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more general categories information about this item 10. Noble Prize 10. Noble Prize Physiology or Medicine (216) 11. Award Year 11. Award Year 2000s (123) 2000 (13) 12. Winner Type 12. Winner Type Person (904) 13. Gender 13. Gender Male (853) 14. Birth Year 14. Birth Year 1920s (114) 1923 (13) 15. Place of Birth 15. Place of Birth Europe (459) Europe, Nordic countries (56) Sweden (29) Uppsala (3) 16. Death Year 16. Death Year 2010s (99) 2018 (16) 17. Place of Death 17. Place of Death Europe (331) Europe, Nordic countries (49) Sweden (29) Gothenburg (1) 19. Given Name 19. Given Name A-D (182) A (79) 20. Family Name 20. Family Name A-D (195) C (49) 23. Religion 23. Religion z-Missing value reason (465) Source data not available (465) 24. Age at Award Time 24. Age at Award Time 70 - 79 (179) 78 (17) 32. Occupations 32. Occupations Healthcare Practitioners and Technical Occupations (70) Healthcare Diagnosing or Treating Practitioners (69) Physicians (65) 34. Citizens 34. Citizens Europe (450) Europe, Nordic countries (59) Sweden (29) 37. Worked for College or University 37. Worked for College or University Europe (232) Europe, Nordic countries (30) Sweden (16) Gothenburg (1) University of Göttingen (1) 42. Affilliation with College or University 42. Affilliation with College or University Europe (535) Europe, Nordic countries (83) Sweden (35) Lund (6) Lund University (6) Alumni (4) Long-term academic staff (3) 44. Memberships 44. Memberships A-D (656) A (635) Academia Europaea (55) R-T (460) R (448) Royal Swedish Academy of Sciences (111) 45. Other Awards 45. Other Awards A-B (362) B (132) Björkén Prize (8) Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (10) E-F (439) F (394) Feltrinelli Prize (5) G-H (389) G (254) Gairdner Foundation International Award (89) Golden Kraepelin Medal (1) I-J (268) J (208) Japan Prize (8) M-N (333) N (205) Nordic Research Prize (1) Q-Z (398) R (196) Robert J. and Claire Pasarow Foundation Award for Distinguished Contributions to Neuropsychiatric Research (3) W (157) Wolf Prize in Medicine (19) complete name: Arvid Carlsson nobel prize: medicine award year: 2000 together with: Eric Kandel together with: Paul Greengard prize share: Prize share: 1/3 rational: The Nobel Prize in Physiology or Medicine 2000 was awarded jointly to Arvid Carlsson, Paul Greengard and Eric R. Kandel "for their discoveries concerning signal transduction in the nervous system." biography: Biography laureate facts: Facts laureate lecture: Lecture given name: Arvid family name: Carlsson occupation: physician occupation: pharmacist occupation: university teacher occupation: pharmacologist occupation: neuroscientist field of work: chemistry field of work: molecular biology work location: University of Gothenburg, Gothenburg, Gothenburg Municipality, Sweden description: Arvid Carlsson is a Swedish neuropharmacologist who is best known for his work with the neurotransmitter dopamine and its effects in Parkinson's disease. For his work on dopamine, Carlsson was awarded the Nobel Prize in Physiology or Medicine in 2000, along with co-recipients Eric Kandel and Paul Greengard. Carlsson was born in Uppsala, Sweden, son of Gottfrid Carlsson, historian and later professor of history at the Lund University, where he began his medical education in 1941. In 1944 he was participating in the task of examining prisoners of Nazi concentration camps, whom Folke Bernadotte, a member of the royal Swedish family, had managed to bring to Sweden. Although Sweden was neutral during World War II, Carlsson's education was interrupted by several years of service in the Swedish Armed Forces. In 1951, he received his M.L. degree and his M.D. He then became a professor at the University of Lund. In 1959 he became a professor at the University of Gothenburg. In 1957 Kathleen Montagu succeeded in demonstrating the presence of dopamine in the human brain; later that same year Carlsson also demonstrated that dopamine was a neurotransmitter in the brain and not just a precursor for norepinephrine. Carlsson went on to developed a method for measuring the amount of dopamine in brain tissues. He found that dopamine levels in the basal ganglia, a brain area important for movement, were particularly high. He then showed that giving animals the drug reserpine caused a decrease in dopamine levels and a loss of movement control. These effects were similar to the symptoms of Parkinson's disease. By administering to these animals L-Dopa, which is the precursor of dopamine, he could alleviate the symptoms. These findings led other doctors to try using L-Dopa on patients with Parkinson's disease, and found it to alleviate some of the symptoms in the early stages of the disease. L-Dopa is still the basis for most commonly used means of treating Parkinson's disease. While working at Astra AB, Carlsson and his colleagues were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Zimelidine preceded both Fluoxetine (Prozac) and Fluvoxamine as the first SSRI, but was later withdrawn from the market due to rare cases of Guillain-Barré syndrome. Carlsson is opposed to the fluoridation of drinking water, and lobbied in Sweden to make water fluoridation illegal. Still an active researcher and speaker at over 90 years of age, Carlsson, together with his daughter Maria, is working on OSU6162, a dopamine stabilizer alleviating symtoms of post-stroke fatigue. image copyright: Photo from the Nobel Foundation archive. image citation: The Nobel Prize in Physiology or Medicine 2000. NobelPrize.org. Nobel Media AB 2018. <https://www.nobelprize.org/prizes/medicine/2000/summary/> date birth: 1923 date death: 2018 usual name: Arvid Carlsson
