Item 1 of 1 (back to results) glionitrin A A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring. It is an antibiotic isolated from the microbial strains Sphingomonas and Aspergillus fumigatus, and exhibits cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145.

Current search: 07. Part of Biological Source of Chemical: unspecified structure [PO:0000004] × 03. Biological Effects of Specific Chemicals: antimicrobial agent [CHEBI:33281] > antibiotic [CHEBI:22582] > glionitrin A [CHEBI:65967] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   metabolite [CHEBI:25212] (2692)   secondary metabolite [CHEBI:26619] (2225)   glionitrin A [CHEBI:65967] (1)  antimicrobial agent [CHEBI:33281] (927)   antibiotic [CHEBI:22582] (193)   glionitrin A [CHEBI:65967] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antineoplastic agent [CHEBI:35610] (760)   glionitrin A [CHEBI:65967] (1) 06. Name of Biological Source of Chemical  06. Name of Biological Source of Chemical  Archaea, Cyanobacteria and Bacteria (302)   Eubacteria (239)   Proteobacteria (23)   alpha-Proteobacteria (3)   Sphingomonadales (2)   Sphingomonadaceae (2)   Sphingomonas (2)  Fungi, Yeasts, Molds and Mildews (348)   Deuteromycotina (255)   Hyphomycetes (137)   Aspergillus (96)   Aspergillus fumigatus (12) 07. Part of Biological Source of Chemical  07. Part of Biological Source of Chemical  unspecified structure [PO:0000004] (703) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  nitro compound [CHEBI:35715] (192)   C-nitro compound [CHEBI:35716] (171)   glionitrin A [CHEBI:65967] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   sulfur molecular entity [CHEBI:26835] (1541)   organosulfur compound [CHEBI:33261] (1005)   organic disulfide [CHEBI:35489] (36)   glionitrin A [CHEBI:65967] (1)  disulfide [CHEBI:48343] (41)   organic disulfide [CHEBI:35489] (36)   glionitrin A [CHEBI:65967] (1)  organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   organic disulfide [CHEBI:35489] (36)   glionitrin A [CHEBI:65967] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  organonitrogen compound [CHEBI:35352] (6705)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organochalcogen compound [CHEBI:36962] (11874)   organosulfur compound [CHEBI:33261] (1005)   organic disulfide [CHEBI:35489] (36)   glionitrin A [CHEBI:65967] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   polycyclic compound [CHEBI:33635] (4078)   heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   pyrazinoindole [CHEBI:64130] (2)   glionitrin A [CHEBI:65967] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   organic heterotetracyclic compound [CHEBI:38163] (128)   glionitrin A [CHEBI:65967] (1) ChEBI Compound Accession Identifier:   [CHEBI:65967] ChEBI Compound Description:   A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring. It is an antibiotic isolated from the microbial strains Sphingomonas and Aspergillus fumigatus, and exhibits cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145. ChEBI Compound Identification Number:   65967 ChEBI InChI Value:   InChI=1S/C13H11N3O5S2/c1-14-10(18)12-5-7-2-3-8(16(20)21)4-9(7)15(12)11(19)13(14,6-17)23-22-12/h2-4,17H,5-6H2,1H3/t12-,13-/m0/s1 ChEBI InChIKey Value:   VRFJINVAZRAFHH-STQMWFEESA-N ChEBI Compound Name:   glionitrin A ChEBI SMILES Value:   CN1C(=O)[C@@]23Cc4ccc(cc4N2C(=O)[C@]1(CO)SS3)[N+]([O-])=O ChEBI Substance ID:   160710074 ChEBI URL:   ChEBI:65967 ChemSpider ID:   NS Ontomatica Chemical Accession Key (OnChAKey):   VRFJINVAZRAFHH_STQMWFEESA_N_000_000000 PubChem Compound ID:   25243252