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more general categories information about this item 10. Biology and Chemistry 10. Biology and Chemistry Biology and Chemistry (144) Biochemistry (39) description: International Union of Basic and Clinical Pharmacology Ligands and Targets (IUPHAR) data is about a substance that forms a bond with a biomolecule to serve a biological purpose. In protein-ligand binding, ligand usually is a signal-triggering molecule, binding to a site on a target protein. In DNA-ligand binding studies, ligand is usually a small molecule, ion or protein that binds to the DNA double helix. AFDSI imports ligand and associated target data from IUPHAR. complete name: International Union of Basic and Clinical Pharmacology Ligands and Targets