Item 208 of 10027 (back to results) previous next candoxatrilat The amide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1H-inden-5-yl ester prodrug in the treatment of chronic heart failure.

Current search: 08. Chemical Category: main group molecular entity [CHEBI:33579] > p-block molecular entity [CHEBI:33675] > pnictogen molecular entity [CHEBI:33302] × Select any link to see items in a related category. more general categories    information about this item 03. Biological Effects of Specific Chemicals  03. Biological Effects of Specific Chemicals  biochemical uses [CHEBI:52206] (3306)   enzyme inhibitor [CHEBI:23924] (825)   protease inhibitor [CHEBI:37670] (37)   metalloendopeptidase inhibitor [CHEBI:59107] (3)   candoxatrilat [CHEBI:3354] (1) 08. Chemical Category  08. Chemical Category  main group molecular entity [CHEBI:33579] (25650)   s-block molecular entity [CHEBI:33674] (7287)   hydrogen molecular entity [CHEBI:33608] (6932)   hydroxides [CHEBI:24651] (5641)   oxoacid [CHEBI:24833] (3119)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  p-block molecular entity [CHEBI:33675] (25343)   pnictogen molecular entity [CHEBI:33302] (10027)   nitrogen molecular entity [CHEBI:51143] (7930)   amide [CHEBI:32988] (1863)   primary amide [CHEBI:33256] (1586)   carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  chalcogen molecular entity [CHEBI:33304] (15225)   oxygen molecular entity [CHEBI:25806] (14414)   hydroxides [CHEBI:24651] (5641)   oxoacid [CHEBI:24833] (3119)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  organooxygen compound [CHEBI:36963] (11352)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carbonyl compound [CHEBI:36586] (5928)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carbonyl compound [CHEBI:36586] (5928)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  carbon group molecular entity [CHEBI:33582] (23847)   organic molecular entity [CHEBI:50860] (23769)   heteroorganic entity [CHEBI:33285] (15197)   organonitrogen compound [CHEBI:35352] (6705)   carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  organochalcogen compound [CHEBI:36962] (11874)   organooxygen compound [CHEBI:36963] (11352)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carbonyl compound [CHEBI:36586] (5928)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  carboxamide [CHEBI:37622] (1381)   candoxatrilat [CHEBI:3354] (1)  organic acid [CHEBI:64709] (3008)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  organic molecule [CHEBI:72695] (11399)   organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  polyatomic entity [CHEBI:36357] (18777)   molecule [CHEBI:25367] (11520)   organic molecule [CHEBI:72695] (11399)   organic oxo compound [CHEBI:36587] (5932)   carbonyl compound [CHEBI:36586] (5928)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1)  heteroatomic molecular entity [CHEBI:37577] (13672)   hydroxides [CHEBI:24651] (5641)   oxoacid [CHEBI:24833] (3119)   carbon oxoacid [CHEBI:35605] (3012)   carboxylic acid [CHEBI:33575] (3005)   dicarboxylic acid [CHEBI:35692] (312)   candoxatrilat [CHEBI:3354] (1) ChEBI Compound Accession Identifier:   [CHEBI:3354] ChEBI Compound Description:   The amide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1H-inden-5-yl ester prodrug in the treatment of chronic heart failure. ChEBI Compound Identification Number:   3354 ChEBI InChI Value:   InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-,16+/m0/s1 ChEBI InChIKey Value:   ACZWIDANLCXHBM-HRCADAONSA-N ChEBI Compound Name:   candoxatrilat ChEBI SMILES Value:   COCCOC[C@H](CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(O)=O ChEBI Substance ID:   92729943 ChEBI URL:   ChEBI:3354 ChemSpider ID:   16736848 Ontomatica Chemical Accession Key (OnChAKey):   ACZWIDANLCXHBM_HRCADAONSA_N_000_000000 PubChem Compound ID:   443380