Item 1 of 2 (back to results) next bicuculline Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.

Current search: 03. Biological Effects of Specific Chemicals: aetiopathogenetic uses [CHEBI:52209] × 05. Industrial Uses: pharmaceutical [CHEBI:52217] > drug [CHEBI:23888] > central nervous system drug [CHEBI:35470] > central nervous system stimulant [CHEBI:35337] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biophysical uses [CHEBI:52208] (136)   membrane transport modulator [CHEBI:38632] (122)   GABA-gated chloride channel antagonist [CHEBI:38999] (6)   bicuculline [CHEBI:3092] (1)  aetiopathogenetic uses [CHEBI:52209] (178)   neurotoxin [CHEBI:50910] (26)   bicuculline [CHEBI:3092] (1)  pharmacological uses [CHEBI:52210] (736)   neurotransmitter agent [CHEBI:35942] (471)   GABA agent [CHEBI:51374] (7)   GABA antagonist [CHEBI:65259] (3)   bicuculline [CHEBI:3092] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   central nervous system drug [CHEBI:35470] (217)   central nervous system stimulant [CHEBI:35337] (15)   bicuculline [CHEBI:3092] (1)  agrochemical [CHEBI:33286] (142)   bicuculline [CHEBI:3092] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   alkaloid [CHEBI:22315] (473)   isoquinoline alkaloid [CHEBI:24921] (120)   bicuculline [CHEBI:3092] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organonitrogen compound [CHEBI:35352] (6705)   alkaloid [CHEBI:22315] (473)   isoquinoline alkaloid [CHEBI:24921] (120)   bicuculline [CHEBI:3092] (1)  organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   cyclic compound [CHEBI:33595] (7817)   polycyclic compound [CHEBI:33635] (4078)   heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  heterocyclic compound [CHEBI:5686] (5275)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  heteropolycyclic compound [CHEBI:33671] (2613)   organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic molecule [CHEBI:72695] (11399)   organic cyclic compound [CHEBI:33832] (7633)   organic heterocyclic compound [CHEBI:24532] (5243)   organonitrogen heterocyclic compound [CHEBI:38101] (3202)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1)  organic heteropolycyclic compound [CHEBI:38166] (2613)   isoquinolines [CHEBI:24922] (86)   bicuculline [CHEBI:3092] (1) ChEBI Compound Accession Identifier:   [CHEBI:3092] ChEBI Compound Description:   Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. ChEBI Compound Identification Number:   3092 ChEBI InChI Value:   InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 ChEBI InChIKey Value:   IYGYMKDQCDOMRE-ZWKOTPCHSA-N ChEBI Compound Name:   bicuculline ChEBI SMILES Value:   [H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12 ChEBI Substance ID:   85305365 ChEBI URL:   ChEBI:3092 ChemSpider ID:   9820 Ontomatica Chemical Accession Key (OnChAKey):   IYGYMKDQCDOMRE_ZWKOTPCHSA_N_000_000000 PubChem Compound ID:   10237