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 romidepsin
C087123		 
  
  
  

MeSH Unique Identifier: C087123
Scope Notes: A bicyclic depsipeptide and a potent histone deacetylase inhibitor from Chromobacterium violaceum
Chemical – Gene Interaction

Note 1: ABCB1 protein binds to and affects the export of romidepsin

Note 2: ABCB1 protein results in decreased susceptibility to romidepsin

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C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities: Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] > Genetic Diseases, Inborn [MESH:D030342] > Polycystic Kidney, Autosomal Recessive [MESH:D017044]
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more general categories    information about this item
1. Human Genes 
1. Human Genes
 Ankyrin repeat domain containing [HGNC:ANKRD] (566) 
 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [HGNC:NFKB1] (254)
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [HGNC:NFKBIA] (290)
 ATP-binding cassette transporters [HGNC:ABC] (821) 
 ATP-binding cassette transporters, subfamily B [HGNC:ABCB] (452) 
 ATP-binding cassette, sub-family B (MDR/TAP), member 01 [HGNC:ABCB1] (355)
 ATP-binding cassette transporters, subfamily C [HGNC:ABCC] (458) 
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [HGNC:ABCC1] (177)
 CD molecules [HGNC:CD] (1459) 
 ATP-binding cassette, sub-family B (MDR/TAP), member 01 [HGNC:ABCB1] (355)
 intercellular adhesion molecule 1 [HGNC:ICAM1] (286)
 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 [HGNC:ERBB2] (109)
 Cytochrome P450s [HGNC:CYP] (1673) 
 cytochrome P450, family 01, subfamily A, polypeptide 01 [HGNC:CYP1A1] (566)
 cytochrome P450, family 02, subfamily B, polypeptide 06 [HGNC:CYP2B6] (216)
 cytochrome P450, family 03, subfamily A, polypeptide 04 [HGNC:CYP3A4] (612)
 cytochrome P450, family 03, subfamily A, polypeptide 05 [HGNC:CYP3A5] (134)
 Histones [HGNC:HIST] (173) 
 Histones, Replication-independent [HGNC:RIH] (148) 
 H2A histone family, member X [HGNC:H2AFX] (129)
 Immunoglobulin superfamily domain containing [HGNC:IGSF] (761) 
 Immunoglobulin-like domain containing [HGNC:IGD] (645) 
 intercellular adhesion molecule 1 [HGNC:ICAM1] (286)
 Mitogen-activated protein kinase cascade [HGNC:MAP#K] (854) 
 Mitogen-activated protein kinases [HGNC:MAPK] (797) 
 mitogen-activated protein kinase 01 [HGNC:MAPK1] (651)
 mitogen-activated protein kinase 03 [HGNC:MAPK3] (644)
 Nuclear hormone receptors [HGNC:NR] (1322) 
 nuclear receptor subfamily 1, group I, member 3 [HGNC:NR1I3] (123)
 RNA binding motif containing [HGNC:RRM] (251) 
 EWS RNA-binding protein 1 [HGNC:EWSR1] (14)
2. Interaction: Human Genes and Chemicals 
2. Interaction: Human Genes and Chemicals
 Affects (3990) 
 binding (2423)
 cotreatment (1499)
 export (67)
 metabolic processing (485)
 Decreases (5154) 
 activity (2549)
 expression (2187)
 phosphorylation (590)
 reaction (3393)
 response to substance (713)
 Increases (5571) 
 acetylation (96)
 activity (2865)
 cleavage (666)
 expression (3238)
 phosphorylation (1060)
 reaction (1574)
C01. Bacterial Infections and Mycoses 
C01. Bacterial Infections and Mycoses
 Bacterial Infections [MESH:D001424] (3716) 
 Gram-Negative Bacterial Infections [MESH:D016905] (3085) 
 Mycoplasmatales Infections [MESH:D009180] (1949) 
 Mycoplasma Infections [MESH:D009175] (1947)
 Infection [MESH:D007239] (4109) 
 Sepsis [MESH:D018805] (3556)
C02. Virus Diseases 
C02. Virus Diseases
 Virus Diseases [MESH:D014777] (4544) 
 Hepatitis, Viral, Human [MESH:D006525] (1766) 
 Hepatitis C [MESH:D006526] (1627)
 RNA Virus Infections [MESH:D012327] (4215) 
 Flaviviridae Infections [MESH:D018178] (1656) 
 Hepatitis C [MESH:D006526] (1627)
 Mononegavirales Infections [MESH:D018701] (900) 
 Paramyxoviridae Infections [MESH:D018184] (889) 
 Pneumovirus Infections [MESH:D018186] (853) 
 Respiratory Syncytial Virus Infections [MESH:D018357] (852)
 Retroviridae Infections [MESH:D012192] (3420) 
 Lentivirus Infections [MESH:D016180] (3408) 
 HIV Infections [MESH:D015658] (3402)
 Sexually Transmitted Diseases [MESH:D012749] (3305) 
 Sexually Transmitted Diseases, Viral [MESH:D015229] (3304) 
 HIV Infections [MESH:D015658] (3296)
C03. Parasitic Diseases 
C03. Parasitic Diseases
 Parasitic Diseases [MESH:D010272] (3828) 
 Protozoan Infections [MESH:D011528] (3014) 
 Malaria [MESH:D008288] (2175)
C04. Neoplasms 
C04. Neoplasms
 Neoplasms [MESH:D009369] (10293) 
 Hamartoma [MESH:D006222] (1484)
 Precancerous Conditions [MESH:D011230] (2858)
 Cysts [MESH:D003560] (2625) 
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
 Neoplasms by Histologic Type [MESH:D009370] (8793) 
 Leukemia [MESH:D007938] (4576) 
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Leukemia, Myeloid [MESH:D007951] (2773) 
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive [MESH:D015464] (1032)
 Leukemia, Myeloid, Acute [MESH:D015470] (2176) 
 Leukemia, Megakaryoblastic, Acute [MESH:D007947] (279)
 Lymphoma [MESH:D008223] (3686) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3337) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
 Lymphoma, T-Cell [MESH:D016399] (1405) 
 Lymphoma, Extranodal NK-T-Cell [MESH:D054391] (132)
 Lymphoma, T-Cell, Cutaneous [MESH:D016410] (912)
 Neoplasms, Connective and Soft Tissue [MESH:D018204] (4742) 
 Neoplasms, Connective Tissue [MESH:D009372] (3626) 
 Neoplasms, Bone Tissue [MESH:D018213] (2217) 
 Osteosarcoma [MESH:D012516] (2175) 
 Sarcoma, Ewing [MESH:D012512] (79)
 Sarcoma [MESH:D012509] (4246) 
 Osteosarcoma [MESH:D012516] (2175) 
 Sarcoma, Ewing [MESH:D012512] (79)
 Neoplasms, Germ Cell and Embryonal [MESH:D009373] (5126) 
 Neuroectodermal Tumors [MESH:D017599] (5066) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Retinoblastoma [MESH:D012175] (319)
 Glioma [MESH:D005910] (4261) 
 Gliosarcoma [MESH:D018316] (880)
 Medulloblastoma [MESH:D008527] (1282)
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Medulloblastoma [MESH:D008527] (1282)
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Glandular and Epithelial [MESH:D009375] (7760) 
 Adenoma [MESH:D000236] (4051) 
 Mesothelioma [MESH:D008654] (2567)
 Carcinoma [MESH:D002277] (7263) 
 Carcinoma, Small Cell [MESH:D018288] (1317)
 Carcinoma, Transitional Cell [MESH:D002295] (2662)
 Adenocarcinoma [MESH:D000230] (6565) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Cholangiocarcinoma [MESH:D018281] (2398)
 Carcinoma, Squamous Cell [MESH:D002294] (4294) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Neoplasms, Mesothelial [MESH:D018301] (2569) 
 Mesothelioma [MESH:D008654] (2567)
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Retinoblastoma [MESH:D012175] (319)
 Glioma [MESH:D005910] (4261) 
 Gliosarcoma [MESH:D018316] (880)
 Medulloblastoma [MESH:D008527] (1282)
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Medulloblastoma [MESH:D008527] (1282)
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Squamous Cell [MESH:D018307] (4457) 
 Papilloma [MESH:D010212] (2243)
 Carcinoma, Squamous Cell [MESH:D002294] (4294) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Neoplasms, Nerve Tissue [MESH:D009380] (5201) 
 Neuroectodermal Tumors [MESH:D017599] (5059) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Retinoblastoma [MESH:D012175] (319)
 Glioma [MESH:D005910] (4261) 
 Gliosarcoma [MESH:D018316] (880)
 Medulloblastoma [MESH:D008527] (1282)
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Medulloblastoma [MESH:D008527] (1282)
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Plasma Cell [MESH:D054219] (2772) 
 Multiple Myeloma [MESH:D009101] (2767)
 Neoplasms by Site [MESH:D009371] (9169) 
 Breast Neoplasms [MESH:D001943] (6077)
 Digestive System Neoplasms [MESH:D004067] (7487) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Biliary Tract Neoplasms [MESH:D001661] (1165) 
 Bile Duct Neoplasms [MESH:D001650] (367)
 Gastrointestinal Neoplasms [MESH:D005770] (6452) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5358) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Rectal Neoplasms [MESH:D012004] (717)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Ovarian Neoplasms [MESH:D010051] (3275)
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Eye Neoplasms [MESH:D005134] (400) 
 Retinal Neoplasms [MESH:D019572] (320) 
 Retinoblastoma [MESH:D012175] (319)
 Head and Neck Neoplasms [MESH:D006258] (4612) 
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Otorhinolaryngologic Neoplasms [MESH:D010039] (1557) 
 Pharyngeal Neoplasms [MESH:D010610] (1520) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
 Mammary Neoplasms, Animal [MESH:D015674] (3404) 
 Mammary Neoplasms, Experimental [MESH:D008325] (3268)
 Nervous System Neoplasms [MESH:D009423] (3130) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Thoracic Neoplasms [MESH:D013899] (6032) 
 Respiratory Tract Neoplasms [MESH:D012142] (6020) 
 Lung Neoplasms [MESH:D008175] (6015) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
 Urogenital Neoplasms [MESH:D014565] (7002) 
 Genital Neoplasms, Female [MESH:D005833] (2540) 
 Uterine Neoplasms [MESH:D014594] (2431) 
 Endometrial Neoplasms [MESH:D016889] (1987)
 Uterine Cervical Neoplasms [MESH:D002583] (978)
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Neoplasms, Experimental [MESH:D009374] (5218) 
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Mammary Neoplasms, Experimental [MESH:D008325] (3268)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Invasiveness [MESH:D009361] (3388)
 Neoplasm Recurrence, Local [MESH:D009364] (1949)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Neoplasm Metastasis [MESH:D009362] (4441) 
 Lymphatic Metastasis [MESH:D008207] (917)
C05. Musculoskeletal Diseases 
C05. Musculoskeletal Diseases
 Musculoskeletal Diseases [MESH:D009140] (8705) 
 Bone Diseases [MESH:D001847] (5801) 
 Spinal Diseases [MESH:D013122] (2485) 
 Spinal Curvatures [MESH:D013121] (742) 
 Kyphosis [MESH:D007738] (637)
 Joint Diseases [MESH:D007592] (4657) 
 Arthritis [MESH:D001168] (4416) 
 Arthritis, Experimental [MESH:D001169] (3142)
 Muscular Diseases [MESH:D009135] (4071) 
 Muscular Disorders, Atrophic [MESH:D020966] (1598) 
 Muscular Dystrophies [MESH:D009136] (1593) 
 Muscular Dystrophy, Facioscapulohumeral [MESH:D020391] (854)
 Musculoskeletal Abnormalities [MESH:D009139] (3796) 
 Craniofacial Abnormalities [MESH:D019465] (3098) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
C06. Digestive System Diseases 
C06. Digestive System Diseases
 Digestive System Diseases [MESH:D004066] (9461) 
 Biliary Tract Diseases [MESH:D001660] (3845) 
 Bile Duct Diseases [MESH:D001649] (3512) 
 Bile Duct Neoplasms [MESH:D001650] (367)
 Cholestasis [MESH:D002779] (3419) 
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Biliary Tract Neoplasms [MESH:D001661] (1165) 
 Bile Duct Neoplasms [MESH:D001650] (367)
 Digestive System Abnormalities [MESH:D004065] (2127) 
 Barrett Esophagus [MESH:D001471] (1930)
 Digestive System Neoplasms [MESH:D004067] (7493) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Biliary Tract Neoplasms [MESH:D001661] (1165) 
 Bile Duct Neoplasms [MESH:D001650] (367)
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Rectal Neoplasms [MESH:D012004] (717)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Gastrointestinal Diseases [MESH:D005767] (7443) 
 Esophageal Diseases [MESH:D004935] (4255) 
 Barrett Esophagus [MESH:D001471] (1930)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Gastroenteritis [MESH:D005759] (4066) 
 Colitis [MESH:D003092] (3199) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Inflammatory Bowel Disease 13 [MESH:C567384] (435)
 Colitis, Ulcerative [MESH:D003093] (2601)
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Rectal Neoplasms [MESH:D012004] (717)
 Intestinal Diseases [MESH:D007410] (6206) 
 Colonic Diseases [MESH:D003108] (5564) 
 Colitis [MESH:D003092] (3199) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Colorectal Neoplasms [MESH:D015179] (5282) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Inflammatory Bowel Disease 13 [MESH:C567384] (435)
 Colitis, Ulcerative [MESH:D003093] (2601)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Rectal Neoplasms [MESH:D012004] (717)
 Rectal Diseases [MESH:D012002] (4596) 
 Colorectal Neoplasms [MESH:D015179] (4534) 
 Rectal Neoplasms [MESH:D012004] (717)
 Peptic Ulcer [MESH:D010437] (3172) 
 Stomach Ulcer [MESH:D013276] (2915)
 Stomach Diseases [MESH:D013272] (5325) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Peptic Ulcer [MESH:D010437] (2994) 
 Stomach Ulcer [MESH:D013276] (2915)
 Liver Diseases [MESH:D008107] (8167) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Hepatitis [MESH:D006505] (3883) 
 Hepatitis, Viral, Human [MESH:D006525] (1766) 
 Hepatitis C [MESH:D006526] (1627)
 Liver Cirrhosis [MESH:D008103] (5542) 
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Liver Cirrhosis, Experimental [MESH:D008106] (4589)
 Liver Diseases, Alcoholic [MESH:D008108] (3243) 
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Pancreatic Diseases [MESH:D010182] (4453) 
 Pancreatic Neoplasms [MESH:D010190] (3820)
C07. Stomatognathic Diseases 
C07. Stomatognathic Diseases
 Stomatognathic Diseases [MESH:D009057] (5348) 
 Mouth Diseases [MESH:D009059] (4783) 
 Behcet Syndrome [MESH:D001528] (1784)
 Pharyngeal Diseases [MESH:D010608] (1562) 
 Nasopharyngeal Diseases [MESH:D009302] (1508) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
 Pharyngeal Neoplasms [MESH:D010610] (1520) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
C08. Respiratory Tract Diseases 
C08. Respiratory Tract Diseases
 Respiratory Tract Diseases [MESH:D012140] (7881) 
 Bronchial Diseases [MESH:D001982] (4382) 
 Asthma [MESH:D001249] (4098)
 Bronchial Hyperreactivity [MESH:D016535] (1357)
 Bronchiectasis [MESH:D001987] (1792)
 Lung Diseases [MESH:D008171] (7249) 
 Pneumonia [MESH:D011014] (3482)
 Lung Diseases, Obstructive [MESH:D008173] (4697) 
 Asthma [MESH:D001249] (3903)
 Pulmonary Disease, Chronic Obstructive [MESH:D029424] (3564)
 Lung Injury [MESH:D055370] (3688) 
 Acute Lung Injury [MESH:D055371] (1907)
 Lung Neoplasms [MESH:D008175] (6012) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
 Pleural Diseases [MESH:D010995] (2240) 
 Pleurisy [MESH:D010998] (2070)
 Respiratory Hypersensitivity [MESH:D012130] (4401) 
 Asthma [MESH:D001249] (4098)
 Respiratory Tract Infections [MESH:D012141] (3926) 
 Pleurisy [MESH:D010998] (2070)
 Pneumonia [MESH:D011014] (3482)
 Respiratory Tract Neoplasms [MESH:D012142] (6053) 
 Lung Neoplasms [MESH:D008175] (6013) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
C09. Otorhinolaryngologic Diseases 
C09. Otorhinolaryngologic Diseases
 Otorhinolaryngologic Diseases [MESH:D010038] (3827) 
 Ear Diseases [MESH:D004427] (2522) 
 Hearing Disorders [MESH:D006311] (2103) 
 Hearing Loss [MESH:D034381] (2068)
 Otorhinolaryngologic Neoplasms [MESH:D010039] (1561) 
 Pharyngeal Neoplasms [MESH:D010610] (1520) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
 Pharyngeal Diseases [MESH:D010608] (1605) 
 Nasopharyngeal Diseases [MESH:D009302] (1508) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
 Pharyngeal Neoplasms [MESH:D010610] (1520) 
 Nasopharyngeal Neoplasms [MESH:D009303] (1500)
C10. Nervous System Diseases 
C10. Nervous System Diseases
 Z. Exceptions (4027) 
 Not Fully Specified [NFS] (4027)
 Nervous System Diseases [MESH:D009422] (13325) 
 Neurotoxicity Syndromes [MESH:D020258] (4570)
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Autonomic Nervous System Diseases [MESH:D001342] (882) 
 Primary Dysautonomias [MESH:D054969] (775) 
 Orthostatic Intolerance [MESH:D054971] (720) 
 Hypotension, Orthostatic [MESH:D007024] (679)
 Central Nervous System Diseases [MESH:D002493] (9745) 
 Brain Diseases [MESH:D001927] (9294) 
 Brain Injuries [MESH:D001930] (3429)
 Brain Neoplasms [MESH:D001932] (2764)
 Basal Ganglia Diseases [MESH:D001480] (4268) 
 Parkinsonian Disorders [MESH:D020734] (4009) 
 Parkinson Disease [MESH:D010300] (3595)
 Cerebrovascular Disorders [MESH:D002561] (5542) 
 Brain Ischemia [MESH:D002545] (4873) 
 Ischemic Attack, Transient [MESH:D002546] (1313)
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2463) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Hemorrhages [MESH:D020300] (3269) 
 Cerebral Hemorrhage [MESH:D002543] (2873)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Dementia [MESH:D003704] (4498) 
 Alzheimer Disease [MESH:D000544] (4275)
 Epilepsy [MESH:D004827] (6274) 
 Status Epilepticus [MESH:D013226] (4014)
 Movement Disorders [MESH:D009069] (4823) 
 Parkinsonian Disorders [MESH:D020734] (4009) 
 Parkinson Disease [MESH:D010300] (3595)
 Spinal Cord Diseases [MESH:D013118] (4376) 
 Spinal Cord Injuries [MESH:D013119] (1674)
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Demyelinating Diseases [MESH:D003711] (2917) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (2035) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Nervous System Neoplasms [MESH:D009423] (3073) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Neurodegenerative Diseases [MESH:D019636] (6613) 
 Parkinson Disease [MESH:D010300] (3595)
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3243) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Tauopathies [MESH:D024801] (4289) 
 Alzheimer Disease [MESH:D000544] (4275)
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Neurologic Manifestations [MESH:D009461] (8964) 
 Sensation Disorders [MESH:D012678] (5011) 
 Hearing Disorders [MESH:D006311] (2103) 
 Hearing Loss [MESH:D034381] (2068)
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Neuromuscular Diseases [MESH:D009468] (7336) 
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Muscular Diseases [MESH:D009135] (3538) 
 Muscular Disorders, Atrophic [MESH:D020966] (1594) 
 Muscular Dystrophies [MESH:D009136] (1589) 
 Muscular Dystrophy, Facioscapulohumeral [MESH:D020391] (854)
 Peripheral Nervous System Diseases [MESH:D010523] (6151) 
 Diabetic Neuropathies [MESH:D003929] (2442)
 Sleep Disorders [MESH:D012893] (2050) 
 Dyssomnias [MESH:D020920] (1417) 
 Sleep Deprivation [MESH:D012892] (233)
 Trauma, Nervous System [MESH:D020196] (3997) 
 Spinal Cord Injuries [MESH:D013119] (1676)
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
C11. Eye Diseases 
C11. Eye Diseases
 Eye Diseases [MESH:D005128] (6245) 
 Eye Neoplasms [MESH:D005134] (413) 
 Retinal Neoplasms [MESH:D019572] (320) 
 Retinoblastoma [MESH:D012175] (319)
 Retinal Diseases [MESH:D012164] (3747) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Retinal Detachment [MESH:D012163] (1639)
 Retinal Neoplasms [MESH:D019572] (320) 
 Retinoblastoma [MESH:D012175] (319)
 Uveal Diseases [MESH:D014603] (2428) 
 Uveitis [MESH:D014605] (2157) 
 Panuveitis [MESH:D015864] (1805) 
 Uveitis, Anterior [MESH:D014606] (1791) 
 Behcet Syndrome [MESH:D001528] (1784)
C12. Male Urogenital Diseases 
C12. Male Urogenital Diseases
 Male Urogenital Diseases [MESH:D052801] (8891) 
 Genital Diseases, Male [MESH:D005832] (6794) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Infertility [MESH:D007246] (2909) 
 Infertility, Male [MESH:D007248] (2851)
 Prostatic Diseases [MESH:D011469] (6204) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Sexual Dysfunction, Physiological [MESH:D012735] (1808) 
 Erectile Dysfunction [MESH:D007172] (1791)
 Urogenital Neoplasms [MESH:D014565] (6932) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7792) 
 Kidney Diseases [MESH:D007674] (7242) 
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hyperoxaluria [MESH:D006959] (1498)
 Nephrosis [MESH:D009401] (2228)
 Uremia [MESH:D014511] (2898)
 Kidney Diseases, Cystic [MESH:D052177] (1009) 
 Polycystic Kidney Diseases [MESH:D007690] (853) 
 Polycystic Kidney, Autosomal Recessive [MESH:D017044] (462)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Renal Insufficiency [MESH:D051437] (4951) 
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Urinary Bladder Diseases [MESH:D001745] (4374) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
C13. Female Urogenital Diseases and Pregnancy Complications 
C13. Female Urogenital Diseases and Pregnancy Complications
 Female Urogenital Diseases [MESH:D052776] (8724) 
 Genital Diseases, Female [MESH:D005831] (5563) 
 Endometriosis [MESH:D004715] (2461)
 Adnexal Diseases [MESH:D000291] (4273) 
 Ovarian Diseases [MESH:D010049] (4255) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
 Infertility [MESH:D007246] (2211) 
 Infertility, Female [MESH:D007247] (2184)
 Uterine Diseases [MESH:D014591] (2479) 
 Uterine Cervical Diseases [MESH:D002577] (988) 
 Uterine Cervical Neoplasms [MESH:D002583] (978)
 Uterine Neoplasms [MESH:D014594] (2430) 
 Endometrial Neoplasms [MESH:D016889] (1984)
 Uterine Cervical Neoplasms [MESH:D002583] (978)
 Urogenital Neoplasms [MESH:D014565] (5792) 
 Genital Neoplasms, Female [MESH:D005833] (3810) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Uterine Neoplasms [MESH:D014594] (2433) 
 Endometrial Neoplasms [MESH:D016889] (1989)
 Uterine Cervical Neoplasms [MESH:D002583] (978)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7793) 
 Kidney Diseases [MESH:D007674] (7242) 
 Diabetic Nephropathies [MESH:D003928] (2301)
 Hyperoxaluria [MESH:D006959] (1498)
 Nephrosis [MESH:D009401] (2228)
 Uremia [MESH:D014511] (2898)
 Kidney Diseases, Cystic [MESH:D052177] (1009) 
 Polycystic Kidney Diseases [MESH:D007690] (853) 
 Polycystic Kidney, Autosomal Recessive [MESH:D017044] (462)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Renal Insufficiency [MESH:D051437] (4951) 
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Urinary Bladder Diseases [MESH:D001745] (4375) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Pregnancy Complications [MESH:D011248] (4768) 
 Abortion, Spontaneous [MESH:D000022] (2780)
C14. Cardiovascular Diseases 
C14. Cardiovascular Diseases
 Z. Exceptions (2667) 
 Not Fully Specified [NFS] (2667)
 Cardiovascular Diseases [MESH:D002318] (10123) 
 Cardiovascular Abnormalities [MESH:D018376] (3153) 
 Heart Defects, Congenital [MESH:D006330] (2447) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
 Heart Diseases [MESH:D006331] (8614) 
 Heart Failure [MESH:D006333] (4058)
 Arrhythmias, Cardiac [MESH:D001145] (4679) 
 Tachycardia [MESH:D013610] (3339) 
 Tachycardia, Ventricular [MESH:D017180] (1386) 
 Torsades de Pointes [MESH:D016171] (880)
 Cardiomegaly [MESH:D006332] (4081) 
 Cardiomyopathy, Dilated [MESH:D002311] (1576)
 Cardiomyopathies [MESH:D009202] (5331) 
 Cardiomyopathy, Dilated [MESH:D002311] (1576)
 Cardiomyopathy, Hypertrophic [MESH:D002312] (1516)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Heart Defects, Congenital [MESH:D006330] (2443) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
 Heart Valve Diseases [MESH:D006349] (3333) 
 Aortic Valve Stenosis [MESH:D001024] (1742) 
 Aortic Stenosis, Subvalvular [MESH:D001020] (1455) 
 Cardiomyopathy, Hypertrophic [MESH:D002312] (1451)
 Pulmonary Valve Stenosis [MESH:D011666] (360) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Myocardial Ischemia [MESH:D017202] (5787) 
 Myocardial Infarction [MESH:D009203] (4122)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Vascular Diseases [MESH:D014652] (8691) 
 Arteritis [MESH:D001167] (1084)
 Peripheral Vascular Diseases [MESH:D016491] (1412)
 Arterial Occlusive Diseases [MESH:D001157] (4520) 
 Arteriosclerosis [MESH:D001161] (4466) 
 Atherosclerosis [MESH:D050197] (4188)
 Cerebrovascular Disorders [MESH:D002561] (5541) 
 Brain Ischemia [MESH:D002545] (4873) 
 Ischemic Attack, Transient [MESH:D002546] (1313)
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2468) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Hemorrhages [MESH:D020300] (3269) 
 Cerebral Hemorrhage [MESH:D002543] (2873)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Embolism and Thrombosis [MESH:D016769] (3374) 
 Thrombosis [MESH:D013927] (3101)
 Hemostatic Disorders [MESH:D020141] (2894) 
 Multiple Myeloma [MESH:D009101] (2765)
 Hypertension [MESH:D006973] (5655) 
 Hypertension, Essential [MESH:C562386] (1308)
 Hypotension [MESH:D007022] (4045) 
 Hypotension, Orthostatic [MESH:D007024] (679)
 Myocardial Ischemia [MESH:D017202] (5791) 
 Myocardial Infarction [MESH:D009203] (4151)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Vasculitis [MESH:D014657] (2604) 
 Arteritis [MESH:D001167] (1084)
 Behcet Syndrome [MESH:D001528] (1784)
C15. Hemic and Lymphatic Diseases 
C15. Hemic and Lymphatic Diseases
 Hematologic Diseases [MESH:D006402] (6174) 
 Anemia [MESH:D000740] (3966)
 Blood Protein Disorders [MESH:D001796] (3051) 
 Paraproteinemias [MESH:D010265] (2781) 
 Multiple Myeloma [MESH:D009101] (2765)
 Bone Marrow Diseases [MESH:D001855] (2944) 
 Myelodysplastic Syndromes [MESH:D009190] (2093)
 Myeloproliferative Disorders [MESH:D009196] (1492) 
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive [MESH:D015464] (1032)
 Hemorrhagic Disorders [MESH:D006474] (3359) 
 Hemostatic Disorders [MESH:D020141] (2932) 
 Multiple Myeloma [MESH:D009101] (2765)
 Leukocyte Disorders [MESH:D007960] (2662) 
 Leukostasis [MESH:D018921] (769)
 Leukopenia [MESH:D007970] (1921) 
 Agranulocytosis [MESH:D000380] (1675) 
 Neutropenia [MESH:D009503] (1629)
 Lymphatic Diseases [MESH:D008206] (5167) 
 Lymphoproliferative Disorders [MESH:D008232] (4638) 
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Lymphoma [MESH:D008223] (3684) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3330) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
 Lymphoma, T-Cell [MESH:D016399] (1204) 
 Lymphoma, T-Cell, Cutaneous [MESH:D016410] (912)
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities 
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152) 
 Congenital Abnormalities [MESH:D000013] (8109) 
 Abnormalities, Multiple [MESH:D000015] (3192) 
 Ectodermal Dysplasia [MESH:D004476] (938) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Cardiovascular Abnormalities [MESH:D018376] (3294) 
 Heart Defects, Congenital [MESH:D006330] (2611) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
 Musculoskeletal Abnormalities [MESH:D009139] (3779) 
 Craniofacial Abnormalities [MESH:D019465] (3064) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Skin Abnormalities [MESH:D012868] (1723) 
 Ectodermal Dysplasia [MESH:D004476] (958) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
 Genetic Diseases, Inborn [MESH:D030342] (9766) 
 Polycystic Kidney, Autosomal Recessive [MESH:D017044] (462)
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3465) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Metabolism, Inborn Errors [MESH:D008661] (6032) 
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Muscular Dystrophies [MESH:D009136] (1597) 
 Muscular Dystrophy, Facioscapulohumeral [MESH:D020391] (854)
 Skin Diseases, Genetic [MESH:D012873] (3456) 
 Ectodermal Dysplasia [MESH:D004476] (958) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
C17. Skin and Connective Tissue Diseases 
C17. Skin and Connective Tissue Diseases
 Connective Tissue Diseases [MESH:D003240] (4490) 
 Noonan Syndrome [MESH:D009634] (506) 
 Noonan Syndrome 5 [MESH:C548083] (169)
 Skin Diseases [MESH:D012871] (8774) 
 Acneiform Eruptions [MESH:D017486] (1312) 
 Chloracne [MESH:D054506] (1274)
 Breast Diseases [MESH:D001941] (6148) 
 Breast Neoplasms [MESH:D001943] (6077)
 Dermatitis [MESH:D003872] (4530) 
 Drug Eruptions [MESH:D003875] (2697)
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Facial Dermatoses [MESH:D005148] (1336) 
 Acneiform Eruptions [MESH:D017486] (1312) 
 Chloracne [MESH:D054506] (1274)
 Hair Diseases [MESH:D006201] (1891) 
 Hypotrichosis [MESH:D007039] (1513) 
 Alopecia [MESH:D000505] (1453)
 Pigmentation Disorders [MESH:D010859] (1215) 
 Hyperpigmentation [MESH:D017495] (523) 
 Melanosis [MESH:D008548] (459) 
 Lentigo [MESH:D007911] (329) 
 LEOPARD Syndrome [MESH:D044542] (299) 
 LEOPARD syndrome, 2 [MESH:C537117] (169)
 Skin Abnormalities [MESH:D012868] (1709) 
 Ectodermal Dysplasia [MESH:D004476] (958) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
 Skin Diseases, Eczematous [MESH:D017443] (3740) 
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Skin Diseases, Genetic [MESH:D012873] (3481) 
 Ectodermal Dysplasia [MESH:D004476] (958) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
 Skin Diseases, Papulosquamous [MESH:D017444] (3392) 
 Psoriasis [MESH:D011565] (3278)
 Skin Diseases, Vascular [MESH:D017445] (3288) 
 Behcet Syndrome [MESH:D001528] (1784)
 Urticaria [MESH:D014581] (2668)
C18. Nutritional and Metabolic Diseases 
C18. Nutritional and Metabolic Diseases
 Metabolic Diseases [MESH:D008659] (9025) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Calcium Metabolism Disorders [MESH:D002128] (3634) 
 Calcinosis [MESH:D002114] (2989)
 Glucose Metabolism Disorders [MESH:D044882] (6122) 
 Diabetes Mellitus [MESH:D003920] (5891) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Hyperinsulinism [MESH:D006946] (3586) 
 Insulin Resistance [MESH:D007333] (3511) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Lipid Metabolism Disorders [MESH:D052439] (3225) 
 Dyslipidemias [MESH:D050171] (2428) 
 Hyperlipidemias [MESH:D006949] (1908) 
 Hypercholesterolemia [MESH:D006937] (1404)
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Metabolism, Inborn Errors [MESH:D008661] (6028) 
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Proteostasis Deficiencies [MESH:D057165] (3522) 
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Nutrition Disorders [MESH:D009748] (4945) 
 Malnutrition [MESH:D044342] (2754) 
 Deficiency Diseases [MESH:D003677] (2742) 
 Avitaminosis [MESH:D001361] (2304) 
 Vitamin A Deficiency [MESH:D014802] (705)
 Overnutrition [MESH:D044343] (4463) 
 Obesity [MESH:D009765] (4462)
C19. Endocrine System Diseases 
C19. Endocrine System Diseases
 Endocrine System Diseases [MESH:D004700] (8062) 
 Diabetes Mellitus [MESH:D003920] (6159) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Diabetes Complications [MESH:D048909] (4129) 
 Diabetic Nephropathies [MESH:D003928] (2301)
 Diabetic Neuropathies [MESH:D003929] (2443)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Ovarian Neoplasms [MESH:D010051] (3275)
 Pancreatic Neoplasms [MESH:D010190] (3820)
 Gonadal Disorders [MESH:D006058] (5088) 
 Ovarian Diseases [MESH:D010049] (4253) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Ovarian Cysts [MESH:D010048] (2534) 
 Polycystic Ovary Syndrome [MESH:D011085] (2186)
C20. Immune System Diseases 
C20. Immune System Diseases
 Immune System Diseases [MESH:D007154] (7674) 
 Autoimmune Diseases [MESH:D001327] (5067) 
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Hypersensitivity [MESH:D006967] (5873) 
 Drug Hypersensitivity [MESH:D004342] (4000) 
 Drug Eruptions [MESH:D003875] (2695)
 Hypersensitivity, Delayed [MESH:D006968] (3408) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Hypersensitivity, Immediate [MESH:D006969] (4980) 
 Urticaria [MESH:D014581] (2668)
 Respiratory Hypersensitivity [MESH:D012130] (4250) 
 Asthma [MESH:D001249] (3914)
 Immunologic Deficiency Syndromes [MESH:D007153] (3788) 
 Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant [MESH:C567411] (533)
 HIV Infections [MESH:D015658] (3402)
 Immunoproliferative Disorders [MESH:D007160] (4761) 
 Lymphoproliferative Disorders [MESH:D008232] (4734) 
 Multiple Myeloma [MESH:D009101] (2767)
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Lymphoma [MESH:D008223] (3684) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3330) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
 Lymphoma, T-Cell [MESH:D016399] (1382) 
 Lymphoma, T-Cell, Cutaneous [MESH:D016410] (912)
 Paraproteinemias [MESH:D010265] (2791) 
 Multiple Myeloma [MESH:D009101] (2765)
C22. Animal Diseases 
C22. Animal Diseases
 Animal Diseases [MESH:D000820] (3656) 
 Mammary Neoplasms, Animal [MESH:D015674] (2735)
C23. Pathological Conditions, Signs and Symptoms 
C23. Pathological Conditions, Signs and Symptoms
 Pathological Conditions, Anatomical [MESH:D020763] (6074) 
 Alopecia [MESH:D000505] (1383)
 Atrophy [MESH:D001284] (2603)
 Plaque, Atherosclerotic [MESH:D058226] (696)
 Hernia [MESH:D006547] (2825) 
 Hernia, Diaphragmatic [MESH:D006548] (2647)
 Hypertrophy [MESH:D006984] (4476) 
 Cardiomegaly [MESH:D006332] (3802)
 Polyps [MESH:D011127] (1633) 
 Intestinal Polyps [MESH:D007417] (1592)
 Pathologic Processes [MESH:D010335] (9863) 
 Gliosis [MESH:D005911] (1419)
 Nerve Degeneration [MESH:D009410] (4061)
 Arrhythmias, Cardiac [MESH:D001145] (4658) 
 Tachycardia [MESH:D013610] (3339) 
 Tachycardia, Ventricular [MESH:D017180] (1386) 
 Torsades de Pointes [MESH:D016171] (880)
 Chromosome Aberrations [MESH:D002869] (2352) 
 Translocation, Genetic [MESH:D014178] (557)
 Disease Attributes [MESH:D020969] (3654) 
 Disease Progression [MESH:D018450] (2868)
 Hemorrhage [MESH:D006470] (4451) 
 Shock, Hemorrhagic [MESH:D012771] (2042)
 Intracranial Hemorrhages [MESH:D020300] (3241) 
 Cerebral Hemorrhage [MESH:D002543] (2872)
 Inflammation [MESH:D007249] (5241) 
 Systemic Inflammatory Response Syndrome [MESH:D018746] (3563) 
 Sepsis [MESH:D018805] (3562)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Invasiveness [MESH:D009361] (3388)
 Neoplasm Recurrence, Local [MESH:D009364] (1949)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Neoplasm Metastasis [MESH:D009362] (4441) 
 Lymphatic Metastasis [MESH:D008207] (917)
 Postoperative Complications [MESH:D011183] (5311) 
 Pain, Postoperative [MESH:D010149] (529)
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Shock [MESH:D012769] (2550) 
 Shock, Hemorrhagic [MESH:D012771] (2042)
 Signs and Symptoms [MESH:D012816] (10659) 
 Edema [MESH:D004487] (3726)
 Flushing [MESH:D005483] (506)
 Body Weight [MESH:D001835] (4972) 
 Overweight [MESH:D050177] (4455) 
 Obesity [MESH:D009765] (4454)
 Neurologic Manifestations [MESH:D009461] (8702) 
 Sensation Disorders [MESH:D012678] (5009) 
 Hearing Disorders [MESH:D006311] (2101) 
 Hearing Loss [MESH:D034381] (2066)
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Sleep Disorders [MESH:D012893] (1301) 
 Sleep Deprivation [MESH:D012892] (233)
 Pain [MESH:D010146] (4511) 
 Pain, Postoperative [MESH:D010149] (529)
 Signs and Symptoms, Digestive [MESH:D012817] (3095) 
 Nausea [MESH:D009325] (2300)
 Vomiting [MESH:D014839] (1354)
C24. Occupational Diseases 
C24. Occupational Diseases
 Occupational Diseases [MESH:D009784] (3402)
 Z. Exceptions (1530) 
 Not Fully Specified [NFS] (1530)
C25. Chemically-Induced Disorders 
C25. Chemically-Induced Disorders
 Drug-Related Side Effects and Adverse Reactions [MESH:D064420] (5839) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Drug Hypersensitivity [MESH:D004342] (4001) 
 Drug Eruptions [MESH:D003875] (2697)
 Poisoning [MESH:D011041] (6703) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Neurotoxicity Syndromes [MESH:D020258] (3323)
 Substance-Related Disorders [MESH:D019966] (6308) 
 Amphetamine-Related Disorders [MESH:D019969] (2858)
 Cocaine-Related Disorders [MESH:D019970] (3054)
 Marijuana Abuse [MESH:D002189] (1132)
 Substance Withdrawal Syndrome [MESH:D013375] (2956)
 Alcohol-Related Disorders [MESH:D019973] (3869) 
 Alcohol-Induced Disorders [MESH:D020751] (3350) 
 Liver Diseases, Alcoholic [MESH:D008108] (3243) 
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
C26. Wounds and Injuries 
C26. Wounds and Injuries
 Z. Exceptions (2454) 
 Not Fully Specified [NFS] (2454)
 Wounds and Injuries [MESH:D014947] (5171) 
 Spinal Cord Injuries [MESH:D013119] (2688)
 Craniocerebral Trauma [MESH:D006259] (3523) 
 Brain Injuries [MESH:D001930] (3431)
 Radiation Injuries [MESH:D011832] (2718) 
 Radiation Injuries, Experimental [MESH:D011833] (2662)
 Trauma, Nervous System [MESH:D020196] (3535) 
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
D04. Polycyclic Compounds 
D04. Polycyclic Compounds
 Polycyclic Compounds [MESH:D011083] (22048) 
 Macrocyclic Compounds [MESH:D047028] (4784) 
 Peptides, Cyclic [MESH:D010456] (2157) 
 Depsipeptides [MESH:D047630] (379)
D12. Amino Acids, Peptides, and Proteins 
D12. Amino Acids, Peptides, and Proteins
 Peptides [MESH:D010455] (20561) 
 Peptides, Cyclic [MESH:D010456] (2207) 
 Depsipeptides [MESH:D047630] (379)
D27. Chemical Actions and Uses 
D27. Chemical Actions and Uses
 Pharmacologic Actions [MESH:D020228] (2566) 
 Therapeutic Uses [MESH:D045506] (1611) 
 Antineoplastic Agents [MESH:D000970] (319) 
 Antibiotics, Antineoplastic [MESH:D000903] (41)