Item 2 of 8 (back to results) previous next (-)-demecolcine A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.

Current search: 03. Biological Effects of Specific Chemicals: pharmacological uses [CHEBI:52210] > tubulin modulator [CHEBI:60832] × 05. Industrial Uses: pharmaceutical [CHEBI:52217] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  pharmacological uses [CHEBI:52210] (736)   tubulin modulator [CHEBI:60832] (12)   microtubule-destabilising agent [CHEBI:61951] (9)   (-)-demecolcine [CHEBI:4393] (1) 05. Industrial Uses  05. Industrial Uses  pharmaceutical [CHEBI:52217] (1978)   drug [CHEBI:23888] (1930)   antineoplastic agent [CHEBI:35610] (760)   (-)-demecolcine [CHEBI:4393] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   organonitrogen compound [CHEBI:35352] (6705)   alkaloid [CHEBI:22315] (473)   (-)-demecolcine [CHEBI:4393] (1)  organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   (-)-demecolcine [CHEBI:4393] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organonitrogen compound [CHEBI:35352] (6705)   alkaloid [CHEBI:22315] (473)   (-)-demecolcine [CHEBI:4393] (1)  organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   (-)-demecolcine [CHEBI:4393] (1)  organic amino compound [CHEBI:50047] (2472)   secondary amino compound [CHEBI:50995] (110)   (-)-demecolcine [CHEBI:4393] (1) ChEBI Compound Accession Identifier:   [CHEBI:4393] ChEBI Compound Description:   A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. ChEBI Compound Identification Number:   4393 ChEBI InChI Value:   InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1 ChEBI InChIKey Value:   NNJPGOLRFBJNIW-HNNXBMFYSA-N ChEBI Compound Name:   (-)-demecolcine ChEBI SMILES Value:   CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(OC)c(=O)cc12 ChEBI Substance ID:   135610167 ChEBI URL:   ChEBI:4393 ChemSpider ID:   191135 Ontomatica Chemical Accession Key (OnChAKey):   NNJPGOLRFBJNIW_HNNXBMFYSA_N_000_000000 PubChem Compound ID:   220401