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Jacques Monod
1910-1976
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complete name  Jacques Monod
nobel prize  medicine
award year  1965
together with  François Jacob
together with  André Lwoff
prize share  Prize share: 1/3
rational  The Nobel Prize in Physiology or Medicine 1965 was awarded jointly to François Jacob, André Lwoff and Jacques Monod "for their discoveries concerning genetic control of enzyme and virus synthesis."
biography  Biography
laureate facts  Facts
laureate lecture  Lecture
given name  Jacques
family name  Monod
occupation  physician
occupation  biologist
occupation  biochemist
occupation  geneticist
occupation  French Resistance fighter
field of work  biology
work location  Collège de France, Paris, Sorbonne, France
notable work  Chance and Necessity
description  Jacques Monod was a French biochemist, He won the Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and Andre Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis". Monod (along with François Jacob) became famous for his work on the E. coli lac operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). From their own work and the work of others, he and Jacob came up with a model for how the levels of some proteins in a cell are controlled. In their model, the manufacture of proteins, such as the ones encoded within the lac (lactose) operon, is prevented when a repressor, encoded by a regulatory gene, binds to its operator, a specific site on the DNA next to the genes encoding the proteins. (It is now known that repressor bound to the operator physically blocks RNA polymerase from binding to the promoter, the site where transcription of the adjacent genes begins.) Study of the control of expression of genes in the lac operon provided the first example of a transcriptional regulation system. Monod also suggested the existence of mRNA molecules that link the information encoded in DNA and proteins. He is widely regarded as one of the founders of molecular biology. Monod's interest in the lac operon originated from his doctoral dissertation, for which he studied the growth of bacteria in culture media containing two sugars.
image copyright  Photo from the Nobel Foundation archive.
image citation  The Nobel Prize in Physiology or Medicine 1965. NobelPrize.org. Nobel Media AB 2018. <https://www.nobelprize.org/prizes/medicine/1965/summary/>
date birth  1910
date death  1976
usual name  Jacques Monod