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 diazoxon
C000912
 
  
  
  

MeSH Unique Identifier: C000912
Scope Notes: A pesticide
Chemical – Gene Interaction

Note 1: ALB protein results in decreased susceptibility to diazoxon

Note 2: ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein]

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C25. Chemically-Induced Disorders: Poisoning [MESH:D011041] > Organophosphate Poisoning [MESH:D062025]
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1. Human Genes 
1. Human Genes
 Paraoxonases [HGNC:PON] (134) 
 paraoxonase 1 [HGNC:PON1] (115)
2. Interaction: Human Genes and Chemicals 
2. Interaction: Human Genes and Chemicals
 Affects (3990) 
 binding (2423)
 hydrolysis (14)
 metabolic processing (485)
 reaction (624)
 Decreases (5154) 
 activity (2549)
 hydrolysis (6)
 response to substance (713)
 Increases (5571) 
 hydrolysis (158)
C01. Bacterial Infections and Mycoses 
C01. Bacterial Infections and Mycoses
 Bacterial Infections [MESH:D001424] (3716) 
 Gram-Positive Bacterial Infections [MESH:D016908] (2434) 
 Actinomycetales Infections [MESH:D000193] (1466) 
 Mycobacterium Infections [MESH:D009164] (1446) 
 Tuberculosis [MESH:D014376] (992) 
 Tuberculosis, Pulmonary [MESH:D014397] (678)
C02. Virus Diseases 
C02. Virus Diseases
 Virus Diseases [MESH:D014777] (4544) 
 Central Nervous System Viral Diseases [MESH:D020805] (1416) 
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 RNA Virus Infections [MESH:D012327] (4215) 
 Orthomyxoviridae Infections [MESH:D009976] (1077) 
 Influenza, Human [MESH:D007251] (1075)
 Retroviridae Infections [MESH:D012192] (3420) 
 Lentivirus Infections [MESH:D016180] (3408) 
 HIV Infections [MESH:D015658] (3402) 
 HIV Seropositivity [MESH:D006679] (480)
 Sexually Transmitted Diseases [MESH:D012749] (3305) 
 Sexually Transmitted Diseases, Viral [MESH:D015229] (3304) 
 HIV Infections [MESH:D015658] (3296) 
 HIV Seropositivity [MESH:D006679] (480)
C03. Parasitic Diseases 
C03. Parasitic Diseases
 Parasitic Diseases [MESH:D010272] (3828) 
 Protozoan Infections [MESH:D011528] (3014) 
 Euglenozoa Infections [MESH:D056986] (2552) 
 Leishmaniasis [MESH:D007896] (2541) 
 Leishmaniasis, Cutaneous [MESH:D016773] (2359)
 Skin Diseases, Parasitic [MESH:D012876] (2541) 
 Leishmaniasis [MESH:D007896] (2516) 
 Leishmaniasis, Cutaneous [MESH:D016773] (2359)
C04. Neoplasms 
C04. Neoplasms
 Neoplasms [MESH:D009369] (10293) 
 Neoplasms by Histologic Type [MESH:D009370] (8793) 
 Neoplasms, Connective and Soft Tissue [MESH:D018204] (4742) 
 Neoplasms, Muscle Tissue [MESH:D009379] (1965) 
 Myosarcoma [MESH:D009217] (790) 
 Rhabdomyosarcoma [MESH:D012208] (789)
 Sarcoma [MESH:D012509] (4246) 
 Myosarcoma [MESH:D009217] (790) 
 Rhabdomyosarcoma [MESH:D012208] (789)
 Neoplasms, Germ Cell and Embryonal [MESH:D009373] (5126) 
 Neuroectodermal Tumors [MESH:D017599] (5066) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Glandular and Epithelial [MESH:D009375] (7760) 
 Carcinoma [MESH:D002277] (7263) 
 Adenocarcinoma [MESH:D000230] (6565) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Nerve Tissue [MESH:D009380] (5201) 
 Neuroectodermal Tumors [MESH:D017599] (5059) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Plasma Cell [MESH:D054219] (2772) 
 Multiple Myeloma [MESH:D009101] (2767)
 Neoplasms by Site [MESH:D009371] (9169) 
 Digestive System Neoplasms [MESH:D004067] (7487) 
 Liver Neoplasms [MESH:D008113] (6048)
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Gastrointestinal Neoplasms [MESH:D005770] (6452) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5358) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Nervous System Neoplasms [MESH:D009423] (3130) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Thoracic Neoplasms [MESH:D013899] (6032) 
 Respiratory Tract Neoplasms [MESH:D012142] (6020) 
 Lung Neoplasms [MESH:D008175] (6015) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Urogenital Neoplasms [MESH:D014565] (7002) 
 Genital Neoplasms, Female [MESH:D005833] (2540) 
 Uterine Neoplasms [MESH:D014594] (2431) 
 Endometrial Neoplasms [MESH:D016889] (1987)
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
C05. Musculoskeletal Diseases 
C05. Musculoskeletal Diseases
 Musculoskeletal Diseases [MESH:D009140] (8705) 
 Jaw Diseases [MESH:D007571] (1601) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Joint Diseases [MESH:D007592] (4657) 
 Arthritis [MESH:D001168] (4416) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Muscular Diseases [MESH:D009135] (4071) 
 Muscle Spasticity [MESH:D009128] (187)
 Muscular Disorders, Atrophic [MESH:D020966] (1598) 
 Muscular Dystrophies [MESH:D009136] (1593) 
 Muscular Dystrophy, Duchenne [MESH:D020388] (942)
 Musculoskeletal Abnormalities [MESH:D009139] (3796) 
 Craniofacial Abnormalities [MESH:D019465] (3098) 
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Rheumatic Diseases [MESH:D012216] (4032) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
C06. Digestive System Diseases 
C06. Digestive System Diseases
 Digestive System Diseases [MESH:D004066] (9461) 
 Biliary Tract Diseases [MESH:D001660] (3845) 
 Bile Duct Diseases [MESH:D001649] (3512) 
 Cholestasis [MESH:D002779] (3419) 
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Digestive System Neoplasms [MESH:D004067] (7493) 
 Liver Neoplasms [MESH:D008113] (6048)
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Gastrointestinal Diseases [MESH:D005767] (7443) 
 Gastroenteritis [MESH:D005759] (4066) 
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Crohn Disease [MESH:D003424] (2585)
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Intestinal Diseases [MESH:D007410] (6206) 
 Colonic Diseases [MESH:D003108] (5564) 
 Colorectal Neoplasms [MESH:D015179] (5282) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Crohn Disease [MESH:D003424] (2585)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Rectal Diseases [MESH:D012002] (4596) 
 Hemorrhoids [MESH:D006484] (166)
 Stomach Diseases [MESH:D013272] (5325) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Liver Diseases [MESH:D008107] (8167) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Fatty Liver [MESH:D005234] (3584)
 Liver Neoplasms [MESH:D008113] (6048)
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Hepatic Insufficiency [MESH:D048550] (2771) 
 Liver Failure [MESH:D017093] (2768) 
 Liver Failure, Acute [MESH:D017114] (2404)
 Hepatitis [MESH:D006505] (3883) 
 Hepatitis, Chronic [MESH:D006521] (2071) 
 Hepatitis, Autoimmune [MESH:D019693] (1982)
 Liver Cirrhosis [MESH:D008103] (5542) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Liver Cirrhosis, Experimental [MESH:D008106] (4589)
 Pancreatic Diseases [MESH:D010182] (4453) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Pancreatitis [MESH:D010195] (1924)
C07. Stomatognathic Diseases 
C07. Stomatognathic Diseases
 Stomatognathic Diseases [MESH:D009057] (5348) 
 Jaw Diseases [MESH:D007571] (1608) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Mouth Diseases [MESH:D009059] (4783) 
 Behcet Syndrome [MESH:D001528] (1784)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Stomatitis [MESH:D013280] (1235) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Stomatognathic System Abnormalities [MESH:D018640] (1705) 
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
C08. Respiratory Tract Diseases 
C08. Respiratory Tract Diseases
 Z. Exceptions (1984) 
 Not Fully Specified [NFS] (1984)
 Respiratory Tract Diseases [MESH:D012140] (7881) 
 Pleural Diseases [MESH:D010995] (2240)
 Bronchial Diseases [MESH:D001982] (4382) 
 Asthma [MESH:D001249] (4098)
 Bronchial Hyperreactivity [MESH:D016535] (1357)
 Lung Diseases [MESH:D008171] (7249) 
 Hypertension, Pulmonary [MESH:D006976] (2000)
 Lung Injury [MESH:D055370] (3688)
 Pneumonia [MESH:D011014] (3482)
 Pulmonary Fibrosis [MESH:D011658] (3140)
 Respiratory Distress Syndrome, Adult [MESH:D012128] (864)
 Tuberculosis, Pulmonary [MESH:D014397] (678)
 Lung Diseases, Obstructive [MESH:D008173] (4697) 
 Asthma [MESH:D001249] (3903)
 Lung Neoplasms [MESH:D008175] (6012) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Nose Diseases [MESH:D009668] (1504) 
 Rhinitis [MESH:D012220] (1134) 
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Respiration Disorders [MESH:D012120] (2218) 
 Respiratory Distress Syndrome, Adult [MESH:D012128] (864)
 Apnea [MESH:D001049] (748) 
 Sleep Apnea Syndromes [MESH:D012891] (570)
 Respiratory Hypersensitivity [MESH:D012130] (4401) 
 Asthma [MESH:D001249] (4098)
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Respiratory Tract Infections [MESH:D012141] (3926) 
 Influenza, Human [MESH:D007251] (1075)
 Pneumonia [MESH:D011014] (3482)
 Tuberculosis, Pulmonary [MESH:D014397] (678)
 Respiratory Tract Neoplasms [MESH:D012142] (6053) 
 Lung Neoplasms [MESH:D008175] (6013) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
C09. Otorhinolaryngologic Diseases 
C09. Otorhinolaryngologic Diseases
 Otorhinolaryngologic Diseases [MESH:D010038] (3827) 
 Nose Diseases [MESH:D009668] (1504) 
 Rhinitis [MESH:D012220] (1134) 
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
C10. Nervous System Diseases 
C10. Nervous System Diseases
 Z. Exceptions (4027) 
 Not Fully Specified [NFS] (4027)
 Nervous System Diseases [MESH:D009422] (13325) 
 Neurotoxicity Syndromes [MESH:D020258] (4570)
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Central Nervous System Diseases [MESH:D002493] (9745) 
 Brain Diseases [MESH:D001927] (9294) 
 Brain Injuries [MESH:D001930] (3429)
 Brain Neoplasms [MESH:D001932] (2764)
 Basal Ganglia Diseases [MESH:D001480] (4268) 
 Huntington Disease [MESH:D006816] (540)
 Cerebrovascular Disorders [MESH:D002561] (5542) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Brain Ischemia [MESH:D002545] (4873) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2463) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Dementia [MESH:D003704] (4498) 
 Huntington Disease [MESH:D006816] (540)
 Epilepsy [MESH:D004827] (6274) 
 Seizures [MESH:D012640] (4502)
 Status Epilepticus [MESH:D013226] (4014)
 Epilepsies, Partial [MESH:D004828] (1267) 
 Epilepsy, Temporal Lobe [MESH:D004833] (1108)
 Epilepsy, Generalized [MESH:D004829] (1431) 
 Epilepsy, Tonic-Clonic [MESH:D004830] (1042)
 Central Nervous System Infections [MESH:D002494] (1823) 
 Central Nervous System Viral Diseases [MESH:D020805] (1416) 
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Meningitis [MESH:D008581] (1506) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Movement Disorders [MESH:D009069] (4823) 
 Dyskinesias [MESH:D020820] (1827) 
 Chorea [MESH:D002819] (651) 
 Huntington Disease [MESH:D006816] (540)
 Spinal Cord Diseases [MESH:D013118] (4376) 
 Spinal Cord Compression [MESH:D013117] (1800)
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic Lateral Sclerosis, Sporadic [MESH:C566291] (239)
 Demyelinating Diseases [MESH:D003711] (2917) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (2035) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143) 
 Spinal Dysraphism [MESH:D016135] (1025)
 Nervous System Neoplasms [MESH:D009423] (3073) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Neurodegenerative Diseases [MESH:D019636] (6613) 
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3243) 
 Huntington Disease [MESH:D006816] (540)
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic Lateral Sclerosis, Sporadic [MESH:C566291] (239)
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic Lateral Sclerosis, Sporadic [MESH:C566291] (239)
 Neurologic Manifestations [MESH:D009461] (8964) 
 Pain [MESH:D010146] (3875)
 Paralysis [MESH:D010243] (2043)
 Paresis [MESH:D010291] (419)
 Seizures [MESH:D012640] (4514)
 Dyskinesias [MESH:D020820] (3365) 
 Catalepsy [MESH:D002375] (1429)
 Hyperkinesis [MESH:D006948] (1799)
 Tremor [MESH:D014202] (840)
 Neurobehavioral Manifestations [MESH:D019954] (5230) 
 Memory Disorders [MESH:D008569] (3233)
 Communication Disorders [MESH:D003147] (2918) 
 Learning Disorders [MESH:D007859] (2727)
 Neuromuscular Manifestations [MESH:D020879] (2130) 
 Fasciculation [MESH:D005207] (204)
 Muscle Hypertonia [MESH:D009122] (775) 
 Muscle Spasticity [MESH:D009128] (187)
 Spasm [MESH:D013035] (418) 
 Trismus [MESH:D014313] (221)
 Sensation Disorders [MESH:D012678] (5011) 
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Neuromuscular Diseases [MESH:D009468] (7336) 
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic Lateral Sclerosis, Sporadic [MESH:C566291] (239)
 Muscular Diseases [MESH:D009135] (3538) 
 Muscular Disorders, Atrophic [MESH:D020966] (1594) 
 Muscular Dystrophies [MESH:D009136] (1589) 
 Muscular Dystrophy, Duchenne [MESH:D020388] (942)
 Sleep Disorders [MESH:D012893] (2050) 
 Dyssomnias [MESH:D020920] (1417) 
 Sleep Disorders, Intrinsic [MESH:D020919] (1270) 
 Sleep Apnea Syndromes [MESH:D012891] (570)
 Trauma, Nervous System [MESH:D020196] (3997) 
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
C11. Eye Diseases 
C11. Eye Diseases
 Eye Diseases [MESH:D005128] (6245) 
 Retinal Diseases [MESH:D012164] (3747) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Uveal Diseases [MESH:D014603] (2428) 
 Uveitis [MESH:D014605] (2157) 
 Panuveitis [MESH:D015864] (1805) 
 Uveitis, Anterior [MESH:D014606] (1791) 
 Behcet Syndrome [MESH:D001528] (1784)
C12. Male Urogenital Diseases 
C12. Male Urogenital Diseases
 Male Urogenital Diseases [MESH:D052801] (8891) 
 Genital Diseases, Male [MESH:D005832] (6794) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Infertility [MESH:D007246] (2909) 
 Infertility, Male [MESH:D007248] (2851)
 Prostatic Diseases [MESH:D011469] (6204) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urogenital Neoplasms [MESH:D014565] (6932) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7792) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hyperoxaluria [MESH:D006959] (1498)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Nephritis [MESH:D009393] (4236) 
 Nephritis, Interstitial [MESH:D009395] (1927)
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770)
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Nephrosis [MESH:D009401] (2228) 
 Nephrotic Syndrome [MESH:D009404] (1536)
 Renal Insufficiency [MESH:D051437] (4951) 
 Acute Kidney Injury [MESH:D058186] (4142)
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Uremia [MESH:D014511] (2898) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Urinary Bladder Diseases [MESH:D001745] (4374) 
 Cystitis [MESH:D003556] (604) 
 Cystitis, Interstitial [MESH:D018856] (264)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293)
C13. Female Urogenital Diseases and Pregnancy Complications 
C13. Female Urogenital Diseases and Pregnancy Complications
 Female Urogenital Diseases [MESH:D052776] (8724) 
 Genital Diseases, Female [MESH:D005831] (5563) 
 Endometriosis [MESH:D004715] (2461)
 Uterine Diseases [MESH:D014591] (2479) 
 Uterine Neoplasms [MESH:D014594] (2430) 
 Endometrial Neoplasms [MESH:D016889] (1984)
 Urogenital Neoplasms [MESH:D014565] (5792) 
 Genital Neoplasms, Female [MESH:D005833] (3810) 
 Uterine Neoplasms [MESH:D014594] (2433) 
 Endometrial Neoplasms [MESH:D016889] (1989)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7793) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hyperoxaluria [MESH:D006959] (1498)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Nephritis [MESH:D009393] (4236) 
 Nephritis, Interstitial [MESH:D009395] (1927)
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770)
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Nephrosis [MESH:D009401] (2228) 
 Nephrotic Syndrome [MESH:D009404] (1536)
 Renal Insufficiency [MESH:D051437] (4951) 
 Acute Kidney Injury [MESH:D058186] (4142)
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Uremia [MESH:D014511] (2898) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Urinary Bladder Diseases [MESH:D001745] (4375) 
 Cystitis [MESH:D003556] (604) 
 Cystitis, Interstitial [MESH:D018856] (264)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293)
 Pregnancy Complications [MESH:D011248] (4768) 
 Abortion, Spontaneous [MESH:D000022] (2780)
 Prenatal Injuries [MESH:D049188] (1314)
 Hypertension, Pregnancy-Induced [MESH:D046110] (1453) 
 Pre-Eclampsia [MESH:D011225] (1435)
 Obstetric Labor Complications [MESH:D007744] (1550) 
 Obstetric Labor, Premature [MESH:D007752] (1316)
C14. Cardiovascular Diseases 
C14. Cardiovascular Diseases
 Z. Exceptions (2667) 
 Not Fully Specified [NFS] (2667)
 Cardiovascular Diseases [MESH:D002318] (10123) 
 Heart Diseases [MESH:D006331] (8614) 
 Heart Failure [MESH:D006333] (4058)
 Heart Valve Diseases [MESH:D006349] (3333)
 Arrhythmias, Cardiac [MESH:D001145] (4679) 
 Tachycardia [MESH:D013610] (3339)
 Cardiomyopathies [MESH:D009202] (5331) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Myocardial Ischemia [MESH:D017202] (5787) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Coronary Disease [MESH:D003327] (3439) 
 Coronary Artery Disease [MESH:D003324] (2685)
 Coronary Vasospasm [MESH:D003329] (533)
 Vascular Diseases [MESH:D014652] (8691) 
 Angioedema [MESH:D000799] (837)
 Arteritis [MESH:D001167] (1084)
 Hemorrhoids [MESH:D006484] (166)
 Hypertension [MESH:D006973] (5655)
 Hypotension [MESH:D007022] (4045)
 Arterial Occlusive Diseases [MESH:D001157] (4520) 
 Arteriosclerosis [MESH:D001161] (4466) 
 Atherosclerosis [MESH:D050197] (4188)
 Coronary Artery Disease [MESH:D003324] (2685)
 Cerebrovascular Disorders [MESH:D002561] (5541) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Brain Ischemia [MESH:D002545] (4873) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2468) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Embolism and Thrombosis [MESH:D016769] (3374) 
 Thrombosis [MESH:D013927] (3101)
 Hemostatic Disorders [MESH:D020141] (2894) 
 Multiple Myeloma [MESH:D009101] (2765)
 Myocardial Ischemia [MESH:D017202] (5791) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Coronary Disease [MESH:D003327] (3439) 
 Coronary Artery Disease [MESH:D003324] (2685)
 Coronary Vasospasm [MESH:D003329] (533)
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Vasculitis [MESH:D014657] (2604) 
 Arteritis [MESH:D001167] (1084)
 Behcet Syndrome [MESH:D001528] (1784)
C15. Hemic and Lymphatic Diseases 
C15. Hemic and Lymphatic Diseases
 Hematologic Diseases [MESH:D006402] (6174) 
 Anemia [MESH:D000740] (3966) 
 Anemia, Hemolytic [MESH:D000743] (3083) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Blood Platelet Disorders [MESH:D001791] (3174) 
 Thrombocytopenia [MESH:D013921] (2966) 
 Thrombotic Microangiopathies [MESH:D057049] (2598) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Blood Protein Disorders [MESH:D001796] (3051) 
 Hypoproteinemia [MESH:D007019] (1335) 
 Hypoalbuminemia [MESH:D034141] (1332)
 Paraproteinemias [MESH:D010265] (2781) 
 Multiple Myeloma [MESH:D009101] (2765)
 Hemorrhagic Disorders [MESH:D006474] (3359) 
 Plasminogen Activator Inhibitor-1 Deficiency [MESH:C567640] (328)
 Hemostatic Disorders [MESH:D020141] (2932) 
 Multiple Myeloma [MESH:D009101] (2765)
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities 
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152) 
 Congenital Abnormalities [MESH:D000013] (8109) 
 Abnormalities, Multiple [MESH:D000015] (3192) 
 Bamforth syndrome [MESH:C537901] (186)
 Musculoskeletal Abnormalities [MESH:D009139] (3779) 
 Craniofacial Abnormalities [MESH:D019465] (3064) 
 Maxillofacial Abnormalities [MESH:D019767] (1448) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143) 
 Spinal Dysraphism [MESH:D016135] (1025)
 Stomatognathic System Abnormalities [MESH:D018640] (1705) 
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Bamforth syndrome [MESH:C537901] (186)
 Genetic Diseases, Inborn [MESH:D030342] (9766) 
 Hyperthyroxinemia, Familial Dysalbuminemic [MESH:D050010] (478)
 Genetic Diseases, X-Linked [MESH:D040181] (3028) 
 Muscular Dystrophy, Duchenne [MESH:D020388] (942)
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3465) 
 Huntington Disease [MESH:D006816] (540)
 Metabolism, Inborn Errors [MESH:D008661] (6032) 
 Butyrylcholinesterase deficiency [MESH:C537417] (176)
 Amino Acid Metabolism, Inborn Errors [MESH:D000592] (2565) 
 Hyperhomocysteinemia [MESH:D020138] (1724)
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Muscular Dystrophies [MESH:D009136] (1597) 
 Muscular Dystrophy, Duchenne [MESH:D020388] (942)
 Skin Diseases, Genetic [MESH:D012873] (3456) 
 Dermatitis, Atopic [MESH:D003876] (2052)
C17. Skin and Connective Tissue Diseases 
C17. Skin and Connective Tissue Diseases
 Connective Tissue Diseases [MESH:D003240] (4490) 
 Collagen Diseases [MESH:D003095] (1267) 
 Keloid [MESH:D007627] (1111)
 Rheumatic Diseases [MESH:D012216] (3619) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Skin Diseases [MESH:D012871] (8774) 
 Dermatitis [MESH:D003872] (4530) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Drug Eruptions [MESH:D003875] (2697) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Erythema [MESH:D004890] (1330) 
 Erythema Multiforme [MESH:D004892] (1185) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Hair Diseases [MESH:D006201] (1891) 
 Bamforth syndrome [MESH:C537901] (186)
 Skin Diseases, Eczematous [MESH:D017443] (3740) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Skin Diseases, Genetic [MESH:D012873] (3481) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Skin Diseases, Infectious [MESH:D012874] (2684) 
 Skin Diseases, Parasitic [MESH:D012876] (2526) 
 Leishmaniasis [MESH:D007896] (2516) 
 Leishmaniasis, Cutaneous [MESH:D016773] (2359)
 Skin Diseases, Vascular [MESH:D017445] (3288) 
 Behcet Syndrome [MESH:D001528] (1784)
 Urticaria [MESH:D014581] (2668) 
 Angioedema [MESH:D000799] (837)
 Skin Diseases, Vesiculobullous [MESH:D012872] (1754) 
 Erythema Multiforme [MESH:D004892] (1185) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
C18. Nutritional and Metabolic Diseases 
C18. Nutritional and Metabolic Diseases
 Metabolic Diseases [MESH:D008659] (9025) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Calcium Metabolism Disorders [MESH:D002128] (3634) 
 Calcinosis [MESH:D002114] (2989)
 Glucose Metabolism Disorders [MESH:D044882] (6122) 
 Diabetes Mellitus [MESH:D003920] (5891) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219) 
 Maturity-Onset Diabetes of the Young, Type 8, with Exocrine Dysfunction [MESH:C565225] (56)
 Hyperinsulinism [MESH:D006946] (3586) 
 Insulin Resistance [MESH:D007333] (3511) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Lipid Metabolism Disorders [MESH:D052439] (3225) 
 Dyslipidemias [MESH:D050171] (2428) 
 Hyperlipidemias [MESH:D006949] (1908) 
 Hypercholesterolemia [MESH:D006937] (1404)
 Hyperlipoproteinemias [MESH:D006951] (903) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Malabsorption Syndromes [MESH:D008286] (1869) 
 Hyperhomocysteinemia [MESH:D020138] (1716)
 Metabolism, Inborn Errors [MESH:D008661] (6028) 
 Butyrylcholinesterase deficiency [MESH:C537417] (176)
 Amino Acid Metabolism, Inborn Errors [MESH:D000592] (2559) 
 Hyperhomocysteinemia [MESH:D020138] (1724)
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Proteostasis Deficiencies [MESH:D057165] (3522) 
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic Lateral Sclerosis, Sporadic [MESH:C566291] (239)
 Nutrition Disorders [MESH:D009748] (4945) 
 Malnutrition [MESH:D044342] (2754) 
 Deficiency Diseases [MESH:D003677] (2742) 
 Avitaminosis [MESH:D001361] (2304) 
 Vitamin B Deficiency [MESH:D014804] (1817) 
 Hyperhomocysteinemia [MESH:D020138] (1716)
 Overnutrition [MESH:D044343] (4463) 
 Obesity [MESH:D009765] (4462)
C19. Endocrine System Diseases 
C19. Endocrine System Diseases
 Endocrine System Diseases [MESH:D004700] (8062) 
 Diabetes Mellitus [MESH:D003920] (6159) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Complications [MESH:D048909] (4129) 
 Diabetic Nephropathies [MESH:D003928] (2301)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219) 
 Maturity-Onset Diabetes of the Young, Type 8, with Exocrine Dysfunction [MESH:C565225] (56)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Thyroid Diseases [MESH:D013959] (2808) 
 Hyperthyroidism [MESH:D006980] (1191)
 Hyperthyroxinemia [MESH:D006981] (659) 
 Hyperthyroxinemia, Familial Dysalbuminemic [MESH:D050010] (478)
 Hypothyroidism [MESH:D007037] (496) 
 Bamforth syndrome [MESH:C537901] (186)
C20. Immune System Diseases 
C20. Immune System Diseases
 Immune System Diseases [MESH:D007154] (7674) 
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770)
 Autoimmune Diseases [MESH:D001327] (5067) 
 Arthritis, Rheumatoid [MESH:D001172] (3601)
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Hepatitis, Autoimmune [MESH:D019693] (1982)
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Hypersensitivity [MESH:D006967] (5873) 
 Hypersensitivity, Delayed [MESH:D006968] (3408)
 Drug Hypersensitivity [MESH:D004342] (4000) 
 Drug Eruptions [MESH:D003875] (2695) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Hypersensitivity, Immediate [MESH:D006969] (4980) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Respiratory Hypersensitivity [MESH:D012130] (4250) 
 Asthma [MESH:D001249] (3914)
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Urticaria [MESH:D014581] (2668) 
 Angioedema [MESH:D000799] (837)
 Immune Complex Diseases [MESH:D007105] (782) 
 Serum Sickness [MESH:D012713] (484)
 Immunologic Deficiency Syndromes [MESH:D007153] (3788) 
 HIV Infections [MESH:D015658] (3402) 
 HIV Seropositivity [MESH:D006679] (480)
 Immunoproliferative Disorders [MESH:D007160] (4761) 
 Lymphoproliferative Disorders [MESH:D008232] (4734) 
 Multiple Myeloma [MESH:D009101] (2767)
 Paraproteinemias [MESH:D010265] (2791) 
 Multiple Myeloma [MESH:D009101] (2765)
C22. Animal Diseases 
C22. Animal Diseases
 Animal Diseases [MESH:D000820] (3656) 
 Disease Models, Animal [MESH:D004195] (2058)
C23. Pathological Conditions, Signs and Symptoms 
C23. Pathological Conditions, Signs and Symptoms
 Pathologic Processes [MESH:D010335] (9863) 
 Death [MESH:D003643] (1328)
 Inflammation [MESH:D007249] (5241)
 Nerve Degeneration [MESH:D009410] (4061)
 Arrhythmias, Cardiac [MESH:D001145] (4658) 
 Tachycardia [MESH:D013610] (3339)
 Fibrosis [MESH:D005355] (3133) 
 Cicatrix [MESH:D002921] (1115) 
 Keloid [MESH:D007627] (1110)
 Postoperative Complications [MESH:D011183] (5311) 
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Signs and Symptoms [MESH:D012816] (10659) 
 Pain [MESH:D010146] (4511)
 Body Temperature Changes [MESH:D001832] (3130) 
 Hypothermia [MESH:D007035] (2075)
 Body Weight [MESH:D001835] (4972) 
 Birth Weight [MESH:D001724] (377)
 Body Weight Changes [MESH:D001836] (3206) 
 Weight Gain [MESH:D015430] (2595)
 Overweight [MESH:D050177] (4455) 
 Obesity [MESH:D009765] (4454)
 Neurologic Manifestations [MESH:D009461] (8702) 
 Pain [MESH:D010146] (3869)
 Paralysis [MESH:D010243] (2298)
 Paresis [MESH:D010291] (419)
 Seizures [MESH:D012640] (4502)
 Dyskinesias [MESH:D020820] (3285) 
 Catalepsy [MESH:D002375] (1429)
 Hyperkinesis [MESH:D006948] (1799)
 Tremor [MESH:D014202] (840)
 Neurobehavioral Manifestations [MESH:D019954] (4706) 
 Memory Disorders [MESH:D008569] (3233)
 Communication Disorders [MESH:D003147] (2918) 
 Learning Disorders [MESH:D007859] (2727)
 Neuromuscular Manifestations [MESH:D020879] (2130) 
 Fasciculation [MESH:D005207] (204)
 Muscle Hypertonia [MESH:D009122] (775) 
 Muscle Spasticity [MESH:D009128] (187)
 Spasm [MESH:D013035] (418) 
 Trismus [MESH:D014313] (221)
 Sensation Disorders [MESH:D012678] (5009) 
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Signs and Symptoms, Digestive [MESH:D012817] (3095) 
 Constipation [MESH:D003248] (506)
 Signs and Symptoms, Respiratory [MESH:D012818] (2724) 
 Apnea [MESH:D001049] (415)
 Urological Manifestations [MESH:D020924] (3532) 
 Proteinuria [MESH:D011507] (3293)
C24. Occupational Diseases 
C24. Occupational Diseases
 Occupational Diseases [MESH:D009784] (3402) 
 Agricultural Workers' Diseases [MESH:D000382] (193)
 Persian Gulf Syndrome [MESH:D018923] (166)
C25. Chemically-Induced Disorders 
C25. Chemically-Induced Disorders
 Drug-Related Side Effects and Adverse Reactions [MESH:D064420] (5839) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Drug Hypersensitivity [MESH:D004342] (4001) 
 Drug Eruptions [MESH:D003875] (2697) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Poisoning [MESH:D011041] (6703) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Neurotoxicity Syndromes [MESH:D020258] (3323)
 Organophosphate Poisoning [MESH:D062025] (497)
 Substance-Related Disorders [MESH:D019966] (6308) 
 Amphetamine-Related Disorders [MESH:D019969] (2858)
 Cocaine-Related Disorders [MESH:D019970] (3054)
 Marijuana Abuse [MESH:D002189] (1132)
 Substance Withdrawal Syndrome [MESH:D013375] (2956)
C26. Wounds and Injuries 
C26. Wounds and Injuries
 Wounds and Injuries [MESH:D014947] (5171) 
 Craniocerebral Trauma [MESH:D006259] (3523) 
 Brain Injuries [MESH:D001930] (3431)
 Spinal Cord Injuries [MESH:D013119] (2688) 
 Spinal Cord Compression [MESH:D013117] (1800)
 Thoracic Injuries [MESH:D013898] (1831) 
 Lung Injury [MESH:D055370] (1814)
 Trauma, Nervous System [MESH:D020196] (3535) 
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
D02. Organic Chemicals 
D02. Organic Chemicals
 Organic Chemicals [MESH:D009930] (75987) 
 Organophosphorus Compounds [MESH:D009943] (2593)