolomide [CHEBI:72564] (1)  prodrug [CHEBI:50266] (88)   temozolomide [CHEBI:72564] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   amide [CHEBI:32988] (1863)   primary amide [CHEBI:33256] (1586)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  triazene derivative [CHEBI:72573] (3)   temozolomide [CHEBI:72564] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carboxamide [CHEBI:37622] (1381)   monocarboxylic acid amide [CHEBI:29347] (257)   temozolomide [CHEBI:72564] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   polycyclic compound [CHEBI:33635] (4078)   heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  bicyclic compound [CHEBI:33636] (1511)   heterobicyclic compound [CHEBI:33672] (1315)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  heterobicyclic compound [CHEBI:33672] (1315)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterobicyclic compound [CHEBI:27171] (1315)   imidazotetrazine [CHEBI:72565] (1)   temozolomide [CHEBI:72564] (1) ChEBI Compound Accession Identifier:   [CHEBI:72564] ChEBI Compound Description:   An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma. ChEBI Compound Identification Number:   72564 ChEBI InChI Value:   InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) ChEBI InChIKey Value:   BPEGJWRSRHCHSN-UHFFFAOYSA-N ChEBI Compound Name:   temozolomide ChEBI SMILES Value:   Cn1nnc2c(ncn2c1=O)C(N)=O ChEBI Substance ID:   160962826 ChEBI URL:   ChEBI:72564 ChemSpider ID:   5201 Ontomatica Chemical Accession Key (OnChAKey):   BPEGJWRSRHCHSN_UHFFFAOYSA_N_000_000000 PubChem Compound ID:   5394