Item 47 of 51 (back to results) previous next methiothepin maleate A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Current search: 05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > central nervous system drug [CHEBI:35470] > psychotropic drug [CHEBI:35471] > tranquilizing drug [CHEBI:35473] > antipsychotic agent [CHEBI:35476] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   serotonergic drug [CHEBI:48278] (109)   serotonergic antagonist [CHEBI:48279] (52)   methiothepin maleate [CHEBI:64202] (1)  dopaminergic agent [CHEBI:48560] (99)   dopaminergic antagonist [CHEBI:48561] (48)   methiothepin maleate [CHEBI:64202] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   central nervous system drug [CHEBI:35470] (217)   psychotropic drug [CHEBI:35471] (130)   tranquilizing drug [CHEBI:35473] (83)   antipsychotic agent [CHEBI:35476] (51)   methiothepin maleate [CHEBI:64202] (1) 08. Chemical Category  08. Chemical Category  polyatomic entity [CHEBI:36357] (18777)   heteroatomic molecular entity [CHEBI:37577] (13672)   salt [CHEBI:24866] (931)   organic salt [CHEBI:24868] (775)   maleate salt [CHEBI:50221] (31)   methiothepin maleate [CHEBI:64202] (1) ChEBI Compound Accession Identifier:   [CHEBI:64202] ChEBI Compound Description:   A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). ChEBI Compound Identification Number:   64202 ChEBI InChI Value:   "InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-" ChEBI InChIKey Value:   IWDBEHWZGDSFHR-BTJKTKAUSA-N ChEBI Compound Name:   methiothepin maleate ChEBI SMILES Value:   OC(=O)\\C=C/C(O)=O.CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 ChEBI Substance ID:   135610758 ChEBI URL:   ChEBI:64202 ChemSpider ID:   4513895 Ontomatica Chemical Accession Key (OnChAKey):   IWDBEHWZGDSFHR_BTJKTKAUSA_N_000_000000 PubChem Compound ID:   5358812