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TMC-1A
A polyene antibiotic that is hexa-1,3,5-triene substituted at position 1 by a cyclohex-1-en-1-yl group which is substituted by a (2,4-dimethyloct-2-enoyl)amino group, hydroxy groups and oxo group at positions 1, 3, 4 and 6 respectively and at position 6 by a N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)formamyl group. It is an antitumour antibiotic isolated from Streptomyces sp. A-230.

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07. Part of Biological Source of Chemical: unspecified structure [PO:0000004]
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05. Industrial Uses: pharmaceutical [CHEBI:52217]
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more general categories    information about this item
03. Biological Effects of Specific Chemicals 
03. Biological Effects of Specific Chemicals
 biochemical uses [CHEBI:52206] (3306) 
 metabolite [CHEBI:25212] (2692) 
 secondary metabolite [CHEBI:26619] (2225) 
 TMC-1A [CHEBI:66234] (1)
05. Industrial Uses 
05. Industrial Uses
 pharmaceutical [CHEBI:52217] (1978) 
 drug [CHEBI:23888] (1930) 
 antineoplastic agent [CHEBI:35610] (760) 
 TMC-1A [CHEBI:66234] (1)
06. Name of Biological Source of Chemical 
06. Name of Biological Source of Chemical
 Archaea, Cyanobacteria and Bacteria (302) 
 Eubacteria (239) 
 Firmicutes (214) 
 Actinobacteria (204) 
 Actinobacteridae (204) 
 Actinomycetales (204) 
 Streptomycetaceae (160) 
 Streptomyces (157)
07. Part of Biological Source of Chemical 
07. Part of Biological Source of Chemical
 unspecified structure [PO:0000004] (703)
08. Chemical Category 
08. Chemical Category
 main group molecular entity [CHEBI:33579] (25650) 
 s-block molecular entity [CHEBI:33674] (7287) 
 hydrogen molecular entity [CHEBI:33608] (6932) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 polyene antibiotic [CHEBI:26177] (10) 
 TMC-1A [CHEBI:66234] (1)
 alcohol [CHEBI:30879] (1371) 
 tertiary alcohol [CHEBI:26878] (183) 
 TMC-1A [CHEBI:66234] (1)
 secondary alcohol [CHEBI:35681] (342) 
 TMC-1A [CHEBI:66234] (1)
 enol [CHEBI:33823] (52) 
 TMC-1A [CHEBI:66234] (1)
 p-block molecular entity [CHEBI:33675] (25343) 
 pnictogen molecular entity [CHEBI:33302] (10027) 
 nitrogen molecular entity [CHEBI:51143] (7930) 
 amide [CHEBI:32988] (1863) 
 primary amide [CHEBI:33256] (1586) 
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 organonitrogen compound [CHEBI:35352] (6705) 
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 chalcogen molecular entity [CHEBI:33304] (15225) 
 oxygen molecular entity [CHEBI:25806] (14414) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 polyene antibiotic [CHEBI:26177] (10) 
 TMC-1A [CHEBI:66234] (1)
 alcohol [CHEBI:30879] (1371) 
 tertiary alcohol [CHEBI:26878] (183) 
 TMC-1A [CHEBI:66234] (1)
 secondary alcohol [CHEBI:35681] (342) 
 TMC-1A [CHEBI:66234] (1)
 enol [CHEBI:33823] (52) 
 TMC-1A [CHEBI:66234] (1)
 organooxygen compound [CHEBI:36963] (11352) 
 carbonyl compound [CHEBI:36586] (5928) 
 ketone [CHEBI:17087] (1288) 
 cyclic ketone [CHEBI:3992] (644) 
 TMC-1A [CHEBI:66234] (1)
 alpha,beta-unsaturated ketone [CHEBI:51721] (238) 
 enone [CHEBI:51689] (233) 
 TMC-1A [CHEBI:66234] (1)
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 organochalcogen compound [CHEBI:36962] (11874) 
 organooxygen compound [CHEBI:36963] (11352) 
 carbonyl compound [CHEBI:36586] (5928) 
 ketone [CHEBI:17087] (1288) 
 cyclic ketone [CHEBI:3992] (644) 
 TMC-1A [CHEBI:66234] (1)
 alpha,beta-unsaturated ketone [CHEBI:51721] (238) 
 enone [CHEBI:51689] (233) 
 TMC-1A [CHEBI:66234] (1)
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 carbon group molecular entity [CHEBI:33582] (23847) 
 organic molecular entity [CHEBI:50860] (23769) 
 heteroorganic entity [CHEBI:33285] (15197) 
 organonitrogen compound [CHEBI:35352] (6705) 
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 organochalcogen compound [CHEBI:36962] (11874) 
 organooxygen compound [CHEBI:36963] (11352) 
 carbonyl compound [CHEBI:36586] (5928) 
 ketone [CHEBI:17087] (1288) 
 cyclic ketone [CHEBI:3992] (644) 
 TMC-1A [CHEBI:66234] (1)
 alpha,beta-unsaturated ketone [CHEBI:51721] (238) 
 enone [CHEBI:51689] (233) 
 TMC-1A [CHEBI:66234] (1)
 carboxamide [CHEBI:37622] (1381) 
 TMC-1A [CHEBI:66234] (1)
 organic hydroxy compound [CHEBI:33822] (3050) 
 polyene antibiotic [CHEBI:26177] (10) 
 TMC-1A [CHEBI:66234] (1)
 alcohol [CHEBI:30879] (1371) 
 tertiary alcohol [CHEBI:26878] (183) 
 TMC-1A [CHEBI:66234] (1)
 secondary alcohol [CHEBI:35681] (342) 
 TMC-1A [CHEBI:66234] (1)
 enol [CHEBI:33823] (52) 
 TMC-1A [CHEBI:66234] (1)
 organic molecule [CHEBI:72695] (11399) 
 organic oxo compound [CHEBI:36587] (5932) 
 carbonyl compound [CHEBI:36586] (5928) 
 ketone [CHEBI:17087] (1288) 
 cyclic ketone [CHEBI:3992] (644) 
 TMC-1A [CHEBI:66234] (1)
 alpha,beta-unsaturated ketone [CHEBI:51721] (238) 
 enone [CHEBI:51689] (233) 
 TMC-1A [CHEBI:66234] (1)
 polyatomic entity [CHEBI:36357] (18777) 
 molecule [CHEBI:25367] (11520) 
 organic molecule [CHEBI:72695] (11399) 
 organic oxo compound [CHEBI:36587] (5932) 
 carbonyl compound [CHEBI:36586] (5928) 
 ketone [CHEBI:17087] (1288) 
 cyclic ketone [CHEBI:3992] (644) 
 TMC-1A [CHEBI:66234] (1)
 alpha,beta-unsaturated ketone [CHEBI:51721] (238) 
 enone [CHEBI:51689] (233) 
 TMC-1A [CHEBI:66234] (1)
 heteroatomic molecular entity [CHEBI:37577] (13672) 
 hydroxides [CHEBI:24651] (5641) 
 organic hydroxy compound [CHEBI:33822] (3050) 
 polyene antibiotic [CHEBI:26177] (10) 
 TMC-1A [CHEBI:66234] (1)
 alcohol [CHEBI:30879] (1371) 
 tertiary alcohol [CHEBI:26878] (183) 
 TMC-1A [CHEBI:66234] (1)
 secondary alcohol [CHEBI:35681] (342) 
 TMC-1A [CHEBI:66234] (1)
 enol [CHEBI:33823] (52) 
 TMC-1A [CHEBI:66234] (1)
ChEBI Compound Accession Identifier:   [CHEBI:66234]
ChEBI Compound Description:   A polyene antibiotic that is hexa-1,3,5-triene substituted at position 1 by a cyclohex-1-en-1-yl group which is substituted by a (2,4-dimethyloct-2-enoyl)amino group, hydroxy groups and oxo group at positions 1, 3, 4 and 6 respectively and at position 6 by a N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)formamyl group. It is an antitumour antibiotic isolated from Streptomyces sp. A-230.
ChEBI Compound Identification Number:   66234
ChEBI InChI Value:   InChI=1S/C28H36N2O7/c1-4-5-10-18(2)15-19(3)27(36)29-20-17-28(37,24(34)16-23(20)33)14-9-7-6-8-11-25(35)30-26-21(31)12-13-22(26)32/h6-9,11,14-15,17-18,24,31,34,37H,4-5,10,12-13,16H2,1-3H3,(H,29,36)(H,30,35)/b7-6+,11-8+,14-9+,19-15+/t18?,24-,28+/m1/s1
ChEBI InChIKey Value:   CCZRQXWCDVXNHR-GFLRHUPZSA-N
ChEBI Compound Name:   TMC-1A
ChEBI SMILES Value:   CCCCC(C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@H](O)CC1=O
ChEBI Substance ID:   160645198
ChEBI URL:   ChEBI:66234
ChemSpider ID:   8567133
Ontomatica Chemical Accession Key (OnChAKey):   CCZRQXWCDVXNHR_GFLRHUPZSA_N_000_000000
PubChem Compound ID:   10391691