Item 5 of 881 (back to results) previous next   mitragynine C001801               MeSH Unique Identifier: C001801 Scope Notes: Acts on mu- and delta-opioid subtype receptors Chemical – Gene Interaction Note 1: Mitragynine results in increased activity of CYP1A2 protein Note 2: Mitragynine results in increased expression of CYP1A2 mRNA Click here for more information

Current search: C18. Nutritional and Metabolic Diseases: Metabolic Diseases [MESH:D008659] > Porphyrias [MESH:D011164] > Porphyrias, Hepatic [MESH:D017094] × Select any link to see items in a related category. more general categories    information about this item 1. Human Genes  1. Human Genes  Cytochrome P450s [HGNC:CYP] (1673)   cytochrome P450, family 01, subfamily A, polypeptide 02 [HGNC:CYP1A2] (466)  cytochrome P450, family 02, subfamily D, polypeptide 06 [HGNC:CYP2D6] (200)  cytochrome P450, family 03, subfamily A, polypeptide 04 [HGNC:CYP3A4] (612) 2. Interaction: Human Genes and Chemicals  2. Interaction: Human Genes and Chemicals  Increases (5571)   activity (2865)  expression (3238) C02. Virus Diseases  C02. Virus Diseases  Virus Diseases [MESH:D014777] (4544)   Hepatitis, Viral, Human [MESH:D006525] (1766)   Hepatitis C [MESH:D006526] (1627)  RNA Virus Infections [MESH:D012327] (4215)   Flaviviridae Infections [MESH:D018178] (1656)   Hepatitis C [MESH:D006526] (1627) C04. Neoplasms  C04. Neoplasms  Neoplasms [MESH:D009369] (10293)   Cysts [MESH:D003560] (2625)   Ovarian Cysts [MESH:D010048] (2534)  Neoplasms by Histologic Type [MESH:D009370] (8793)   Leukemia [MESH:D007938] (4576)   Leukemia, Lymphoid [MESH:D007945] (3047)   Leukemia, B-Cell [MESH:D015448] (2564)   Leukemia, Lymphocytic, Chronic, B-Cell [MESH:D015451] (2562)  Lymphoma [MESH:D008223] (3686)   Lymphoma, Non-Hodgkin [MESH:D008228] (3337)   Lymphoma, B-Cell [MESH:D016393] (2624)  Neoplasms, Connective and Soft Tissue [MESH:D018204] (4742)   Neoplasms, Connective Tissue [MESH:D009372] (3626)   Neoplasms, Bone Tissue [MESH:D018213] (2217)   Osteosarcoma [MESH:D012516] (2175)  Neoplasms, Muscle Tissue [MESH:D009379] (1965)   Leiomyosarcoma [MESH:D007890] (977)  Sarcoma [MESH:D012509] (4246)   Leiomyosarcoma [MESH:D007890] (977)  Osteosarcoma [MESH:D012516] (2175)  Neoplasms, Germ Cell and Embryonal [MESH:D009373] (5126)   Neuroectodermal Tumors [MESH:D017599] (5066)   Neoplasms, Neuroepithelial [MESH:D018302] (4487)   Glioma [MESH:D005910] (4261)  Neuroendocrine Tumors [MESH:D018358] (3633)   Melanoma [MESH:D008545] (3508)  Neoplasms, Glandular and Epithelial [MESH:D009375] (7760)   Adenoma [MESH:D000236] (4051)   Adenomatous Polyps [MESH:D018256] (1571)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Carcinoma [MESH:D002277] (7263)   Carcinoma in Situ [MESH:D002278] (2111)  Carcinoma, Transitional Cell [MESH:D002295] (2662)  Adenocarcinoma [MESH:D000230] (6565)   Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Carcinoma, Hepatocellular [MESH:D006528] (5375)  Carcinoma, Renal Cell [MESH:D002292] (2975)  Cholangiocarcinoma [MESH:D018281] (2398)  Carcinoma, Ductal [MESH:D044584] (1786)   Carcinoma, Ductal, Breast [MESH:D018270] (1112)  Carcinoma, Squamous Cell [MESH:D002294] (4294)   Carcinoma, squamous cell of head and neck [MESH:C535575] (1543)  Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Neoplasms, Ductal, Lobular, and Medullary [MESH:D018299] (1831)   Carcinoma, Ductal [MESH:D044584] (1786)   Carcinoma, Ductal, Breast [MESH:D018270] (1112)  Neoplasms, Neuroepithelial [MESH:D018302] (4487)   Glioma [MESH:D005910] (4261)  Neoplasms, Squamous Cell [MESH:D018307] (4457)   Papilloma [MESH:D010212] (2243)  Carcinoma, Squamous Cell [MESH:D002294] (4294)   Carcinoma, squamous cell of head and neck [MESH:C535575] (1543)  Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Neoplasms, Nerve Tissue [MESH:D009380] (5201)   Neuroectodermal Tumors [MESH:D017599] (5059)   Neoplasms, Neuroepithelial [MESH:D018302] (4487)   Glioma [MESH:D005910] (4261)  Neuroendocrine Tumors [MESH:D018358] (3625)   Melanoma [MESH:D008545] (3508)  Nevi and Melanomas [MESH:D018326] (3572)   Melanoma [MESH:D008545] (3508)  Neoplasms by Site [MESH:D009371] (9169)   Bone Neoplasms [MESH:D001859] (1334)  Skin Neoplasms [MESH:D012878] (2992)  Breast Neoplasms [MESH:D001943] (6077)   Carcinoma, Ductal, Breast [MESH:D018270] (1112)  Digestive System Neoplasms [MESH:D004067] (7487)   Pancreatic Neoplasms [MESH:D010190] (3820)  Gastrointestinal Neoplasms [MESH:D005770] (6452)   Stomach Neoplasms [MESH:D013274] (4942)  Esophageal Neoplasms [MESH:D004938] (3737)   Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Intestinal Neoplasms [MESH:D007414] (5358)   Colorectal Neoplasms [MESH:D015179] (5294)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Colonic Neoplasms [MESH:D003110] (4405)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Liver Neoplasms [MESH:D008113] (6048)   Carcinoma, Hepatocellular [MESH:D006528] (5375)  Liver Neoplasms, Experimental [MESH:D008114] (2837)  Endocrine Gland Neoplasms [MESH:D004701] (4925)   Pancreatic Neoplasms [MESH:D010190] (3820)  Thyroid Neoplasms [MESH:D013964] (2040)  Head and Neck Neoplasms [MESH:D006258] (4612)   Carcinoma, squamous cell of head and neck [MESH:C535575] (1543)  Thyroid Neoplasms [MESH:D013964] (2040)  Esophageal Neoplasms [MESH:D004938] (3737)   Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Mouth Neoplasms [MESH:D009062] (2263)   Leukoplakia, Oral [MESH:D007972] (921)  Tongue Neoplasms [MESH:D014062] (1518)  Thoracic Neoplasms [MESH:D013899] (6032)   Respiratory Tract Neoplasms [MESH:D012142] (6020)   Lung Neoplasms [MESH:D008175] (6015)  Urogenital Neoplasms [MESH:D014565] (7002)   Genital Neoplasms, Male [MESH:D005834] (6224)   Prostatic Neoplasms [MESH:D011471] (6135)  Urologic Neoplasms [MESH:D014571] (5315)   Urinary Bladder Neoplasms [MESH:D001749] (4079)  Kidney Neoplasms [MESH:D007680] (3966)   Carcinoma, Renal Cell [MESH:D002292] (2975)  Neoplasms, Experimental [MESH:D009374] (5218)   Liver Neoplasms, Experimental [MESH:D008114] (2837)  Neoplastic Processes [MESH:D009385] (5317)   Neoplasm Metastasis [MESH:D009362] (4441)  Neoplasm Recurrence, Local [MESH:D009364] (1949)  Neoplastic Syndromes, Hereditary [MESH:D009386] (2578)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Precancerous Conditions [MESH:D011230] (2858)   Leukoplakia [MESH:D007971] (922)   Leukoplakia, Oral [MESH:D007972] (921) C05. Musculoskeletal Diseases  C05. Musculoskeletal Diseases  Musculoskeletal Diseases [MESH:D009140] (8705)   Bone Diseases [MESH:D001847] (5801)   Bone Neoplasms [MESH:D001859] (1334)  Joint Diseases [MESH:D007592] (4657)   Arthritis [MESH:D001168] (4416)   Arthritis, Rheumatoid [MESH:D001172] (3603)  Muscular Diseases [MESH:D009135] (4071)   Muscle Rigidity [MESH:D009127] (617)  Rheumatic Diseases [MESH:D012216] (4032)   Arthritis, Rheumatoid [MESH:D001172] (3603) C06. Digestive System Diseases  C06. Digestive System Diseases  Digestive System Diseases [MESH:D004066] (9461)   Digestive System Abnormalities [MESH:D004065] (2127)   Barrett Esophagus [MESH:D001471] (1930)  Digestive System Neoplasms [MESH:D004067] (7493)   Pancreatic Neoplasms [MESH:D010190] (3820)  Gastrointestinal Neoplasms [MESH:D005770] (6460)   Stomach Neoplasms [MESH:D013274] (4942)  Esophageal Neoplasms [MESH:D004938] (3737)   Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Intestinal Neoplasms [MESH:D007414] (5359)   Colorectal Neoplasms [MESH:D015179] (5294)   Colonic Neoplasms [MESH:D003110] (4405)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Liver Neoplasms [MESH:D008113] (6048)   Carcinoma, Hepatocellular [MESH:D006528] (5375)  Liver Neoplasms, Experimental [MESH:D008114] (2837)  Gastrointestinal Diseases [MESH:D005767] (7443)   Esophageal Diseases [MESH:D004935] (4255)   Barrett Esophagus [MESH:D001471] (1930)  Deglutition Disorders [MESH:D003680] (1538)   Esophageal Motility Disorders [MESH:D015154] (1489)   Gastroesophageal Reflux [MESH:D005764] (1465)  Esophageal Neoplasms [MESH:D004938] (3737)   Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Gastroenteritis [MESH:D005759] (4066)   Colitis [MESH:D003092] (3199)  Inflammatory Bowel Diseases [MESH:D015212] (3492)  Gastrointestinal Neoplasms [MESH:D005770] (6460)   Stomach Neoplasms [MESH:D013274] (4942)  Esophageal Neoplasms [MESH:D004938] (3737)   Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)  Adenocarcinoma Of Esophagus [MESH:C562730] (1530)  Intestinal Neoplasms [MESH:D007414] (5359)   Colorectal Neoplasms [MESH:D015179] (5294)   Colonic Neoplasms [MESH:D003110] (4405)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Intestinal Diseases [MESH:D007410] (6206)   Inflammatory Bowel Diseases [MESH:D015212] (3492)  Colonic Diseases [MESH:D003108] (5564)   Colitis [MESH:D003092] (3199)  Colorectal Neoplasms [MESH:D015179] (5282)   Colonic Neoplasms [MESH:D003110] (4405)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Duodenal Diseases [MESH:D004378] (1982)   Peptic Ulcer [MESH:D010437] (1969)   Duodenal Ulcer [MESH:D004381] (1549)  Intestinal Neoplasms [MESH:D007414] (5359)   Colorectal Neoplasms [MESH:D015179] (5294)   Colonic Neoplasms [MESH:D003110] (4405)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Intestinal Polyposis [MESH:D044483] (1610)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Rectal Diseases [MESH:D012002] (4596)   Colorectal Neoplasms [MESH:D015179] (4534)  Peptic Ulcer [MESH:D010437] (3172)   Duodenal Ulcer [MESH:D004381] (1549)  Stomach Ulcer [MESH:D013276] (2915)  Stomach Diseases [MESH:D013272] (5325)   Stomach Neoplasms [MESH:D013274] (4942)  Peptic Ulcer [MESH:D010437] (2994)   Stomach Ulcer [MESH:D013276] (2915)  Liver Diseases [MESH:D008107] (8167)   Drug-Induced Liver Injury [MESH:D056486] (4936)  Hepatomegaly [MESH:D006529] (1169)  Hepatitis [MESH:D006505] (3883)   Hepatitis, Viral, Human [MESH:D006525] (1766)   Hepatitis C [MESH:D006526] (1627)  Liver Cirrhosis [MESH:D008103] (5542)   Liver Cirrhosis, Experimental [MESH:D008106] (4589)  Liver Neoplasms [MESH:D008113] (6048)   Carcinoma, Hepatocellular [MESH:D006528] (5375)  Liver Neoplasms, Experimental [MESH:D008114] (2837)  Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Pancreatic Diseases [MESH:D010182] (4453)   Pancreatic Neoplasms [MESH:D010190] (3820)  Pancreatitis [MESH:D010195] (1924) C07. Stomatognathic Diseases  C07. Stomatognathic Diseases  Stomatognathic Diseases [MESH:D009057] (5348)   Mouth Diseases [MESH:D009059] (4783)   Oral Submucous Fibrosis [MESH:D009914] (2432)  Mouth Neoplasms [MESH:D009062] (2263)   Leukoplakia, Oral [MESH:D007972] (921)  Tongue Neoplasms [MESH:D014062] (1518)  Tongue Diseases [MESH:D014060] (1544)   Tongue Neoplasms [MESH:D014062] (1518) C08. Respiratory Tract Diseases  C08. Respiratory Tract Diseases  Respiratory Tract Diseases [MESH:D012140] (7881)   Bronchial Diseases [MESH:D001982] (4382)   Bronchial Hyperreactivity [MESH:D016535] (1357)  Asthma [MESH:D001249] (4098)   Asthma, Aspirin-Induced [MESH:D055963] (1055)  Lung Diseases [MESH:D008171] (7249)   Lung Neoplasms [MESH:D008175] (6012)  Lung Diseases, Obstructive [MESH:D008173] (4697)   Pulmonary Disease, Chronic Obstructive [MESH:D029424] (3564)  Respiratory Hypersensitivity [MESH:D012130] (4401)   Asthma [MESH:D001249] (4098)   Asthma, Aspirin-Induced [MESH:D055963] (1055)  Respiratory Tract Neoplasms [MESH:D012142] (6053)   Lung Neoplasms [MESH:D008175] (6013) C10. Nervous System Diseases  C10. Nervous System Diseases  Z. Exceptions (4027)   Not Fully Specified [NFS] (4027)  Nervous System Diseases [MESH:D009422] (13325)   Central Nervous System Diseases [MESH:D002493] (9745)   Brain Diseases [MESH:D001927] (9294)   Brain Injuries [MESH:D001930] (3429)  Basal Ganglia Diseases [MESH:D001480] (4268)   Parkinsonian Disorders [MESH:D020734] (4009)   Parkinson Disease [MESH:D010300] (3595)  Cerebrovascular Disorders [MESH:D002561] (5542)   Brain Ischemia [MESH:D002545] (4873)  Stroke [MESH:D020521] (3702)  Dementia [MESH:D003704] (4498)   Alzheimer Disease [MESH:D000544] (4275)  Epilepsy [MESH:D004827] (6274)   Seizures [MESH:D012640] (4502)  Status Epilepticus [MESH:D013226] (4014)  Epilepsy, Generalized [MESH:D004829] (1431)   Epilepsy, Tonic-Clonic [MESH:D004830] (1042)  Movement Disorders [MESH:D009069] (4823)   Parkinsonian Disorders [MESH:D020734] (4009)   Parkinson Disease [MESH:D010300] (3595)  Spinal Cord Diseases [MESH:D013118] (4376)   Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)  Nervous System Malformations [MESH:D009421] (3354)   Neural Tube Defects [MESH:D009436] (2143)  Neurodegenerative Diseases [MESH:D019636] (6613)   Parkinson Disease [MESH:D010300] (3595)  Motor Neuron Disease [MESH:D016472] (3670)   Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)  Tauopathies [MESH:D024801] (4289)   Alzheimer Disease [MESH:D000544] (4275)  TDP-43 Proteinopathies [MESH:D057177] (3337)   Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)  Neurologic Manifestations [MESH:D009461] (8964)   Neurogenic Inflammation [MESH:D020078] (2246)  Seizures [MESH:D012640] (4514)  Dyskinesias [MESH:D020820] (3365)   Dystonia [MESH:D004421] (848)  Tremor [MESH:D014202] (840)  Neurobehavioral Manifestations [MESH:D019954] (5230)   Consciousness Disorders [MESH:D003244] (680)   Unconsciousness [MESH:D014474] (660)   Coma [MESH:D003128] (524)  Neuromuscular Manifestations [MESH:D020879] (2130)   Muscle Hypertonia [MESH:D009122] (775)   Muscle Rigidity [MESH:D009127] (617)  Sensation Disorders [MESH:D012678] (5011)   Somatosensory Disorders [MESH:D020886] (4000)   Hyperalgesia [MESH:D006930] (3929)  Neuromuscular Diseases [MESH:D009468] (7336)   Peripheral Nervous System Diseases [MESH:D010523] (6151)  Motor Neuron Disease [MESH:D016472] (3670)   Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)  Neurotoxicity Syndromes [MESH:D020258] (4570)   Heavy Metal Poisoning, Nervous System [MESH:D020260] (2912)   Manganese Poisoning [MESH:D020149] (2214)  Sleep Disorders [MESH:D012893] (2050)   Dyssomnias [MESH:D020920] (1417)   Sleep Deprivation [MESH:D012892] (233)  Trauma, Nervous System [MESH:D020196] (3997)   Craniocerebral Trauma [MESH:D006259] (3507)   Brain Injuries [MESH:D001930] (3431) C11. Eye Diseases  C11. Eye Diseases  Eye Diseases [MESH:D005128] (6245)   Ocular Hypertension [MESH:D009798] (1630)   Glaucoma [MESH:D005901] (1458)   Glaucoma, Open-Angle [MESH:D005902] (1281) C12. Male Urogenital Diseases  C12. Male Urogenital Diseases  Male Urogenital Diseases [MESH:D052801] (8891)   Genital Diseases, Male [MESH:D005832] (6794)   Genital Neoplasms, Male [MESH:D005834] (6224)   Prostatic Neoplasms [MESH:D011471] (6135)  Prostatic Diseases [MESH:D011469] (6204)   Prostatic Neoplasms [MESH:D011471] (6135)  Urogenital Neoplasms [MESH:D014565] (6932)   Genital Neoplasms, Male [MESH:D005834] (6224)   Prostatic Neoplasms [MESH:D011471] (6135)  Urologic Neoplasms [MESH:D014571] (5315)   Urinary Bladder Neoplasms [MESH:D001749] (4079)  Kidney Neoplasms [MESH:D007680] (3966)   Carcinoma, Renal Cell [MESH:D002292] (2975)  Urologic Diseases [MESH:D014570] (7792)   Kidney Diseases [MESH:D007674] (7242)   Hydronephrosis [MESH:D006869] (956)  Kidney Neoplasms [MESH:D007680] (3966)   Carcinoma, Renal Cell [MESH:D002292] (2975)  Nephritis [MESH:D009393] (4236)   Nephritis, Interstitial [MESH:D009395] (1927)  Renal Insufficiency [MESH:D051437] (4951)   Acute Kidney Injury [MESH:D058186] (4142)  Renal Insufficiency, Chronic [MESH:D051436] (2931)   Kidney Failure, Chronic [MESH:D007676] (2930)  Urethral Diseases [MESH:D014522] (955)   Urethral Obstruction [MESH:D014524] (937)   Urinary Bladder Neck Obstruction [MESH:D001748] (924)  Urinary Bladder Diseases [MESH:D001745] (4374)   Urinary Bladder Neck Obstruction [MESH:D001748] (924)  Urinary Bladder Neoplasms [MESH:D001749] (4079)  Urination Disorders [MESH:D014555] (3598)   Proteinuria [MESH:D011507] (3293)   Albuminuria [MESH:D000419] (2394) C13. Female Urogenital Diseases and Pregnancy Complications  C13. Female Urogenital Diseases and Pregnancy Complications  Female Urogenital Diseases [MESH:D052776] (8724)   Genital Diseases, Female [MESH:D005831] (5563)   Adnexal Diseases [MESH:D000291] (4273)   Ovarian Diseases [MESH:D010049] (4255)   Ovarian Cysts [MESH:D010048] (2534)  Urogenital Neoplasms [MESH:D014565] (5792)   Urologic Neoplasms [MESH:D014571] (5315)   Urinary Bladder Neoplasms [MESH:D001749] (4079)  Kidney Neoplasms [MESH:D007680] (3966)   Carcinoma, Renal Cell [MESH:D002292] (2975)  Urologic Diseases [MESH:D014570] (7793)   Kidney Diseases [MESH:D007674] (7242)   Hydronephrosis [MESH:D006869] (956)  Kidney Neoplasms [MESH:D007680] (3966)   Carcinoma, Renal Cell [MESH:D002292] (2975)  Nephritis [MESH:D009393] (4236)   Nephritis, Interstitial [MESH:D009395] (1927)  Renal Insufficiency [MESH:D051437] (4951)   Acute Kidney Injury [MESH:D058186] (4142)  Renal Insufficiency, Chronic [MESH:D051436] (2931)   Kidney Failure, Chronic [MESH:D007676] (2930)  Urethral Diseases [MESH:D014522] (955)   Urethral Obstruction [MESH:D014524] (937)   Urinary Bladder Neck Obstruction [MESH:D001748] (924)  Urinary Bladder Diseases [MESH:D001745] (4375)   Urinary Bladder Neck Obstruction [MESH:D001748] (924)  Urinary Bladder Neoplasms [MESH:D001749] (4079)  Urination Disorders [MESH:D014555] (3598)   Proteinuria [MESH:D011507] (3293)   Albuminuria [MESH:D000419] (2394)  Pregnancy Complications [MESH:D011248] (4768)   Prenatal Injuries [MESH:D049188] (1314)   Prenatal Exposure Delayed Effects [MESH:D011297] (870) C14. Cardiovascular Diseases  C14. Cardiovascular Diseases  Z. Exceptions (2667)   Not Fully Specified [NFS] (2667)  Cardiovascular Diseases [MESH:D002318] (10123)   Heart Diseases [MESH:D006331] (8614)   Cardiomyopathies [MESH:D009202] (5331)  Heart Failure [MESH:D006333] (4058)  Pericardial Effusion [MESH:D010490] (1015)  Arrhythmias, Cardiac [MESH:D001145] (4679)   Bradycardia [MESH:D001919] (1899)  Tachycardia [MESH:D013610] (3339)   Tachycardia, Ventricular [MESH:D017180] (1386)   Torsades de Pointes [MESH:D016171] (880)  Myocardial Ischemia [MESH:D017202] (5787)   Coronary Disease [MESH:D003327] (3439)   Coronary Artery Disease [MESH:D003324] (2685)  Vascular Diseases [MESH:D014652] (8691)   Hyperemia [MESH:D006940] (2372)  Hypertension [MESH:D006973] (5655)  Reperfusion Injury [MESH:D015427] (4968)  Aneurysm [MESH:D000783] (1886)   Aortic Aneurysm [MESH:D001014] (1721)   Aortic Aneurysm, Abdominal [MESH:D017544] (1519)  Aortic Diseases [MESH:D001018] (1737)   Aortic Aneurysm [MESH:D001014] (1721)   Aortic Aneurysm, Abdominal [MESH:D017544] (1519)  Arterial Occlusive Diseases [MESH:D001157] (4520)   Arteriosclerosis [MESH:D001161] (4466)   Atherosclerosis [MESH:D050197] (4188)  Coronary Artery Disease [MESH:D003324] (2685)  Cerebrovascular Disorders [MESH:D002561] (5541)   Brain Ischemia [MESH:D002545] (4873)  Stroke [MESH:D020521] (3702)  Embolism and Thrombosis [MESH:D016769] (3374)   Thrombosis [MESH:D013927] (3101)  Myocardial Ischemia [MESH:D017202] (5791)   Coronary Disease [MESH:D003327] (3439)   Coronary Artery Disease [MESH:D003324] (2685) C15. Hemic and Lymphatic Diseases  C15. Hemic and Lymphatic Diseases  Hematologic Diseases [MESH:D006402] (6174)   Methemoglobinemia [MESH:D008708] (850)  Lymphatic Diseases [MESH:D008206] (5167)   Splenic Diseases [MESH:D013158] (1323)  Lymphoproliferative Disorders [MESH:D008232] (4638)   Leukemia, Lymphoid [MESH:D007945] (3047)   Leukemia, B-Cell [MESH:D015448] (2564)   Leukemia, Lymphocytic, Chronic, B-Cell [MESH:D015451] (2562)  Lymphoma [MESH:D008223] (3684)   Lymphoma, Non-Hodgkin [MESH:D008228] (3330)   Lymphoma, B-Cell [MESH:D016393] (2624) C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities  C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities  Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152)   Congenital Abnormalities [MESH:D000013] (8109)   Nervous System Malformations [MESH:D009421] (3354)   Neural Tube Defects [MESH:D009436] (2143)  Genetic Diseases, Inborn [MESH:D030342] (9766)   Metabolism, Inborn Errors [MESH:D008661] (6032)   Drug Metabolism, Poor, CYP2D6-Related [MESH:C563835] (220)  Porphyrias [MESH:D011164] (917)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Neoplastic Syndromes, Hereditary [MESH:D009386] (2578)   Adenomatous Polyposis Coli [MESH:D011125] (1565)  Skin Diseases, Genetic [MESH:D012873] (3456)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Infant, Newborn, Diseases [MESH:D007232] (3064)   Asphyxia Neonatorum [MESH:D001238] (1648) C17. Skin and Connective Tissue Diseases  C17. Skin and Connective Tissue Diseases  Connective Tissue Diseases [MESH:D003240] (4490)   Lupus Erythematosus, Systemic [MESH:D008180] (2317)  Rheumatic Diseases [MESH:D012216] (3619)   Arthritis, Rheumatoid [MESH:D001172] (3603)  Skin Diseases [MESH:D012871] (8774)   Skin Neoplasms [MESH:D012878] (2991)  Breast Diseases [MESH:D001941] (6148)   Breast Neoplasms [MESH:D001943] (6077)   Carcinoma, Ductal, Breast [MESH:D018270] (1112)  Skin Diseases, Genetic [MESH:D012873] (3481)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Skin Diseases, Metabolic [MESH:D012875] (1574)   Porphyrias [MESH:D011164] (917)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766) C18. Nutritional and Metabolic Diseases  C18. Nutritional and Metabolic Diseases  Metabolic Diseases [MESH:D008659] (9025)   Glucose Metabolism Disorders [MESH:D044882] (6122)   Hyperglycemia [MESH:D006943] (1858)  Diabetes Mellitus [MESH:D003920] (5891)   Diabetes Mellitus, Experimental [MESH:D003921] (4771)  Diabetes Mellitus, Type 2 [MESH:D003924] (4219)  Metabolism, Inborn Errors [MESH:D008661] (6028)   Drug Metabolism, Poor, CYP2D6-Related [MESH:C563835] (220)  Porphyrias [MESH:D011164] (917)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Porphyrias [MESH:D011164] (917)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Proteostasis Deficiencies [MESH:D057165] (3522)   TDP-43 Proteinopathies [MESH:D057177] (3337)   Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)  Skin Diseases, Metabolic [MESH:D012875] (1574)   Porphyrias [MESH:D011164] (917)   Porphyrias, Hepatic [MESH:D017094] (881)   Porphyria Cutanea Tarda [MESH:D017119] (766)  Nutrition Disorders [MESH:D009748] (4945)   Overnutrition [MESH:D044343] (4463)   Obesity [MESH:D009765] (4462) C19. Endocrine System Diseases  C19. Endocrine System Diseases  Endocrine System Diseases [MESH:D004700] (8062)   Diabetes Mellitus [MESH:D003920] (6159)   Diabetes Mellitus, Experimental [MESH:D003921] (4771)  Diabetes Mellitus, Type 2 [MESH:D003924] (4219)  Endocrine Gland Neoplasms [MESH:D004701] (4925)   Pancreatic Neoplasms [MESH:D010190] (3820)  Thyroid Neoplasms [MESH:D013964] (2040)  Gonadal Disorders [MESH:D006058] (5088)   Puberty, Precocious [MESH:D011629] (1147)  Ovarian Diseases [MESH:D010049] (4253)   Ovarian Cysts [MESH:D010048] (2534)  Thyroid Diseases [MESH:D013959] (2808)   Thyroid Neoplasms [MESH:D013964] (2040) C20. Immune System Diseases  C20. Immune System Diseases  Immune System Diseases [MESH:D007154] (7674)   Autoimmune Diseases [MESH:D001327] (5067)   Arthritis, Rheumatoid [MESH:D001172] (3601)  Lupus Erythematosus, Systemic [MESH:D008180] (2317)  Hypersensitivity [MESH:D006967] (5873)   Drug Hypersensitivity [MESH:D004342] (4000)   Asthma, Aspirin-Induced [MESH:D055963] (1055)  Hypersensitivity, Immediate [MESH:D006969] (4980)   Asthma, Aspirin-Induced [MESH:D055963] (1055)  Immunoproliferative Disorders [MESH:D007160] (4761)   Lymphoproliferative Disorders [MESH:D008232] (4734)   Leukemia, Lymphoid [MESH:D007945] (3047)   Leukemia, B-Cell [MESH:D015448] (2564)   Leukemia, Lymphocytic, Chronic, B-Cell [MESH:D015451] (2562)  Lymphoma [MESH:D008223] (3684)   Lymphoma, Non-Hodgkin [MESH:D008228] (3330)   Lymphoma, B-Cell [MESH:D016393] (2624) C23. Pathological Conditions, Signs and Symptoms  C23. Pathological Conditions, Signs and Symptoms  Pathological Conditions, Anatomical [MESH:D020763] (6074)   Atrophy [MESH:D001284] (2603)  Hypertrophy [MESH:D006984] (4476)   Hepatomegaly [MESH:D006529] (1169)  Splenomegaly [MESH:D013163] (1258)  Leukoplakia [MESH:D007971] (922)   Leukoplakia, Oral [MESH:D007972] (921)  Polyps [MESH:D011127] (1633)   Intestinal Polyps [MESH:D007417] (1592)  Pathologic Processes [MESH:D010335] (9863)   Fibrosis [MESH:D005355] (3133)  Growth Disorders [MESH:D006130] (2438)  Hyperplasia [MESH:D006965] (2463)  Arrhythmias, Cardiac [MESH:D001145] (4658)   Bradycardia [MESH:D001919] (1899)  Tachycardia [MESH:D013610] (3339)   Tachycardia, Ventricular [MESH:D017180] (1386)   Torsades de Pointes [MESH:D016171] (880)  Inflammation [MESH:D007249] (5241)   Neurogenic Inflammation [MESH:D020078] (2246)  Neoplastic Processes [MESH:D009385] (5317)   Neoplasm Metastasis [MESH:D009362] (4441)  Neoplasm Recurrence, Local [MESH:D009364] (1949)  Postoperative Complications [MESH:D011183] (5311)   Reperfusion Injury [MESH:D015427] (4968)  Signs and Symptoms [MESH:D012816] (10659)   Edema [MESH:D004487] (3726)  Flushing [MESH:D005483] (506)  Body Weight [MESH:D001835] (4972)   Body Weight Changes [MESH:D001836] (3206)   Weight Gain [MESH:D015430] (2595)  Weight Loss [MESH:D015431] (2512)   Emaciation [MESH:D004614] (2285)   Cachexia [MESH:D002100] (2283)  Overweight [MESH:D050177] (4455)   Obesity [MESH:D009765] (4454)  Neurologic Manifestations [MESH:D009461] (8702)   Seizures [MESH:D012640] (4502)  Dyskinesias [MESH:D020820] (3285)   Dystonia [MESH:D004421] (848)  Tremor [MESH:D014202] (840)  Neurobehavioral Manifestations [MESH:D019954] (4706)   Consciousness Disorders [MESH:D003244] (677)   Unconsciousness [MESH:D014474] (657)   Coma [MESH:D003128] (492)  Neuromuscular Manifestations [MESH:D020879] (2130)   Muscle Hypertonia [MESH:D009122] (775)   Muscle Rigidity [MESH:D009127] (617)  Sensation Disorders [MESH:D012678] (5009)   Somatosensory Disorders [MESH:D020886] (4000)   Hyperalgesia [MESH:D006930] (3929)  Sleep Disorders [MESH:D012893] (1301)   Sleep Deprivation [MESH:D012892] (233)  Urological Manifestations [MESH:D020924] (3532)   Proteinuria [MESH:D011507] (3293)   Albuminuria [MESH:D000419] (2394) C24. Occupational Diseases  C24. Occupational Diseases  Occupational Diseases [MESH:D009784] (3402)  Z. Exceptions (1530)   Not Fully Specified [NFS] (1530) C25. Chemically-Induced Disorders  C25. Chemically-Induced Disorders  Drug-Related Side Effects and Adverse Reactions [MESH:D064420] (5839)   Drug-Induced Liver Injury [MESH:D056486] (4936)  Drug Hypersensitivity [MESH:D004342] (4001)   Asthma, Aspirin-Induced [MESH:D055963] (1055)  Poisoning [MESH:D011041] (6703)   Drug-Induced Liver Injury [MESH:D056486] (4936)  Manganese Poisoning [MESH:D020149] (2214)  Substance-Related Disorders [MESH:D019966] (6308)   Amphetamine-Related Disorders [MESH:D019969] (2858) C26. Wounds and Injuries  C26. Wounds and Injuries  Wounds and Injuries [MESH:D014947] (5171)   Burns [MESH:D002056] (2565)  Craniocerebral Trauma [MESH:D006259] (3523)   Brain Injuries [MESH:D001930] (3431)  Trauma, Nervous System [MESH:D020196] (3535)   Craniocerebral Trauma [MESH:D006259] (3507)   Brain Injuries [MESH:D001930] (3431) D03. Heterocyclic Compounds  D03. Heterocyclic Compounds  Heterocyclic Compounds [MESH:D006571] (56330)   Alkaloids [MESH:D000470] (5036)   Indole Alkaloids [MESH:D026121] (1437)   Secologanin Tryptamine Alkaloids [MESH:D046948] (899)  Heterocyclic Compounds, 2-Ring [MESH:D006574] (24204)   Indoles [MESH:D007211] (4783)   Indole Alkaloids [MESH:D026121] (1458)   Secologanin Tryptamine Alkaloids [MESH:D046948] (899)