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 1,7-phenanthroline
C053486
 
  
  
  

MeSH Unique Identifier: C053486
Chemical – Gene Interaction

Note 1: 1,7-phenanthroline results in decreased activity of AKR1C1 protein

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C04. Neoplasms: Neoplasms [MESH:D009369] > Pregnancy Complications, Neoplastic [MESH:D011252]
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1. Human Genes 
1. Human Genes
 Aldo-keto reductases [HGNC:AKR] (282) 
 aldo-keto reductase family 1, member C1 [HGNC:AKR1C1] (148)
2. Interaction: Human Genes and Chemicals 
2. Interaction: Human Genes and Chemicals
 Decreases (5154) 
 activity (2549)
C04. Neoplasms 
C04. Neoplasms
 Neoplasms [MESH:D009369] (10293) 
 Hamartoma [MESH:D006222] (1484)
 Cysts [MESH:D003560] (2625) 
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
 Neoplasms by Histologic Type [MESH:D009370] (8793) 
 Neoplasms, Germ Cell and Embryonal [MESH:D009373] (5126) 
 Trophoblastic Neoplasms [MESH:D014328] (68) 
 Gestational Trophoblastic Disease [MESH:D031901] (65)
 Neoplasms, Glandular and Epithelial [MESH:D009375] (7760) 
 Carcinoma [MESH:D002277] (7263) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Squamous Cell [MESH:D002294] (4294)
 Adenocarcinoma [MESH:D000230] (6565) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Neoplasms, Squamous Cell [MESH:D018307] (4457) 
 Carcinoma, Squamous Cell [MESH:D002294] (4294)
 Neoplasms by Site [MESH:D009371] (9169) 
 Breast Neoplasms [MESH:D001943] (6077)
 Digestive System Neoplasms [MESH:D004067] (7487) 
 Gastrointestinal Neoplasms [MESH:D005770] (6452) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5358) 
 Colorectal Neoplasms [MESH:D015179] (5294)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Thoracic Neoplasms [MESH:D013899] (6032) 
 Respiratory Tract Neoplasms [MESH:D012142] (6020) 
 Lung Neoplasms [MESH:D008175] (6015) 
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Urogenital Neoplasms [MESH:D014565] (7002) 
 Genital Neoplasms, Female [MESH:D005833] (2540) 
 Uterine Neoplasms [MESH:D014594] (2431) 
 Endometrial Neoplasms [MESH:D016889] (1987)
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966)
 Ureteral Neoplasms [MESH:D014516] (574)
 Neoplasms, Experimental [MESH:D009374] (5218) 
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Metastasis [MESH:D009362] (4441)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Pregnancy Complications, Neoplastic [MESH:D011252] (71) 
 Trophoblastic Neoplasms [MESH:D014328] (67) 
 Gestational Trophoblastic Disease [MESH:D031901] (65)
C05. Musculoskeletal Diseases 
C05. Musculoskeletal Diseases
 Musculoskeletal Diseases [MESH:D009140] (8705) 
 Bone Diseases [MESH:D001847] (5801) 
 Bone Resorption [MESH:D001862] (2352)
 Joint Diseases [MESH:D007592] (4657) 
 Arthritis [MESH:D001168] (4416) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Osteoarthritis [MESH:D010003] (1743)
 Rheumatic Diseases [MESH:D012216] (4032) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Osteoarthritis [MESH:D010003] (1743)
C06. Digestive System Diseases 
C06. Digestive System Diseases
 Digestive System Diseases [MESH:D004066] (9461) 
 Digestive System Neoplasms [MESH:D004067] (7493) 
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Gastrointestinal Diseases [MESH:D005767] (7443) 
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294)
 Intestinal Diseases [MESH:D007410] (6206) 
 Colonic Diseases [MESH:D003108] (5564) 
 Colorectal Neoplasms [MESH:D015179] (5282)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294)
 Rectal Diseases [MESH:D012002] (4596) 
 Colorectal Neoplasms [MESH:D015179] (4534)
 Stomach Diseases [MESH:D013272] (5325) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Liver Diseases [MESH:D008107] (8167) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Hepatomegaly [MESH:D006529] (1169)
 Liver Cirrhosis [MESH:D008103] (5542) 
 Liver Cirrhosis, Experimental [MESH:D008106] (4589)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Pancreatic Diseases [MESH:D010182] (4453) 
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
C08. Respiratory Tract Diseases 
C08. Respiratory Tract Diseases
 Respiratory Tract Diseases [MESH:D012140] (7881) 
 Lung Diseases [MESH:D008171] (7249) 
 Pneumonia [MESH:D011014] (3482)
 Lung Diseases, Interstitial [MESH:D017563] (2966) 
 Pneumoconiosis [MESH:D011009] (2789) 
 Silicosis [MESH:D012829] (1273)
 Lung Diseases, Obstructive [MESH:D008173] (4697) 
 Pulmonary Disease, Chronic Obstructive [MESH:D029424] (3564)
 Lung Injury [MESH:D055370] (3688) 
 Pneumoconiosis [MESH:D011009] (2789) 
 Silicosis [MESH:D012829] (1273)
 Lung Neoplasms [MESH:D008175] (6012) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Respiration Disorders [MESH:D012120] (2218) 
 Hyperventilation [MESH:D006985] (654)
 Respiratory Tract Infections [MESH:D012141] (3926) 
 Pneumonia [MESH:D011014] (3482)
 Respiratory Tract Neoplasms [MESH:D012142] (6053) 
 Lung Neoplasms [MESH:D008175] (6013) 
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
C10. Nervous System Diseases 
C10. Nervous System Diseases
 Nervous System Diseases [MESH:D009422] (13325) 
 Chronobiology Disorders [MESH:D021081] (970)
 Central Nervous System Diseases [MESH:D002493] (9745) 
 Brain Diseases [MESH:D001927] (9294) 
 Basal Ganglia Diseases [MESH:D001480] (4268) 
 Parkinsonian Disorders [MESH:D020734] (4009)
 Movement Disorders [MESH:D009069] (4823) 
 Parkinsonian Disorders [MESH:D020734] (4009)
 Spinal Cord Diseases [MESH:D013118] (4376) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Neurodegenerative Diseases [MESH:D019636] (6613) 
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)
 Neuromuscular Diseases [MESH:D009468] (7336) 
 Peripheral Nervous System Diseases [MESH:D010523] (6151)
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)
C11. Eye Diseases 
C11. Eye Diseases
 Eye Diseases [MESH:D005128] (6245) 
 Ocular Hypertension [MESH:D009798] (1630)
C12. Male Urogenital Diseases 
C12. Male Urogenital Diseases
 Male Urogenital Diseases [MESH:D052801] (8891) 
 Genital Diseases, Male [MESH:D005832] (6794) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Infertility [MESH:D007246] (2909) 
 Infertility, Male [MESH:D007248] (2851)
 Prostatic Diseases [MESH:D011469] (6204) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urogenital Abnormalities [MESH:D014564] (2065) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XX Disorders of Sex Development [MESH:D058489] (644)
 Urogenital Neoplasms [MESH:D014565] (6932) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966)
 Ureteral Neoplasms [MESH:D014516] (574)
 Urologic Diseases [MESH:D014570] (7792) 
 Kidney Diseases [MESH:D007674] (7242) 
 Kidney Neoplasms [MESH:D007680] (3966)
 Ureteral Diseases [MESH:D014515] (1024) 
 Ureteral Neoplasms [MESH:D014516] (574)
C13. Female Urogenital Diseases and Pregnancy Complications 
C13. Female Urogenital Diseases and Pregnancy Complications
 Female Urogenital Diseases [MESH:D052776] (8724) 
 Genital Diseases, Female [MESH:D005831] (5563) 
 Endometriosis [MESH:D004715] (2461)
 Adnexal Diseases [MESH:D000291] (4273) 
 Ovarian Diseases [MESH:D010049] (4255) 
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
 Uterine Diseases [MESH:D014591] (2479) 
 Uterine Neoplasms [MESH:D014594] (2430) 
 Endometrial Neoplasms [MESH:D016889] (1984)
 Urogenital Abnormalities [MESH:D014564] (2043) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XX Disorders of Sex Development [MESH:D058489] (644)
 Urogenital Neoplasms [MESH:D014565] (5792) 
 Genital Neoplasms, Female [MESH:D005833] (3810) 
 Uterine Neoplasms [MESH:D014594] (2433) 
 Endometrial Neoplasms [MESH:D016889] (1989)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Kidney Neoplasms [MESH:D007680] (3966)
 Ureteral Neoplasms [MESH:D014516] (574)
 Urologic Diseases [MESH:D014570] (7793) 
 Kidney Diseases [MESH:D007674] (7242) 
 Kidney Neoplasms [MESH:D007680] (3966)
 Ureteral Diseases [MESH:D014515] (1024) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Pregnancy Complications [MESH:D011248] (4768) 
 Abortion, Spontaneous [MESH:D000022] (2780)
 Pregnancy Complications, Neoplastic [MESH:D011252] (71) 
 Trophoblastic Neoplasms [MESH:D014328] (67) 
 Gestational Trophoblastic Disease [MESH:D031901] (65)
C14. Cardiovascular Diseases 
C14. Cardiovascular Diseases
 Cardiovascular Diseases [MESH:D002318] (10123) 
 Cardiovascular Abnormalities [MESH:D018376] (3153) 
 Heart Defects, Congenital [MESH:D006330] (2447)
 Heart Diseases [MESH:D006331] (8614) 
 Cardiomegaly [MESH:D006332] (4081)
 Heart Defects, Congenital [MESH:D006330] (2443)
 Arrhythmias, Cardiac [MESH:D001145] (4679) 
 Tachycardia [MESH:D013610] (3339)
 Vascular Diseases [MESH:D014652] (8691) 
 Arteritis [MESH:D001167] (1084)
 Hypertension [MESH:D006973] (5655)
 Peripheral Vascular Diseases [MESH:D016491] (1412)
 Arterial Occlusive Diseases [MESH:D001157] (4520) 
 Arteriosclerosis [MESH:D001161] (4466) 
 Atherosclerosis [MESH:D050197] (4188)
 Vasculitis [MESH:D014657] (2604) 
 Arteritis [MESH:D001167] (1084)
C15. Hemic and Lymphatic Diseases 
C15. Hemic and Lymphatic Diseases
 Hematologic Diseases [MESH:D006402] (6174) 
 Methemoglobinemia [MESH:D008708] (850)
 Anemia [MESH:D000740] (3966) 
 Anemia, Hemolytic [MESH:D000743] (3083)
 Lymphatic Diseases [MESH:D008206] (5167) 
 Splenic Diseases [MESH:D013158] (1323)
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities 
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152) 
 Congenital Abnormalities [MESH:D000013] (8109) 
 Abnormalities, Drug-Induced [MESH:D000014] (1024)
 Cardiovascular Abnormalities [MESH:D018376] (3294) 
 Heart Defects, Congenital [MESH:D006330] (2611)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Urogenital Abnormalities [MESH:D014564] (2064) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XX Disorders of Sex Development [MESH:D058489] (644)
 Genetic Diseases, Inborn [MESH:D030342] (9766) 
 Metabolism, Inborn Errors [MESH:D008661] (6032) 
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Skin Diseases, Genetic [MESH:D012873] (3456) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
C17. Skin and Connective Tissue Diseases 
C17. Skin and Connective Tissue Diseases
 Connective Tissue Diseases [MESH:D003240] (4490) 
 Rheumatic Diseases [MESH:D012216] (3619) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Skin Diseases [MESH:D012871] (8774) 
 Breast Diseases [MESH:D001941] (6148) 
 Breast Neoplasms [MESH:D001943] (6077)
 Dermatitis [MESH:D003872] (4530) 
 Drug Eruptions [MESH:D003875] (2697)
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Skin Diseases, Eczematous [MESH:D017443] (3740) 
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Skin Diseases, Genetic [MESH:D012873] (3481) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Skin Diseases, Metabolic [MESH:D012875] (1574) 
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
C18. Nutritional and Metabolic Diseases 
C18. Nutritional and Metabolic Diseases
 Metabolic Diseases [MESH:D008659] (9025) 
 Glucose Metabolism Disorders [MESH:D044882] (6122) 
 Hypoglycemia [MESH:D007003] (2420)
 Diabetes Mellitus [MESH:D003920] (5891) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Lipid Metabolism Disorders [MESH:D052439] (3225) 
 Dyslipidemias [MESH:D050171] (2428)
 Metabolism, Inborn Errors [MESH:D008661] (6028) 
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Proteostasis Deficiencies [MESH:D057165] (3522) 
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296)
 Skin Diseases, Metabolic [MESH:D012875] (1574) 
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Water-Electrolyte Imbalance [MESH:D014883] (2790) 
 Hypokalemia [MESH:D007008] (1041)
 Nutrition Disorders [MESH:D009748] (4945) 
 Malnutrition [MESH:D044342] (2754) 
 Deficiency Diseases [MESH:D003677] (2742) 
 Protein Deficiency [MESH:D011488] (1057)
C19. Endocrine System Diseases 
C19. Endocrine System Diseases
 Endocrine System Diseases [MESH:D004700] (8062) 
 Diabetes Mellitus [MESH:D003920] (6159) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Gonadal Disorders [MESH:D006058] (5088) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XX Disorders of Sex Development [MESH:D058489] (644)
 Ovarian Diseases [MESH:D010049] (4253) 
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
 Thyroid Diseases [MESH:D013959] (2808) 
 Hyperthyroidism [MESH:D006980] (1191)
C20. Immune System Diseases 
C20. Immune System Diseases
 Immune System Diseases [MESH:D007154] (7674) 
 Autoimmune Diseases [MESH:D001327] (5067) 
 Arthritis, Rheumatoid [MESH:D001172] (3601)
 Hypersensitivity [MESH:D006967] (5873) 
 Drug Hypersensitivity [MESH:D004342] (4000) 
 Drug Eruptions [MESH:D003875] (2695)
 Hypersensitivity, Delayed [MESH:D006968] (3408) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Hypersensitivity, Immediate [MESH:D006969] (4980) 
 Food Hypersensitivity [MESH:D005512] (608) 
 Peanut Hypersensitivity [MESH:D021183] (572)
C23. Pathological Conditions, Signs and Symptoms 
C23. Pathological Conditions, Signs and Symptoms
 Pathological Conditions, Anatomical [MESH:D020763] (6074) 
 Atrophy [MESH:D001284] (2603)
 Hypertrophy [MESH:D006984] (4476) 
 Cardiomegaly [MESH:D006332] (3802)
 Hepatomegaly [MESH:D006529] (1169)
 Splenomegaly [MESH:D013163] (1258)
 Pathologic Processes [MESH:D010335] (9863) 
 Growth Disorders [MESH:D006130] (2438)
 Inflammation [MESH:D007249] (5241)
 Arrhythmias, Cardiac [MESH:D001145] (4658) 
 Tachycardia [MESH:D013610] (3339)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Metastasis [MESH:D009362] (4441)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Signs and Symptoms [MESH:D012816] (10659) 
 Edema [MESH:D004487] (3726)
 Signs and Symptoms, Respiratory [MESH:D012818] (2724) 
 Hyperoxia [MESH:D018496] (694)
 Hyperventilation [MESH:D006985] (652)
C24. Occupational Diseases 
C24. Occupational Diseases
 Z. Exceptions (1530) 
 Not Fully Specified [NFS] (1530)
 Occupational Diseases [MESH:D009784] (3402) 
 Pneumoconiosis [MESH:D011009] (2670) 
 Silicosis [MESH:D012829] (1273)
C25. Chemically-Induced Disorders 
C25. Chemically-Induced Disorders
 Drug-Related Side Effects and Adverse Reactions [MESH:D064420] (5839) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Drug Hypersensitivity [MESH:D004342] (4001) 
 Drug Eruptions [MESH:D003875] (2697)
 Poisoning [MESH:D011041] (6703) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Substance-Related Disorders [MESH:D019966] (6308) 
 Amphetamine-Related Disorders [MESH:D019969] (2858)
 Cocaine-Related Disorders [MESH:D019970] (3054)
D03. Heterocyclic Compounds 
D03. Heterocyclic Compounds
 Heterocyclic Compounds [MESH:D006571] (56330) 
 Heterocyclic Compounds, 3-Ring [MESH:D006575] (3947) 
 Phenanthrolines [MESH:D010618] (179)