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 chymostatin
C002101
 
  
  
  

MeSH Unique Identifier: C002101
Chemical – Gene Interaction

Note 1: Chymostatin results in decreased activity of KLK8 protein

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C25. Chemically-Induced Disorders: Substance-Related Disorders [MESH:D019966] > Drug Overdose [MESH:D062787]
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2. Interaction: Human Genes and Chemicals 
2. Interaction: Human Genes and Chemicals
 Decreases (5154) 
 activity (2549)
4. Semantic Terms 
4. Semantic Terms
 Entity [STY:T071] (48056) 
 Physical Object [STY:T072] (47583) 
 Substance [STY:T167] (46174) 
 Chemical [STY:T103] (46110) 
 Chemical Viewed Functionally [STY:T120] (28747) 
 Pharmacologic Substance [STY:T121] (11019)
 Chemical Viewed Structurally [STY:T104] (44741) 
 Organic Chemical [STY:T109] (44144) 
 Amino Acid, Peptide, or Protein [STY:T116] (18497)
A. Anatomy 
A. Anatomy
 Urogenital System [MESH:D014566] (986) 
 Urinary Tract [MESH:D014551] (721) 
 Kidney [MESH:D007668] (707) 
 Nephrons [MESH:D009399] (518) 
 Kidney Tubules [MESH:D007684] (510) 
 Kidney Tubules, Proximal [MESH:D007687] (504) 
 Allanson Pantzar McLeod syndrome [MESH:C537048] (503)
C06. Digestive System Diseases 
C06. Digestive System Diseases
 Digestive System Diseases [MESH:D004066] (9461) 
 Gastrointestinal Diseases [MESH:D005767] (7443) 
 Gastrointestinal Hemorrhage [MESH:D006471] (815) 
 Peptic Ulcer Hemorrhage [MESH:D010438] (553)
 Liver Diseases [MESH:D008107] (8167) 
 Liver Cirrhosis [MESH:D008103] (5542) 
 Liver Cirrhosis, Experimental [MESH:D008106] (4589)
C10. Nervous System Diseases 
C10. Nervous System Diseases
 Nervous System Diseases [MESH:D009422] (13325) 
 Central Nervous System Diseases [MESH:D002493] (9745) 
 Brain Diseases [MESH:D001927] (9294) 
 Cerebrovascular Disorders [MESH:D002561] (5542) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Epilepsy [MESH:D004827] (6274) 
 Seizures [MESH:D012640] (4502)
 Neurologic Manifestations [MESH:D009461] (8964) 
 Seizures [MESH:D012640] (4514)
 Dyskinesias [MESH:D020820] (3365) 
 Catalepsy [MESH:D002375] (1429)
 Sensation Disorders [MESH:D012678] (5011) 
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
C11. Eye Diseases 
C11. Eye Diseases
 Eye Diseases [MESH:D005128] (6245) 
 Retinal Diseases [MESH:D012164] (3747) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Retinopathy of Prematurity [MESH:D012178] (353)
C12. Male Urogenital Diseases 
C12. Male Urogenital Diseases
 Male Urogenital Diseases [MESH:D052801] (8891) 
 Urogenital Abnormalities [MESH:D014564] (2065) 
 Allanson Pantzar McLeod syndrome [MESH:C537048] (503)
 Urologic Diseases [MESH:D014570] (7792) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hypertension, Renal [MESH:D006977] (698)
 Nephrosis [MESH:D009401] (2228)
 Renal Insufficiency [MESH:D051437] (4951)
 Nephritis [MESH:D009393] (4236) 
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, IGA [MESH:D005922] (897)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
C13. Female Urogenital Diseases and Pregnancy Complications 
C13. Female Urogenital Diseases and Pregnancy Complications
 Female Urogenital Diseases [MESH:D052776] (8724) 
 Urogenital Abnormalities [MESH:D014564] (2043) 
 Allanson Pantzar McLeod syndrome [MESH:C537048] (503)
 Urologic Diseases [MESH:D014570] (7793) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hypertension, Renal [MESH:D006977] (698)
 Nephrosis [MESH:D009401] (2228)
 Renal Insufficiency [MESH:D051437] (4951)
 Nephritis [MESH:D009393] (4236) 
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, IGA [MESH:D005922] (897)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
 Pregnancy Complications [MESH:D011248] (4768) 
 Fetal Diseases [MESH:D005315] (1206) 
 Fetal Growth Retardation [MESH:D005317] (986)
 Hypertension, Pregnancy-Induced [MESH:D046110] (1453) 
 Pre-Eclampsia [MESH:D011225] (1435)
C14. Cardiovascular Diseases 
C14. Cardiovascular Diseases
 Z. Exceptions (2667) 
 Not Fully Specified [NFS] (2667)
 Cardiovascular Diseases [MESH:D002318] (10123) 
 Heart Diseases [MESH:D006331] (8614) 
 Heart Failure [MESH:D006333] (4058)
 Arrhythmias, Cardiac [MESH:D001145] (4679) 
 Bradycardia [MESH:D001919] (1899)
 Cardiomegaly [MESH:D006332] (4081) 
 Hypertrophy, Left Ventricular [MESH:D017379] (1430)
 Cardiomyopathies [MESH:D009202] (5331) 
 Cardiomyopathy, Alcoholic [MESH:D002310] (354)
 Endomyocardial Fibrosis [MESH:D004719] (521)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Myocardial Ischemia [MESH:D017202] (5787) 
 Myocardial Infarction [MESH:D009203] (4122)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Vascular Diseases [MESH:D014652] (8691) 
 Hyperemia [MESH:D006940] (2372)
 Hypotension [MESH:D007022] (4045)
 Aneurysm [MESH:D000783] (1886) 
 Aneurysm, Dissecting [MESH:D000784] (699)
 Aortic Aneurysm [MESH:D001014] (1721) 
 Aortic Aneurysm, Abdominal [MESH:D017544] (1519)
 Aortic Diseases [MESH:D001018] (1737) 
 Aortic Aneurysm [MESH:D001014] (1721) 
 Aortic Aneurysm, Abdominal [MESH:D017544] (1519)
 Arterial Occlusive Diseases [MESH:D001157] (4520) 
 Arteriosclerosis [MESH:D001161] (4466) 
 Atherosclerosis [MESH:D050197] (4188)
 Cerebrovascular Disorders [MESH:D002561] (5541) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Embolism and Thrombosis [MESH:D016769] (3374) 
 Thrombosis [MESH:D013927] (3101)
 Hypertension [MESH:D006973] (5655) 
 Hypertension, Essential [MESH:C562386] (1308)
 Hypertension, Malignant [MESH:D006974] (621)
 Hypertension, Renal [MESH:D006977] (698)
 Myocardial Ischemia [MESH:D017202] (5791) 
 Myocardial Infarction [MESH:D009203] (4151)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
C15. Hemic and Lymphatic Diseases 
C15. Hemic and Lymphatic Diseases
 Hematologic Diseases [MESH:D006402] (6174) 
 Anemia [MESH:D000740] (3966)
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities 
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152) 
 Congenital Abnormalities [MESH:D000013] (8109) 
 Urogenital Abnormalities [MESH:D014564] (2064) 
 Allanson Pantzar McLeod syndrome [MESH:C537048] (503)
 Fetal Diseases [MESH:D005315] (1205) 
 Fetal Growth Retardation [MESH:D005317] (986)
 Infant, Newborn, Diseases [MESH:D007232] (3064) 
 Infant, Premature, Diseases [MESH:D007235] (1292) 
 Retinopathy of Prematurity [MESH:D012178] (353)
C18. Nutritional and Metabolic Diseases 
C18. Nutritional and Metabolic Diseases
 Metabolic Diseases [MESH:D008659] (9025) 
 Acid-Base Imbalance [MESH:D000137] (854) 
 Alkalosis [MESH:D000471] (384)
 Glucose Metabolism Disorders [MESH:D044882] (6122) 
 Diabetes Mellitus [MESH:D003920] (5891) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Water-Electrolyte Imbalance [MESH:D014883] (2790) 
 Hypokalemia [MESH:D007008] (1041)
C19. Endocrine System Diseases 
C19. Endocrine System Diseases
 Endocrine System Diseases [MESH:D004700] (8062) 
 Diabetes Mellitus [MESH:D003920] (6159) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Complications [MESH:D048909] (4129) 
 Diabetic Nephropathies [MESH:D003928] (2301)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
C20. Immune System Diseases 
C20. Immune System Diseases
 Immune System Diseases [MESH:D007154] (7674) 
 Autoimmune Diseases [MESH:D001327] (5067) 
 Glomerulonephritis, IGA [MESH:D005922] (897)
C23. Pathological Conditions, Signs and Symptoms 
C23. Pathological Conditions, Signs and Symptoms
 Pathological Conditions, Anatomical [MESH:D020763] (6074) 
 Hernia [MESH:D006547] (2825) 
 Hernia, Diaphragmatic [MESH:D006548] (2647)
 Hypertrophy [MESH:D006984] (4476) 
 Cardiomegaly [MESH:D006332] (3802) 
 Hypertrophy, Left Ventricular [MESH:D017379] (1430)
 Pathologic Processes [MESH:D010335] (9863) 
 Fibrosis [MESH:D005355] (3133)
 Inflammation [MESH:D007249] (5241)
 Necrosis [MESH:D009336] (4019)
 Neointima [MESH:D058426] (814)
 Arrhythmias, Cardiac [MESH:D001145] (4658) 
 Bradycardia [MESH:D001919] (1899)
 Death [MESH:D003643] (1328) 
 Death, Sudden [MESH:D003645] (725)
 Growth Disorders [MESH:D006130] (2438) 
 Fetal Growth Retardation [MESH:D005317] (986)
 Hemorrhage [MESH:D006470] (4451) 
 Gastrointestinal Hemorrhage [MESH:D006471] (815) 
 Peptic Ulcer Hemorrhage [MESH:D010438] (553)
 Postoperative Complications [MESH:D011183] (5311) 
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Signs and Symptoms [MESH:D012816] (10659) 
 Neurologic Manifestations [MESH:D009461] (8702) 
 Seizures [MESH:D012640] (4502)
 Dyskinesias [MESH:D020820] (3285) 
 Catalepsy [MESH:D002375] (1429)
 Sensation Disorders [MESH:D012678] (5009) 
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Urological Manifestations [MESH:D020924] (3532) 
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
C25. Chemically-Induced Disorders 
C25. Chemically-Induced Disorders
 Substance-Related Disorders [MESH:D019966] (6308) 
 Drug Overdose [MESH:D062787] (513)
 Alcohol-Related Disorders [MESH:D019973] (3869) 
 Alcohol-Induced Disorders [MESH:D020751] (3350) 
 Cardiomyopathy, Alcoholic [MESH:D002310] (354)
D12. Amino Acids, Peptides, and Proteins 
D12. Amino Acids, Peptides, and Proteins
 Peptides [MESH:D010455] (20561) 
 Oligopeptides [MESH:D009842] (4990)