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 pyrene
C030984
 
  
  
  

MeSH Unique Identifier: C030984
Chemical – Gene Interaction

Note 1: [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein

Note 2: [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]

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C15. Hemic and Lymphatic Diseases: Hematologic Diseases [MESH:D006402] > Blood Group Incompatibility [MESH:D001787]
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C20. Immune System Diseases: Z. Exceptions
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1. Human Genes 
1. Human Genes
 CD molecules [HGNC:CD] (1459) 
 intercellular adhesion molecule 1 [HGNC:ICAM1] (286)
 Cytochrome P450s [HGNC:CYP] (1673) 
 cytochrome P450, family 01, subfamily A, polypeptide 01 [HGNC:CYP1A1] (566)
 cytochrome P450, family 01, subfamily A, polypeptide 02 [HGNC:CYP1A2] (466)
 cytochrome P450, family 01, subfamily B, polypeptide 01 [HGNC:CYP1B1] (301)
 Endogenous Ligands [HGNC:ENDOLIG] (1191) 
 interleukin 08 [HGNC:IL8] (649)
 Heat shock proteins [HGNC:HSP] (390) 
 Heat shock proteins, HSP70 [HGNC:HSP70] (294) 
 heat shock 70kDa protein 01A [HGNC:HSPA1A] (112)
 Immunoglobulin superfamily domain containing [HGNC:IGSF] (761) 
 Immunoglobulin-like domain containing [HGNC:IGD] (645) 
 intercellular adhesion molecule 1 [HGNC:ICAM1] (286)
 Interferons and interferon receptors [HGNC:IFN] (684) 
 interferon, gamma [HGNC:IFNG] (274)
 Interleukins and interleukin receptors [HGNC:IL] (1294) 
 interleukin 04 [HGNC:IL4] (164)
 interleukin 08 [HGNC:IL8] (649)
 Tumor necrosis factor (ligand) superfamily [HGNC:TNFSF] (898) 
 tumor necrosis factor [HGNC:TNF] (795)
2. Interaction: Human Genes and Chemicals 
2. Interaction: Human Genes and Chemicals
 Affects (3990) 
 activity (338)
 binding (2423)
 cotreatment (1499)
 Decreases (5154) 
 activity (2549)
 reaction (3393)
 Increases (5571) 
 activity (2865)
 cleavage (666)
 expression (3238)
 hydroxylation (142)
 reaction (1574)
A. Anatomy 
A. Anatomy
 Body Regions [MESH:D001829] (867) 
 Head [MESH:D006257] (523) 
 Ear [MESH:D004423] (236) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Face [MESH:D005145] (387) 
 Kniest dysplasia [MESH:C537207] (89)
 Musculoskeletal System [MESH:D009141] (1255) 
 Skeleton [MESH:D012863] (1177) 
 Bone and Bones [MESH:D001842] (1112) 
 Bones of Lower Extremity [MESH:D050281] (278) 
 Leg Bones [MESH:D007867] (228) 
 Patella [MESH:D010329] (168) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Skull [MESH:D012886] (610) 
 Facial Bones [MESH:D005147] (539) 
 Jaw [MESH:D007568] (524) 
 Mandible [MESH:D008334] (511) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Sense Organs [MESH:D012679] (1060) 
 Ear [MESH:D004423] (323) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Eye [MESH:D005123] (858) 
 Anterior Eye Segment [MESH:D000869] (664) 
 Peters anomaly [MESH:C537884] (465)
 Cells [MESH:D002477] (1885) 
 Blood Cells [MESH:D001773] (196) 
 Erythrocytes [MESH:D004912] (146) 
 Erythrocytes, Abnormal [MESH:D004913] (141) 
 Erythrocyte Inclusions [MESH:D004908] (129) 
 Heinz Bodies [MESH:D006366] (128) 
 Heinz Body Anemias [MESH:C563030] (127)
 Cellular Structures [MESH:D022082] (1562) 
 Inclusion Bodies [MESH:D002479] (147) 
 Erythrocyte Inclusions [MESH:D004908] (129) 
 Heinz Bodies [MESH:D006366] (128) 
 Heinz Body Anemias [MESH:C563030] (127)
 Stomatognathic System [MESH:D013284] (673) 
 Jaw [MESH:D007568] (528) 
 Mandible [MESH:D008334] (511) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Hemic and Immune Systems [MESH:D006424] (272) 
 Blood [MESH:D001769] (200) 
 Blood Cells [MESH:D001773] (194) 
 Erythrocytes [MESH:D004912] (146) 
 Erythrocytes, Abnormal [MESH:D004913] (141) 
 Erythrocyte Inclusions [MESH:D004908] (129) 
 Heinz Bodies [MESH:D006366] (128) 
 Heinz Body Anemias [MESH:C563030] (127)
C01. Bacterial Infections and Mycoses 
C01. Bacterial Infections and Mycoses
 Bacterial Infections [MESH:D001424] (3716) 
 Gram-Negative Bacterial Infections [MESH:D016905] (3085) 
 Chlamydiaceae Infections [MESH:D002694] (1699) 
 Chlamydia Infections [MESH:D002690] (1696)
 Enterobacteriaceae Infections [MESH:D004756] (669) 
 Salmonella Infections [MESH:D012480] (620) 
 Salmonella Infections, Animal [MESH:D012481] (604)
 Legionellosis [MESH:D007876] (612) 
 Legionnaires' Disease [MESH:D007877] (611)
 Mycoplasmatales Infections [MESH:D009180] (1949) 
 Mycoplasma Infections [MESH:D009175] (1947)
 Gram-Positive Bacterial Infections [MESH:D016908] (2434) 
 Listeriosis [MESH:D008088] (1622)
 Actinomycetales Infections [MESH:D000193] (1466) 
 Mycobacterium Infections [MESH:D009164] (1446) 
 Paratuberculosis [MESH:D010283] (427)
 Tuberculosis [MESH:D014376] (992) 
 Tuberculosis, Bovine [MESH:D014380] (380)
 Sexually Transmitted Diseases, Bacterial [MESH:D015231] (1711) 
 Chlamydia Infections [MESH:D002690] (1693)
 Infection [MESH:D007239] (4109) 
 Arthritis, Infectious [MESH:D001170] (1702)
 Intraabdominal Infections [MESH:D059413] (958) 
 Appendicitis [MESH:D001064] (774)
 Peritonitis [MESH:D010538] (800)
 Sepsis [MESH:D018805] (3556) 
 Shock, Septic [MESH:D012772] (1830)
 Sexually Transmitted Diseases [MESH:D012749] (1712) 
 Sexually Transmitted Diseases, Bacterial [MESH:D015231] (1711) 
 Chlamydia Infections [MESH:D002690] (1693)
C02. Virus Diseases 
C02. Virus Diseases
 Virus Diseases [MESH:D014777] (4544) 
 Central Nervous System Viral Diseases [MESH:D020805] (1416) 
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 DNA Virus Infections [MESH:D004266] (2474) 
 Hepadnaviridae Infections [MESH:D018347] (977) 
 Hepatitis B [MESH:D006509] (976)
 Hepatitis, Viral, Human [MESH:D006525] (1766) 
 Hepatitis B [MESH:D006509] (976)
 Hepatitis C [MESH:D006526] (1627)
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 RNA Virus Infections [MESH:D012327] (4215) 
 Flaviviridae Infections [MESH:D018178] (1656) 
 Hepatitis C [MESH:D006526] (1627)
 Mononegavirales Infections [MESH:D018701] (900) 
 Paramyxoviridae Infections [MESH:D018184] (889) 
 Pneumovirus Infections [MESH:D018186] (853) 
 Respiratory Syncytial Virus Infections [MESH:D018357] (852)
 Picornaviridae Infections [MESH:D010850] (1672) 
 Cardiovirus Infections [MESH:D018188] (1548)
 Retroviridae Infections [MESH:D012192] (3420) 
 Lentivirus Infections [MESH:D016180] (3408) 
 HIV Infections [MESH:D015658] (3402) 
 Acquired Immunodeficiency Syndrome [MESH:D000163] (743)
 HIV Seropositivity [MESH:D006679] (480)
 HIV Wasting Syndrome [MESH:D019247] (1956)
 Sexually Transmitted Diseases [MESH:D012749] (3305) 
 Sexually Transmitted Diseases, Viral [MESH:D015229] (3304) 
 HIV Infections [MESH:D015658] (3296) 
 Acquired Immunodeficiency Syndrome [MESH:D000163] (743)
 HIV Seropositivity [MESH:D006679] (480)
 HIV Wasting Syndrome [MESH:D019247] (1956)
 Slow Virus Diseases [MESH:D012897] (782) 
 Acquired Immunodeficiency Syndrome [MESH:D000163] (743)
C03. Parasitic Diseases 
C03. Parasitic Diseases
 Parasitic Diseases [MESH:D010272] (3828) 
 Helminthiasis [MESH:D006373] (1644) 
 Nematode Infections [MESH:D009349] (870) 
 Adenophorea Infections [MESH:D017188] (808) 
 Enoplida Infections [MESH:D017189] (807) 
 Trichuriasis [MESH:D014257] (805)
 Protozoan Infections [MESH:D011528] (3014) 
 Amebiasis [MESH:D000562] (1711) 
 Entamoebiasis [MESH:D004749] (1689)
 Euglenozoa Infections [MESH:D056986] (2552) 
 Leishmaniasis [MESH:D007896] (2541) 
 Leishmaniasis, Visceral [MESH:D007898] (2149)
 Leishmaniasis, Cutaneous [MESH:D016773] (2359) 
 Leishmaniasis, Mucocutaneous [MESH:D007897] (606)
 Malaria [MESH:D008288] (2175) 
 Malaria, Falciparum [MESH:D016778] (438)
 Skin Diseases, Parasitic [MESH:D012876] (2541) 
 Leishmaniasis [MESH:D007896] (2516) 
 Leishmaniasis, Cutaneous [MESH:D016773] (2359) 
 Leishmaniasis, Mucocutaneous [MESH:D007897] (606)
C04. Neoplasms 
C04. Neoplasms
 Neoplasms [MESH:D009369] (10293) 
 Precancerous Conditions [MESH:D011230] (2858)
 Hamartoma [MESH:D006222] (1484) 
 Tuberous Sclerosis [MESH:D014402] (635)
 Neoplasms by Histologic Type [MESH:D009370] (8793) 
 Leukemia [MESH:D007938] (4576) 
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Leukemia, Myeloid [MESH:D007951] (2773) 
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive [MESH:D015464] (1032)
 Leukemia, Myeloid, Acute [MESH:D015470] (2176) 
 Leukemia, Promyelocytic, Acute [MESH:D015473] (1367)
 Lymphoma [MESH:D008223] (3686) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3337) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
 Neoplasms, Complex and Mixed [MESH:D018193] (1121) 
 Hepatoblastoma [MESH:D018197] (548)
 Neoplasms, Connective and Soft Tissue [MESH:D018204] (4742) 
 Neoplasms, Connective Tissue [MESH:D009372] (3626) 
 Chondrosarcoma [MESH:D002813] (1217)
 Neoplasms, Bone Tissue [MESH:D018213] (2217) 
 Osteosarcoma [MESH:D012516] (2175)
 Neoplasms, Fibrous Tissue [MESH:D018218] (1720) 
 Fibroma [MESH:D005350] (1578) 
 Fibromatosis, Aggressive [MESH:D018222] (1562)
 Histiocytoma [MESH:D051642] (272) 
 Histiocytoma, Malignant Fibrous [MESH:D051677] (266) 
 Histiocytoma, Angiomatoid Fibrous [MESH:C563181] (258)
 Neoplasms, Muscle Tissue [MESH:D009379] (1965) 
 Smooth Muscle Tumor [MESH:D018235] (132)
 Sarcoma [MESH:D012509] (4246) 
 Chondrosarcoma [MESH:D002813] (1217)
 Hemangiosarcoma [MESH:D006394] (1836)
 Osteosarcoma [MESH:D012516] (2175)
 Histiocytoma, Malignant Fibrous [MESH:D051677] (266) 
 Histiocytoma, Angiomatoid Fibrous [MESH:C563181] (258)
 Neoplasms, Germ Cell and Embryonal [MESH:D009373] (5126) 
 Neuroectodermal Tumors [MESH:D017599] (5066) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neuroendocrine Tumors [MESH:D018358] (3633) 
 Melanoma [MESH:D008545] (3508)
 Neoplasms, Glandular and Epithelial [MESH:D009375] (7760) 
 Adenoma [MESH:D000236] (4051) 
 Mesothelioma [MESH:D008654] (2567)
 Carcinoma [MESH:D002277] (7263) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Small Cell [MESH:D018288] (1317)
 Carcinoma, Transitional Cell [MESH:D002295] (2662)
 Adenocarcinoma [MESH:D000230] (6565) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Carcinoma, Adenoid Cystic [MESH:D003528] (1561)
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Cholangiocarcinoma [MESH:D018281] (2398)
 Carcinoma, Ductal [MESH:D044584] (1786) 
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Carcinoma in Situ [MESH:D002278] (2111) 
 Prostatic Intraepithelial Neoplasia [MESH:D019048] (1565)
 Carcinoma, Squamous Cell [MESH:D002294] (4294) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Neoplasms, Ductal, Lobular, and Medullary [MESH:D018299] (1831) 
 Carcinoma, Ductal [MESH:D044584] (1786) 
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Neoplasms, Mesothelial [MESH:D018301] (2569) 
 Mesothelioma [MESH:D008654] (2567)
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neoplasms, Squamous Cell [MESH:D018307] (4457) 
 Papilloma [MESH:D010212] (2243)
 Carcinoma, Squamous Cell [MESH:D002294] (4294) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Neoplasms, Nerve Tissue [MESH:D009380] (5201) 
 Nerve Sheath Neoplasms [MESH:D018317] (365)
 Neuroectodermal Tumors [MESH:D017599] (5059) 
 Neoplasms, Neuroepithelial [MESH:D018302] (4487) 
 Glioma [MESH:D005910] (4261) 
 Astrocytoma [MESH:D001254] (2692) 
 Glioblastoma [MESH:D005909] (2554)
 Neuroectodermal Tumors, Primitive [MESH:D018242] (2005) 
 Neuroectodermal Tumors, Primitive, Peripheral [MESH:D018241] (1433) 
 Neuroblastoma [MESH:D009447] (1420)
 Neuroendocrine Tumors [MESH:D018358] (3625) 
 Melanoma [MESH:D008545] (3508)
 Neoplasms, Plasma Cell [MESH:D054219] (2772) 
 Multiple Myeloma [MESH:D009101] (2767)
 Neoplasms, Vascular Tissue [MESH:D009383] (2959) 
 Hemangiosarcoma [MESH:D006394] (1836)
 Hemangioma [MESH:D006391] (690) 
 Hemangioma, Capillary [MESH:D018324] (503) 
 Hemangioblastoma [MESH:D018325] (395)
 Nevi and Melanomas [MESH:D018326] (3572) 
 Melanoma [MESH:D008545] (3508)
 Neoplasms by Site [MESH:D009371] (9169) 
 Bone Neoplasms [MESH:D001859] (1334)
 Skin Neoplasms [MESH:D012878] (2992)
 Soft Tissue Neoplasms [MESH:D012983] (2003)
 Breast Neoplasms [MESH:D001943] (6077) 
 Breast Neoplasms, Male [MESH:D018567] (650)
 Digestive System Neoplasms [MESH:D004067] (7487) 
 Gastrointestinal Neoplasms [MESH:D005770] (6452) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5358) 
 Cecal Neoplasms [MESH:D002430] (822)
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Ovarian Neoplasms [MESH:D010051] (3275)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Head and Neck Neoplasms [MESH:D006258] (4612) 
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Mouth Neoplasms [MESH:D009062] (2263) 
 Tongue Neoplasms [MESH:D014062] (1518)
 Mammary Neoplasms, Animal [MESH:D015674] (3404) 
 Mammary Neoplasms, Experimental [MESH:D008325] (3268)
 Nervous System Neoplasms [MESH:D009423] (3130) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Thoracic Neoplasms [MESH:D013899] (6032) 
 Thymus Neoplasms [MESH:D013953] (247)
 Respiratory Tract Neoplasms [MESH:D012142] (6020) 
 Lung Neoplasms [MESH:D008175] (6015) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
 Urogenital Neoplasms [MESH:D014565] (7002) 
 Genital Neoplasms, Female [MESH:D005833] (2540) 
 Uterine Neoplasms [MESH:D014594] (2431) 
 Endometrial Neoplasms [MESH:D016889] (1987)
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Neoplasms, Experimental [MESH:D009374] (5218) 
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Mammary Neoplasms, Experimental [MESH:D008325] (3268)
 Neoplasms, Multiple Primary [MESH:D009378] (961) 
 Tuberous Sclerosis [MESH:D014402] (635)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Invasiveness [MESH:D009361] (3388)
 Neoplasm Metastasis [MESH:D009362] (4441)
 Neoplasm Recurrence, Local [MESH:D009364] (1949)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Neoplastic Syndromes, Hereditary [MESH:D009386] (2578) 
 Tuberous Sclerosis [MESH:D014402] (635)
C05. Musculoskeletal Diseases 
C05. Musculoskeletal Diseases
 Musculoskeletal Diseases [MESH:D009140] (8705) 
 Bone Diseases [MESH:D001847] (5801) 
 Bone Neoplasms [MESH:D001859] (1334)
 Bone Diseases, Developmental [MESH:D001848] (3315) 
 Marfan Syndrome [MESH:D008382] (646)
 Acro-Osteolysis [MESH:D030981] (548) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Dwarfism [MESH:D004392] (778) 
 Kniest dysplasia [MESH:C537207] (89)
 Achondroplasia [MESH:D000130] (196) 
 Achondrogenesis type 2 [MESH:C536017] (89)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
 Osteochondrodysplasias [MESH:D010009] (2440) 
 Spondyloepiphyseal dysplasia, congenita [MESH:C535788] (89)
 Spondylometaphyseal dysplasia, Kozlowski type [MESH:C535797] (118)
 Kniest dysplasia [MESH:C537207] (89)
 Strudwick syndrome [MESH:C537501] (89)
 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness [MESH:C565046] (89)
 Osteoarthritis with Mild Chondrodysplasia [MESH:C565740] (89)
 Spondyloepimetaphyseal Dysplasia, Missouri Type [MESH:C566574] (142)
 Metaphyseal Anadysplasia 2 [MESH:C567771] (452)
 Achondroplasia [MESH:D000130] (196) 
 Achondrogenesis type 2 [MESH:C536017] (89)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
 Bone Diseases, Metabolic [MESH:D001851] (3492) 
 Osteoporosis [MESH:D010024] (3037) 
 Osteoporosis, Postmenopausal [MESH:D015663] (2351)
 Bone Resorption [MESH:D001862] (2352) 
 Osteolysis [MESH:D010014] (1787) 
 Acro-Osteolysis [MESH:D030981] (548) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Osteonecrosis [MESH:D010020] (539) 
 Femur Head Necrosis [MESH:D005271] (268) 
 Legg-Calve-Perthes Disease [MESH:D007873] (90)
 Spinal Diseases [MESH:D013122] (2485) 
 Intervertebral Disc Degeneration [MESH:D055959] (827) 
 Intervertebral disc disease [MESH:C535531] (514)
 Intervertebral Disc Displacement [MESH:D007405] (520) 
 Intervertebral disc disease [MESH:C535531] (514)
 Spinal Curvatures [MESH:D013121] (742) 
 Kyphosis [MESH:D007738] (637)
 Spondylitis [MESH:D013166] (1924) 
 Spondylarthritis [MESH:D025241] (1912) 
 Spondylarthropathies [MESH:D025242] (1909) 
 Arthritis, Psoriatic [MESH:D015535] (1859)
 Spondylitis, Ankylosing [MESH:D013167] (431)
 Jaw Diseases [MESH:D007571] (1601) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Joint Diseases [MESH:D007592] (4657) 
 Ankylosis [MESH:D000844] (479) 
 Spondylitis, Ankylosing [MESH:D013167] (431)
 Arthritis [MESH:D001168] (4416) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Arthritis, Experimental [MESH:D001169] (3142)
 Arthritis, Infectious [MESH:D001170] (1702)
 Arthritis, Psoriatic [MESH:D015535] (1859)
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Osteoarthritis [MESH:D010003] (1743) 
 Osteoarthritis with Mild Chondrodysplasia [MESH:C565740] (89)
 Spondylarthritis [MESH:D025241] (1912) 
 Spondylarthropathies [MESH:D025242] (1909) 
 Arthritis, Psoriatic [MESH:D015535] (1859)
 Spondylitis, Ankylosing [MESH:D013167] (431)
 Muscular Diseases [MESH:D009135] (4071) 
 Mitochondrial Myopathies [MESH:D017240] (2176) 
 Mitochondrial Encephalomyopathies [MESH:D017237] (1121) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Myositis [MESH:D009220] (2071) 
 Dermatomyositis [MESH:D003882] (1826)
 Polymyositis [MESH:D017285] (2007) 
 Dermatomyositis [MESH:D003882] (1826)
 Musculoskeletal Abnormalities [MESH:D009139] (3796) 
 Craniofacial Abnormalities [MESH:D019465] (3098) 
 Macrocephaly [MESH:D058627] (264) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Microcephaly [MESH:D008831] (700) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Limb Deformities, Congenital [MESH:D017880] (1813) 
 Metaphyseal Anadysplasia 2 [MESH:C567771] (452)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
 Rheumatic Diseases [MESH:D012216] (4032) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Osteoarthritis [MESH:D010003] (1743) 
 Osteoarthritis with Mild Chondrodysplasia [MESH:C565740] (89)
C06. Digestive System Diseases 
C06. Digestive System Diseases
 Digestive System Diseases [MESH:D004066] (9461) 
 Biliary Tract Diseases [MESH:D001660] (3845) 
 Bile Duct Diseases [MESH:D001649] (3512) 
 Cholestasis [MESH:D002779] (3419) 
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Digestive System Abnormalities [MESH:D004065] (2127) 
 Barrett Esophagus [MESH:D001471] (1930)
 Digestive System Neoplasms [MESH:D004067] (7493) 
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Cecal Neoplasms [MESH:D002430] (822)
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Gastrointestinal Diseases [MESH:D005767] (7443) 
 Esophageal Diseases [MESH:D004935] (4255) 
 Barrett Esophagus [MESH:D001471] (1930)
 Deglutition Disorders [MESH:D003680] (1538) 
 Esophageal Motility Disorders [MESH:D015154] (1489) 
 Gastroesophageal Reflux [MESH:D005764] (1465)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Esophagitis [MESH:D004941] (1120) 
 Esophagitis, Peptic [MESH:D004942] (709)
 Gastroenteritis [MESH:D005759] (4066) 
 Appendicitis [MESH:D001064] (774)
 Colitis [MESH:D003092] (3199) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Esophagitis [MESH:D004941] (1120) 
 Esophagitis, Peptic [MESH:D004942] (709)
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Crohn Disease [MESH:D003424] (2585)
 Gastrointestinal Hemorrhage [MESH:D006471] (815) 
 Peptic Ulcer Hemorrhage [MESH:D010438] (553)
 Gastrointestinal Neoplasms [MESH:D005770] (6460) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Esophageal Neoplasms [MESH:D004938] (3737) 
 Esophageal Squamous Cell Carcinoma [MESH:C562729] (2396)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Cecal Neoplasms [MESH:D002430] (822)
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Intestinal Diseases [MESH:D007410] (6206) 
 Cecal Diseases [MESH:D002429] (1330) 
 Appendicitis [MESH:D001064] (774)
 Cecal Neoplasms [MESH:D002430] (822)
 Colonic Diseases [MESH:D003108] (5564) 
 Colitis [MESH:D003092] (3199) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Colorectal Neoplasms [MESH:D015179] (5282) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Inflammatory Bowel Diseases [MESH:D015212] (3492) 
 Colitis, Ulcerative [MESH:D003093] (2601)
 Crohn Disease [MESH:D003424] (2585)
 Intestinal Neoplasms [MESH:D007414] (5359) 
 Cecal Neoplasms [MESH:D002430] (822)
 Colorectal Neoplasms [MESH:D015179] (5294) 
 Colonic Neoplasms [MESH:D003110] (4405)
 Intestinal Obstruction [MESH:D007415] (146) 
 Ileus [MESH:D045823] (128) 
 Intestinal Pseudo-Obstruction [MESH:D007418] (118) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Rectal Diseases [MESH:D012002] (4596) 
 Colorectal Neoplasms [MESH:D015179] (4534)
 Peptic Ulcer [MESH:D010437] (3172) 
 Esophagitis, Peptic [MESH:D004942] (709)
 Stomach Ulcer [MESH:D013276] (2915)
 Stomach Diseases [MESH:D013272] (5325) 
 Stomach Neoplasms [MESH:D013274] (4942)
 Peptic Ulcer [MESH:D010437] (2994) 
 Stomach Ulcer [MESH:D013276] (2915)
 Liver Diseases [MESH:D008107] (8167) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Hepatomegaly [MESH:D006529] (1169)
 Cholestasis, Intrahepatic [MESH:D002780] (1510) 
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Fatty Liver [MESH:D005234] (3584) 
 Non-alcoholic Fatty Liver Disease [MESH:C541083] (1567)
 Hepatic Insufficiency [MESH:D048550] (2771) 
 Liver Failure [MESH:D017093] (2768) 
 Hepatic Encephalopathy [MESH:D006501] (1795)
 Liver Failure, Acute [MESH:D017114] (2404)
 Hepatitis [MESH:D006505] (3883) 
 Hepatitis, Alcoholic [MESH:D006519] (1613)
 Hepatitis, Chronic [MESH:D006521] (2071) 
 Hepatitis, Autoimmune [MESH:D019693] (1982)
 Hepatitis, Viral, Human [MESH:D006525] (1766) 
 Hepatitis B [MESH:D006509] (976)
 Hepatitis C [MESH:D006526] (1627)
 Liver Cirrhosis [MESH:D008103] (5542) 
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
 Liver Cirrhosis, Biliary [MESH:D008105] (1274)
 Liver Cirrhosis, Experimental [MESH:D008106] (4589)
 Liver Diseases, Alcoholic [MESH:D008108] (3243) 
 Hepatitis, Alcoholic [MESH:D006519] (1613)
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
 Liver Neoplasms [MESH:D008113] (6048) 
 Carcinoma, Hepatocellular [MESH:D006528] (5375)
 Liver Neoplasms, Experimental [MESH:D008114] (2837)
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Pancreatic Diseases [MESH:D010182] (4453) 
 Pancreatitis [MESH:D010195] (1924)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Peritoneal Diseases [MESH:D010532] (1119) 
 Peritonitis [MESH:D010538] (800)
C07. Stomatognathic Diseases 
C07. Stomatognathic Diseases
 Stomatognathic Diseases [MESH:D009057] (5348) 
 Jaw Diseases [MESH:D007571] (1608) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Mouth Diseases [MESH:D009059] (4783) 
 Behcet Syndrome [MESH:D001528] (1784)
 Oral Submucous Fibrosis [MESH:D009914] (2432)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Mouth Neoplasms [MESH:D009062] (2263) 
 Tongue Neoplasms [MESH:D014062] (1518)
 Periodontal Diseases [MESH:D010510] (1001) 
 Periodontitis [MESH:D010518] (843)
 Stomatitis [MESH:D013280] (1235) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Tongue Diseases [MESH:D014060] (1544) 
 Tongue Neoplasms [MESH:D014062] (1518)
 Stomatognathic System Abnormalities [MESH:D018640] (1705) 
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
C08. Respiratory Tract Diseases 
C08. Respiratory Tract Diseases
 Z. Exceptions (1984) 
 Not Fully Specified [NFS] (1984)
 Respiratory Tract Diseases [MESH:D012140] (7881) 
 Bronchial Diseases [MESH:D001982] (4382) 
 Asthma [MESH:D001249] (4098)
 Bronchial Hyperreactivity [MESH:D016535] (1357)
 Bronchiectasis [MESH:D001987] (1792)
 Bronchitis [MESH:D001991] (993) 
 Bronchiolitis [MESH:D001988] (617) 
 Bronchiolitis Obliterans [MESH:D001989] (611)
 Lung Diseases [MESH:D008171] (7249) 
 Hypertension, Pulmonary [MESH:D006976] (2000)
 Pneumonia [MESH:D011014] (3482)
 Pulmonary Edema [MESH:D011654] (2109)
 Pulmonary Embolism [MESH:D011655] (1118)
 Pulmonary Fibrosis [MESH:D011658] (3140)
 Respiratory Distress Syndrome, Adult [MESH:D012128] (864)
 Lung Diseases, Interstitial [MESH:D017563] (2966) 
 Pneumoconiosis [MESH:D011009] (2789) 
 Anthracosis [MESH:D055008] (1805)
 Berylliosis [MESH:D001607] (2005)
 Silicosis [MESH:D012829] (1273)
 Lung Diseases, Obstructive [MESH:D008173] (4697) 
 Asthma [MESH:D001249] (3903)
 Pulmonary Disease, Chronic Obstructive [MESH:D029424] (3564)
 Bronchitis [MESH:D001991] (993) 
 Bronchiolitis [MESH:D001988] (617) 
 Bronchiolitis Obliterans [MESH:D001989] (611)
 Lung Injury [MESH:D055370] (3688) 
 Acute Lung Injury [MESH:D055371] (1907)
 Pneumoconiosis [MESH:D011009] (2789) 
 Anthracosis [MESH:D055008] (1805)
 Berylliosis [MESH:D001607] (2005)
 Silicosis [MESH:D012829] (1273)
 Lung Neoplasms [MESH:D008175] (6012) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
 Respiratory Distress Syndrome, Newborn [MESH:D012127] (169) 
 Hyaline Membrane Disease [MESH:D006819] (93) 
 Kniest dysplasia [MESH:C537207] (89)
 Nose Diseases [MESH:D009668] (1504) 
 Rhinitis [MESH:D012220] (1134) 
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Pleural Diseases [MESH:D010995] (2240) 
 Pleurisy [MESH:D010998] (2070)
 Respiration Disorders [MESH:D012120] (2218) 
 Hyperventilation [MESH:D006985] (654)
 Respiratory Distress Syndrome, Adult [MESH:D012128] (864)
 Respiratory Distress Syndrome, Newborn [MESH:D012127] (169) 
 Hyaline Membrane Disease [MESH:D006819] (93) 
 Kniest dysplasia [MESH:C537207] (89)
 Respiratory Hypersensitivity [MESH:D012130] (4401) 
 Asthma [MESH:D001249] (4098)
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Respiratory Tract Infections [MESH:D012141] (3926) 
 Pleurisy [MESH:D010998] (2070)
 Pneumonia [MESH:D011014] (3482)
 Rhinitis [MESH:D012220] (766)
 Legionellosis [MESH:D007876] (612) 
 Legionnaires' Disease [MESH:D007877] (611)
 Respiratory Tract Neoplasms [MESH:D012142] (6053) 
 Lung Neoplasms [MESH:D008175] (6013) 
 Adenocarcinoma of lung [MESH:C538231] (1487)
 Bronchial Neoplasms [MESH:D001984] (3608) 
 Carcinoma, Bronchogenic [MESH:D002283] (3606) 
 Carcinoma, Non-Small-Cell Lung [MESH:D002289] (3540)
 Small Cell Lung Carcinoma [MESH:D055752] (1380)
C09. Otorhinolaryngologic Diseases 
C09. Otorhinolaryngologic Diseases
 Otorhinolaryngologic Diseases [MESH:D010038] (3827) 
 Ear Diseases [MESH:D004427] (2522) 
 Hearing Disorders [MESH:D006311] (2103) 
 Hearing Loss [MESH:D034381] (2068) 
 Hearing Loss, Conductive [MESH:D006314] (134) 
 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness [MESH:C565046] (89)
 Hearing Loss, Sensorineural [MESH:D006319] (1227) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Deafness, Autosomal Dominant 20 [MESH:C565754] (69)
 Labyrinth Diseases [MESH:D007759] (846) 
 Vestibular Diseases [MESH:D015837] (819)
 Nose Diseases [MESH:D009668] (1504) 
 Rhinitis [MESH:D012220] (1134) 
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
C10. Nervous System Diseases 
C10. Nervous System Diseases
 Z. Exceptions (4027) 
 Not Fully Specified [NFS] (4027)
 Nervous System Diseases [MESH:D009422] (13325) 
 Chronobiology Disorders [MESH:D021081] (970)
 Restless Legs Syndrome [MESH:D012148] (379)
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Central Nervous System Diseases [MESH:D002493] (9745) 
 Brain Diseases [MESH:D001927] (9294) 
 Brain Edema [MESH:D001929] (1165)
 Brain Injuries [MESH:D001930] (3429)
 Brain Neoplasms [MESH:D001932] (2764)
 Basal Ganglia Diseases [MESH:D001480] (4268) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Huntington Disease [MESH:D006816] (540)
 Parkinsonian Disorders [MESH:D020734] (4009) 
 Parkinson Disease [MESH:D010300] (3595)
 Brain Diseases, Metabolic [MESH:D001928] (3351) 
 Hepatic Encephalopathy [MESH:D006501] (1795)
 Kernicterus [MESH:D007647] (256)
 Brain Diseases, Metabolic, Inborn [MESH:D020739] (2634) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Peroxisomal Disorders [MESH:D018901] (1472) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Mitochondrial Encephalomyopathies [MESH:D017237] (158) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Cerebrovascular Disorders [MESH:D002561] (5542) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Brain Ischemia [MESH:D002545] (4873) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2463) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Hemorrhages [MESH:D020300] (3269) 
 Cerebral Hemorrhage [MESH:D002543] (2873)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Dementia [MESH:D003704] (4498) 
 Alzheimer Disease [MESH:D000544] (4275)
 Huntington Disease [MESH:D006816] (540)
 Epilepsy [MESH:D004827] (6274) 
 Seizures [MESH:D012640] (4502)
 Status Epilepticus [MESH:D013226] (4014)
 Epilepsies, Partial [MESH:D004828] (1267) 
 Epilepsy, Temporal Lobe [MESH:D004833] (1108)
 Headache Disorders [MESH:D020773] (2337) 
 Headache Disorders, Primary [MESH:D051270] (2327) 
 Migraine Disorders [MESH:D008881] (2318)
 Leukoencephalopathies [MESH:D056784] (1916) 
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Central Nervous System Infections [MESH:D002494] (1823) 
 Central Nervous System Viral Diseases [MESH:D020805] (1416) 
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Meningitis [MESH:D008581] (1506) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Meningitis, Viral [MESH:D008587] (1308) 
 Meningitis, Aseptic [MESH:D008582] (1305)
 Movement Disorders [MESH:D009069] (4823) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Dyskinesias [MESH:D020820] (1827) 
 Dyskinesia, Drug-Induced [MESH:D004409] (1389)
 Chorea [MESH:D002819] (651) 
 Huntington Disease [MESH:D006816] (540)
 Parkinsonian Disorders [MESH:D020734] (4009) 
 Parkinson Disease [MESH:D010300] (3595)
 Spinal Cord Diseases [MESH:D013118] (4376) 
 Spinal Cord Compression [MESH:D013117] (1800)
 Spinal Cord Injuries [MESH:D013119] (1674)
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Muscular Atrophy, Spinal [MESH:D009134] (850) 
 Bulbo-Spinal Atrophy, X-Linked [MESH:D055534] (566) 
 Bulbospinal neuronopathy, X-linked recessive [MESH:C537017] (565)
 Cranial Nerve Diseases [MESH:D003389] (2004) 
 Optic Nerve Diseases [MESH:D009901] (1375) 
 Optic Atrophy [MESH:D009896] (1203) 
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Demyelinating Diseases [MESH:D003711] (2917) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (2035) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Hereditary Sensory and Motor Neuropathy [MESH:D015417] (899) 
 Charcot-Marie-Tooth Disease [MESH:D002607] (627) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Malformations of Cortical Development [MESH:D054220] (1406) 
 Neuronal Migration Disorders [MESH:D054081] (264)
 Tuberous Sclerosis [MESH:D014402] (635)
 Macrocephaly [MESH:D058627] (264) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Microcephaly [MESH:D008831] (700) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Nervous System Neoplasms [MESH:D009423] (3073) 
 Central Nervous System Neoplasms [MESH:D016543] (3055) 
 Brain Neoplasms [MESH:D001932] (2764)
 Peripheral Nervous System Neoplasms [MESH:D010524] (287) 
 Nerve Sheath Neoplasms [MESH:D018317] (286)
 Neurocutaneous Syndromes [MESH:D020752] (1230) 
 Tuberous Sclerosis [MESH:D014402] (635)
 Neurodegenerative Diseases [MESH:D019636] (6613) 
 Parkinson Disease [MESH:D010300] (3595)
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3243) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Huntington Disease [MESH:D006816] (540)
 Tuberous Sclerosis [MESH:D014402] (635)
 Bulbo-Spinal Atrophy, X-Linked [MESH:D055534] (566) 
 Bulbospinal neuronopathy, X-linked recessive [MESH:C537017] (565)
 Hereditary Sensory and Motor Neuropathy [MESH:D015417] (899) 
 Charcot-Marie-Tooth Disease [MESH:D002607] (627) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Muscular Atrophy, Spinal [MESH:D009134] (850) 
 Bulbo-Spinal Atrophy, X-Linked [MESH:D055534] (566) 
 Bulbospinal neuronopathy, X-linked recessive [MESH:C537017] (565)
 Tauopathies [MESH:D024801] (4289) 
 Alzheimer Disease [MESH:D000544] (4275)
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Neurologic Manifestations [MESH:D009461] (8964) 
 Neurogenic Inflammation [MESH:D020078] (2246)
 Seizures [MESH:D012640] (4514)
 Neurobehavioral Manifestations [MESH:D019954] (5230) 
 Memory Disorders [MESH:D008569] (3233)
 Communication Disorders [MESH:D003147] (2918) 
 Learning Disorders [MESH:D007859] (2727)
 Intellectual Disability [MESH:D008607] (3054) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Mental Retardation, Autosomal Recessive 7 [MESH:C567016] (29)
 Down Syndrome [MESH:D004314] (1287)
 Mental Retardation, X-Linked [MESH:D038901] (1854) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Pain [MESH:D010146] (3875) 
 Pain, Intractable [MESH:D010148] (707)
 Neuralgia [MESH:D009437] (2074) 
 Neuralgia, Postherpetic [MESH:D051474] (742)
 Sensation Disorders [MESH:D012678] (5011) 
 Hearing Disorders [MESH:D006311] (2103) 
 Hearing Loss [MESH:D034381] (2068) 
 Hearing Loss, Conductive [MESH:D006314] (134) 
 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness [MESH:C565046] (89)
 Hearing Loss, Sensorineural [MESH:D006319] (1227) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Deafness, Autosomal Dominant 20 [MESH:C565754] (69)
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Neuromuscular Diseases [MESH:D009468] (7336) 
 Motor Neuron Disease [MESH:D016472] (3670) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Muscular Atrophy, Spinal [MESH:D009134] (850) 
 Bulbo-Spinal Atrophy, X-Linked [MESH:D055534] (566) 
 Bulbospinal neuronopathy, X-linked recessive [MESH:C537017] (565)
 Muscular Diseases [MESH:D009135] (3538) 
 Mitochondrial Myopathies [MESH:D017240] (2176) 
 Mitochondrial Encephalomyopathies [MESH:D017237] (1121) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Myositis [MESH:D009220] (2069) 
 Dermatomyositis [MESH:D003882] (1826)
 Polymyositis [MESH:D017285] (2007) 
 Dermatomyositis [MESH:D003882] (1826)
 Peripheral Nervous System Diseases [MESH:D010523] (6151) 
 Diabetic Neuropathies [MESH:D003929] (2442)
 Neuralgia [MESH:D009437] (2078) 
 Neuralgia, Postherpetic [MESH:D051474] (742)
 Peripheral Nervous System Neoplasms [MESH:D010524] (287) 
 Nerve Sheath Neoplasms [MESH:D018317] (286)
 Polyneuropathies [MESH:D011115] (1134) 
 Hereditary Sensory and Motor Neuropathy [MESH:D015417] (899) 
 Charcot-Marie-Tooth Disease [MESH:D002607] (627) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Neurotoxicity Syndromes [MESH:D020258] (4570) 
 Dyskinesia, Drug-Induced [MESH:D004409] (1389)
 Heavy Metal Poisoning, Nervous System [MESH:D020260] (2912) 
 Arsenic Poisoning [MESH:D020261] (2540)
 Manganese Poisoning [MESH:D020149] (2214)
 Sleep Disorders [MESH:D012893] (2050) 
 Dyssomnias [MESH:D020920] (1417) 
 Sleep Disorders, Intrinsic [MESH:D020919] (1270) 
 Restless Legs Syndrome [MESH:D012148] (379)
 Parasomnias [MESH:D020447] (453) 
 Restless Legs Syndrome [MESH:D012148] (379)
 Trauma, Nervous System [MESH:D020196] (3997) 
 Spinal Cord Injuries [MESH:D013119] (1676)
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
C11. Eye Diseases 
C11. Eye Diseases
 Eye Diseases [MESH:D005128] (6245) 
 Eyelid Diseases [MESH:D005141] (882)
 Corneal Diseases [MESH:D003316] (1445) 
 Corneal Opacity [MESH:D003318] (544) 
 Peters anomaly [MESH:C537884] (465)
 Eye Abnormalities [MESH:D005124] (1233) 
 Peters anomaly [MESH:C537884] (465)
 Coloboma [MESH:D003103] (315)
 Eye Diseases, Hereditary [MESH:D015785] (1869) 
 Stickler Syndrome, Type I, Nonsyndromic Ocular [MESH:C563709] (89)
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Lens Diseases [MESH:D007905] (900) 
 Cataract [MESH:D002386] (860)
 Ocular Hypertension [MESH:D009798] (1630) 
 Glaucoma [MESH:D005901] (1458) 
 Glaucoma 3, Primary Congenital, A [MESH:C565547] (434)
 Glaucoma, Open-Angle [MESH:D005902] (1281) 
 Glaucoma, Primary Open Angle [MESH:C562750] (466)
 Glaucoma 1, Open Angle, A [MESH:C564234] (446)
 Optic Nerve Diseases [MESH:D009901] (1377) 
 Optic Atrophy [MESH:D009896] (1203) 
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Refractive Errors [MESH:D012030] (457) 
 Myopia [MESH:D009216] (349) 
 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness [MESH:C565046] (89)
 Retinal Diseases [MESH:D012164] (3747) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Retinal Degeneration [MESH:D012162] (2386) 
 Hyaloideoretinal degeneration of Wagner [MESH:C536075] (135)
 Retinal Detachment [MESH:D012163] (1639) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Uveal Diseases [MESH:D014603] (2428) 
 Uveitis [MESH:D014605] (2157) 
 Panuveitis [MESH:D015864] (1805) 
 Uveitis, Anterior [MESH:D014606] (1791) 
 Behcet Syndrome [MESH:D001528] (1784)
C12. Male Urogenital Diseases 
C12. Male Urogenital Diseases
 Male Urogenital Diseases [MESH:D052801] (8891) 
 Genital Diseases, Male [MESH:D005832] (6794) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Infertility [MESH:D007246] (2909) 
 Infertility, Male [MESH:D007248] (2851)
 Penile Diseases [MESH:D010409] (1805) 
 Hypospadias [MESH:D007021] (798) 
 Hypospadias 1, X-Linked [MESH:C567482] (571)
 Prostatic Diseases [MESH:D011469] (6204) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Sexually Transmitted Diseases [MESH:D012749] (1712) 
 Sexually Transmitted Diseases, Bacterial [MESH:D015231] (1711) 
 Chlamydia Infections [MESH:D002690] (1693)
 Urogenital Abnormalities [MESH:D014564] (2065) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XY Disorders of Sex Development [MESH:D058490] (1060) 
 Androgen-Insensitivity Syndrome [MESH:D013734] (567)
 Hypospadias [MESH:D007021] (798) 
 Hypospadias 1, X-Linked [MESH:C567482] (571)
 Urogenital Neoplasms [MESH:D014565] (6932) 
 Genital Neoplasms, Male [MESH:D005834] (6224) 
 Prostatic Neoplasms [MESH:D011471] (6135)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7792) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Nephritis [MESH:D009393] (4236) 
 Nephritis, Interstitial [MESH:D009395] (1927)
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Lupus Nephritis [MESH:D008181] (602)
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770) 
 Glomerulopathy with fibronectin deposits [MESH:C536826] (244)
 Nephrosis [MESH:D009401] (2228) 
 Nephrotic Syndrome [MESH:D009404] (1536)
 Renal Insufficiency [MESH:D051437] (4951) 
 Acute Kidney Injury [MESH:D058186] (4142)
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Uremia [MESH:D014511] (2898) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Ureteral Diseases [MESH:D014515] (1024) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Urinary Bladder Diseases [MESH:D001745] (4374) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
C13. Female Urogenital Diseases and Pregnancy Complications 
C13. Female Urogenital Diseases and Pregnancy Complications
 Female Urogenital Diseases [MESH:D052776] (8724) 
 Genital Diseases, Female [MESH:D005831] (5563) 
 Adnexal Diseases [MESH:D000291] (4273) 
 Ovarian Diseases [MESH:D010049] (4255) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Sexually Transmitted Diseases [MESH:D012749] (1712) 
 Sexually Transmitted Diseases, Bacterial [MESH:D015231] (1711) 
 Chlamydia Infections [MESH:D002690] (1693)
 Uterine Diseases [MESH:D014591] (2479) 
 Uterine Neoplasms [MESH:D014594] (2430) 
 Endometrial Neoplasms [MESH:D016889] (1984)
 Urogenital Abnormalities [MESH:D014564] (2043) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XY Disorders of Sex Development [MESH:D058490] (1060) 
 Androgen-Insensitivity Syndrome [MESH:D013734] (567)
 Hypospadias [MESH:D007021] (798) 
 Hypospadias 1, X-Linked [MESH:C567482] (571)
 Urogenital Neoplasms [MESH:D014565] (5792) 
 Genital Neoplasms, Female [MESH:D005833] (3810) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Uterine Neoplasms [MESH:D014594] (2433) 
 Endometrial Neoplasms [MESH:D016889] (1989)
 Urologic Neoplasms [MESH:D014571] (5315) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Urologic Diseases [MESH:D014570] (7793) 
 Kidney Diseases [MESH:D007674] (7242) 
 Anuria [MESH:D001002] (833)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Kidney Neoplasms [MESH:D007680] (3966) 
 Carcinoma, Renal Cell [MESH:D002292] (2975)
 Nephritis [MESH:D009393] (4236) 
 Nephritis, Interstitial [MESH:D009395] (1927)
 Glomerulonephritis [MESH:D005921] (3758) 
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Glomerulosclerosis, Focal Segmental [MESH:D005923] (1754)
 Lupus Nephritis [MESH:D008181] (602)
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770) 
 Glomerulopathy with fibronectin deposits [MESH:C536826] (244)
 Nephrosis [MESH:D009401] (2228) 
 Nephrotic Syndrome [MESH:D009404] (1536)
 Renal Insufficiency [MESH:D051437] (4951) 
 Acute Kidney Injury [MESH:D058186] (4142)
 Renal Insufficiency, Chronic [MESH:D051436] (2931) 
 Kidney Failure, Chronic [MESH:D007676] (2930)
 Uremia [MESH:D014511] (2898) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Ureteral Diseases [MESH:D014515] (1024) 
 Ureteral Neoplasms [MESH:D014516] (574)
 Urinary Bladder Diseases [MESH:D001745] (4375) 
 Urinary Bladder Neoplasms [MESH:D001749] (4079)
 Urination Disorders [MESH:D014555] (3598) 
 Anuria [MESH:D001002] (833)
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
 Pregnancy Complications [MESH:D011248] (4768) 
 Abortion, Spontaneous [MESH:D000022] (2780)
 Diabetes, Gestational [MESH:D016640] (1157)
 Placenta Diseases [MESH:D010922] (1781)
 Pregnancy Complications, Cardiovascular [MESH:D011249] (1994)
 Prenatal Injuries [MESH:D049188] (1314)
 Fetal Diseases [MESH:D005315] (1206) 
 Fetal Growth Retardation [MESH:D005317] (986) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
C14. Cardiovascular Diseases 
C14. Cardiovascular Diseases
 Z. Exceptions (2667) 
 Not Fully Specified [NFS] (2667)
 Cardiovascular Diseases [MESH:D002318] (10123) 
 Pregnancy Complications, Cardiovascular [MESH:D011249] (1994)
 Cardiovascular Abnormalities [MESH:D018376] (3153) 
 Heart Defects, Congenital [MESH:D006330] (2447) 
 Marfan Syndrome [MESH:D008382] (646)
 Heart Diseases [MESH:D006331] (8614) 
 Heart Arrest [MESH:D006323] (1926)
 Heart Failure [MESH:D006333] (4058)
 Ventricular Dysfunction [MESH:D018754] (2348)
 Arrhythmias, Cardiac [MESH:D001145] (4679) 
 Tachycardia [MESH:D013610] (3339) 
 Tachycardia, Ventricular [MESH:D017180] (1386) 
 Torsades de Pointes [MESH:D016171] (880)
 Cardiomegaly [MESH:D006332] (4081) 
 Hypertrophy, Left Ventricular [MESH:D017379] (1430)
 Cardiomyopathies [MESH:D009202] (5331) 
 Diabetic Cardiomyopathies [MESH:D058065] (1995)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Myocarditis [MESH:D009205] (1708)
 Heart Defects, Congenital [MESH:D006330] (2443) 
 Marfan Syndrome [MESH:D008382] (646)
 Heart Valve Diseases [MESH:D006349] (3333) 
 Aortic Valve Insufficiency [MESH:D001022] (1002)
 Myocardial Ischemia [MESH:D017202] (5787) 
 Acute Coronary Syndrome [MESH:D054058] (2286)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Myocardial Stunning [MESH:D017682] (1816)
 Angina Pectoris [MESH:D000787] (2575) 
 Acute Coronary Syndrome [MESH:D054058] (2286)
 Angina, Unstable [MESH:D000789] (782)
 Angina, Stable [MESH:D060050] (1702)
 Coronary Disease [MESH:D003327] (3439) 
 Coronary Artery Disease [MESH:D003324] (2685)
 Coronary Stenosis [MESH:D023921] (1806) 
 Coronary Restenosis [MESH:D023903] (1683)
 Myocardial Infarction [MESH:D009203] (4122) 
 Myocardial Stunning [MESH:D017682] (1816)
 Vascular Diseases [MESH:D014652] (8691) 
 Angioedema [MESH:D000799] (837)
 Arteritis [MESH:D001167] (1084)
 Hyperemia [MESH:D006940] (2372)
 Hypertension [MESH:D006973] (5655)
 Hypotension [MESH:D007022] (4045)
 Peripheral Vascular Diseases [MESH:D016491] (1412)
 Vascular System Injuries [MESH:D057772] (2086)
 Aneurysm [MESH:D000783] (1886) 
 Aneurysm, Ruptured [MESH:D017542] (645) 
 Aortic Rupture [MESH:D001019] (637)
 Aortic Aneurysm [MESH:D001014] (1721) 
 Aortic Aneurysm, Abdominal [MESH:D017544] (1519)
 Aortic Aneurysm, Thoracic [MESH:D017545] (781)
 Aortic Rupture [MESH:D001019] (637)
 Aortic Diseases [MESH:D001018] (1737) 
 Aortic Aneurysm [MESH:D001014] (1721) 
 Aortic Aneurysm, Abdominal [MESH:D017544] (1519)
 Aortic Aneurysm, Thoracic [MESH:D017545] (781)
 Aortic Rupture [MESH:D001019] (637)
 Arterial Occlusive Diseases [MESH:D001157] (4520) 
 Arteriosclerosis [MESH:D001161] (4466) 
 Atherosclerosis [MESH:D050197] (4188)
 Coronary Artery Disease [MESH:D003324] (2685)
 Cerebrovascular Disorders [MESH:D002561] (5541) 
 Carotid Artery Diseases [MESH:D002340] (1993)
 Brain Ischemia [MESH:D002545] (4873) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Arterial Diseases [MESH:D020765] (2468) 
 Cerebral Arterial Diseases [MESH:D002539] (2440) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Intracranial Hemorrhages [MESH:D020300] (3269) 
 Cerebral Hemorrhage [MESH:D002543] (2873)
 Stroke [MESH:D020521] (3702) 
 Brain Infarction [MESH:D020520] (2571) 
 Cerebral Infarction [MESH:D002544] (2458) 
 Infarction, Middle Cerebral Artery [MESH:D020244] (2268)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Embolism and Thrombosis [MESH:D016769] (3374) 
 Thrombosis [MESH:D013927] (3101)
 Embolism [MESH:D004617] (1137) 
 Pulmonary Embolism [MESH:D011655] (1118)
 Hemostatic Disorders [MESH:D020141] (2894) 
 Multiple Myeloma [MESH:D009101] (2765)
 Myocardial Ischemia [MESH:D017202] (5791) 
 Acute Coronary Syndrome [MESH:D054058] (2286)
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Myocardial Stunning [MESH:D017682] (1816)
 Angina Pectoris [MESH:D000787] (2575) 
 Acute Coronary Syndrome [MESH:D054058] (2286)
 Angina, Unstable [MESH:D000789] (782)
 Angina, Stable [MESH:D060050] (1702)
 Coronary Disease [MESH:D003327] (3439) 
 Coronary Artery Disease [MESH:D003324] (2685)
 Coronary Stenosis [MESH:D023921] (1806) 
 Coronary Restenosis [MESH:D023903] (1683)
 Myocardial Infarction [MESH:D009203] (4151) 
 Myocardial Stunning [MESH:D017682] (1816)
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Vasculitis [MESH:D014657] (2604) 
 Arteritis [MESH:D001167] (1084)
 Behcet Syndrome [MESH:D001528] (1784)
C15. Hemic and Lymphatic Diseases 
C15. Hemic and Lymphatic Diseases
 Hematologic Diseases [MESH:D006402] (6174) 
 Methemoglobinemia [MESH:D008708] (850)
 Polycythemia [MESH:D011086] (412)
 Anemia [MESH:D000740] (3966) 
 Anemia, Refractory [MESH:D000753] (1567)
 Anemia, Aplastic [MESH:D000741] (1925) 
 Anemia, Hypoplastic, Congenital [MESH:D029502] (1665) 
 Fanconi Anemia [MESH:D005199] (1604)
 Anemia, Hemolytic [MESH:D000743] (3083) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Anemia, Hemolytic, Congenital [MESH:D000745] (2001) 
 Heinz Body Anemias [MESH:C563030] (127)
 Anemia, Sickle Cell [MESH:D000755] (1722)
 Thalassemia [MESH:D013789] (501) 
 alpha-Thalassemia [MESH:D017085] (176)
 beta-Thalassemia [MESH:D017086] (458)
 Hemoglobinuria, Paroxysmal [MESH:D006457] (293) 
 Glycosylphosphatidylinositol deficiency [MESH:C537277] (61)
 Anemia, Hypochromic [MESH:D000747] (616) 
 Anemia, hypochromic microcytic [MESH:C536357] (164)
 Blood Group Incompatibility [MESH:D001787] (277) 
 Erythroblastosis, Fetal [MESH:D004899] (275) 
 Kernicterus [MESH:D007647] (256)
 Blood Platelet Disorders [MESH:D001791] (3174) 
 Thrombocytopenia [MESH:D013921] (2966) 
 Thrombotic Microangiopathies [MESH:D057049] (2598) 
 Hemolytic-Uremic Syndrome [MESH:D006463] (2435)
 Blood Protein Disorders [MESH:D001796] (3051) 
 Hypoproteinemia [MESH:D007019] (1335) 
 Hypoalbuminemia [MESH:D034141] (1332)
 Paraproteinemias [MESH:D010265] (2781) 
 Multiple Myeloma [MESH:D009101] (2765)
 Bone Marrow Diseases [MESH:D001855] (2944) 
 Anemia, Aplastic [MESH:D000741] (1925) 
 Anemia, Hypoplastic, Congenital [MESH:D029502] (1665) 
 Fanconi Anemia [MESH:D005199] (1604)
 Myelodysplastic Syndromes [MESH:D009190] (2093) 
 Anemia, Refractory [MESH:D000753] (1567)
 Hemoglobinuria, Paroxysmal [MESH:D006457] (293) 
 Glycosylphosphatidylinositol deficiency [MESH:C537277] (61)
 Myeloproliferative Disorders [MESH:D009196] (1492) 
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive [MESH:D015464] (1032)
 Polycythemia Vera [MESH:D011087] (244)
 Hemoglobinopathies [MESH:D006453] (1863) 
 Anemia, Sickle Cell [MESH:D000755] (1722)
 Thalassemia [MESH:D013789] (511) 
 alpha-Thalassemia [MESH:D017085] (192)
 beta-Thalassemia [MESH:D017086] (458)
 Hemorrhagic Disorders [MESH:D006474] (3359) 
 Hemostatic Disorders [MESH:D020141] (2932) 
 Multiple Myeloma [MESH:D009101] (2765)
 Leukocyte Disorders [MESH:D007960] (2662) 
 Leukostasis [MESH:D018921] (769)
 Leukopenia [MESH:D007970] (1921) 
 Agranulocytosis [MESH:D000380] (1675) 
 Neutropenia [MESH:D009503] (1629)
 Phagocyte Bactericidal Dysfunction [MESH:D010585] (998) 
 Job Syndrome [MESH:D007589] (772)
 Lymphatic Diseases [MESH:D008206] (5167) 
 Splenic Diseases [MESH:D013158] (1323)
 Thymus Neoplasms [MESH:D013953] (247)
 Lymphoproliferative Disorders [MESH:D008232] (4638) 
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Lymphoma [MESH:D008223] (3684) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3330) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities 
C16. Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities [MESH:D009358] (12152) 
 Congenital Abnormalities [MESH:D000013] (8109) 
 Abnormalities, Drug-Induced [MESH:D000014] (1024)
 Abnormalities, Multiple [MESH:D000015] (3192) 
 Down Syndrome [MESH:D004314] (1287)
 Marfan Syndrome [MESH:D008382] (646)
 Cardiovascular Abnormalities [MESH:D018376] (3294) 
 Heart Defects, Congenital [MESH:D006330] (2611) 
 Marfan Syndrome [MESH:D008382] (646)
 Chromosome Disorders [MESH:D025063] (2030) 
 Down Syndrome [MESH:D004314] (1287)
 Eye Abnormalities [MESH:D005124] (1233) 
 Peters anomaly [MESH:C537884] (465)
 Coloboma [MESH:D003103] (315)
 Musculoskeletal Abnormalities [MESH:D009139] (3779) 
 Craniofacial Abnormalities [MESH:D019465] (3064) 
 Macrocephaly [MESH:D058627] (264) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Maxillofacial Abnormalities [MESH:D019767] (1448) 
 Jaw Abnormalities [MESH:D007569] (1435) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Microcephaly [MESH:D008831] (700) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Limb Deformities, Congenital [MESH:D017880] (1813) 
 Metaphyseal Anadysplasia 2 [MESH:C567771] (452)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
 Nervous System Malformations [MESH:D009421] (3354) 
 Neural Tube Defects [MESH:D009436] (2143)
 Hereditary Sensory and Motor Neuropathy [MESH:D015417] (899) 
 Charcot-Marie-Tooth Disease [MESH:D002607] (627) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Malformations of Cortical Development [MESH:D054220] (1406) 
 Neuronal Migration Disorders [MESH:D054081] (264)
 Tuberous Sclerosis [MESH:D014402] (635)
 Macrocephaly [MESH:D058627] (264) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Microcephaly [MESH:D008831] (700) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Skin Abnormalities [MESH:D012868] (1723) 
 Dyskeratosis Congenita [MESH:D019871] (185) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Stomatognathic System Abnormalities [MESH:D018640] (1705) 
 Maxillofacial Abnormalities [MESH:D019767] (1447) 
 Jaw Abnormalities [MESH:D007569] (1438) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Micrognathism [MESH:D008844] (230) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Mouth Abnormalities [MESH:D009056] (1383) 
 Cleft Palate [MESH:D002972] (1330) 
 Kniest dysplasia [MESH:C537207] (89)
 Urogenital Abnormalities [MESH:D014564] (2064) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XY Disorders of Sex Development [MESH:D058490] (1060) 
 Androgen-Insensitivity Syndrome [MESH:D013734] (567)
 Hypospadias [MESH:D007021] (798) 
 Hypospadias 1, X-Linked [MESH:C567482] (571)
 Fetal Diseases [MESH:D005315] (1205) 
 Fetal Growth Retardation [MESH:D005317] (986) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Genetic Diseases, Inborn [MESH:D030342] (9766) 
 Hyperthyroxinemia, Familial Dysalbuminemic [MESH:D050010] (478)
 Marfan Syndrome [MESH:D008382] (646)
 Anemia, Hemolytic, Congenital [MESH:D000745] (2001) 
 Heinz Body Anemias [MESH:C563030] (127)
 Anemia, Sickle Cell [MESH:D000755] (1722)
 Thalassemia [MESH:D013789] (501) 
 alpha-Thalassemia [MESH:D017085] (176)
 beta-Thalassemia [MESH:D017086] (458)
 Anemia, Hypoplastic, Congenital [MESH:D029502] (1665) 
 Fanconi Anemia [MESH:D005199] (1604)
 Chromosome Disorders [MESH:D025063] (2030) 
 Down Syndrome [MESH:D004314] (1287)
 Dwarfism [MESH:D004392] (783) 
 Kniest dysplasia [MESH:C537207] (89)
 Achondroplasia [MESH:D000130] (196) 
 Achondrogenesis type 2 [MESH:C536017] (89)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
 Eye Diseases, Hereditary [MESH:D015785] (1867) 
 Stickler Syndrome, Type I, Nonsyndromic Ocular [MESH:C563709] (89)
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Genetic Diseases, X-Linked [MESH:D040181] (3028) 
 Hypospadias 1, X-Linked [MESH:C567482] (571)
 Androgen-Insensitivity Syndrome [MESH:D013734] (567)
 Bulbo-Spinal Atrophy, X-Linked [MESH:D055534] (566) 
 Bulbospinal neuronopathy, X-linked recessive [MESH:C537017] (565)
 Dyskeratosis Congenita [MESH:D019871] (185) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Mental Retardation, X-Linked [MESH:D038901] (1867) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Hemoglobinopathies [MESH:D006453] (1863) 
 Anemia, Sickle Cell [MESH:D000755] (1722)
 Thalassemia [MESH:D013789] (511) 
 alpha-Thalassemia [MESH:D017085] (192)
 beta-Thalassemia [MESH:D017086] (458)
 Heredodegenerative Disorders, Nervous System [MESH:D020271] (3465) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Huntington Disease [MESH:D006816] (540)
 Tuberous Sclerosis [MESH:D014402] (635)
 Hereditary Sensory and Motor Neuropathy [MESH:D015417] (899) 
 Charcot-Marie-Tooth Disease [MESH:D002607] (627) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Mental Retardation, X-Linked [MESH:D038901] (1848) 
 Mental Retardation, X-Linked 93 [MESH:C567066] (12)
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Optic Atrophies, Hereditary [MESH:D015418] (1151) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Metabolism, Inborn Errors [MESH:D008661] (6032) 
 Coumarin Resistance [MESH:C563039] (397)
 Amino Acid Metabolism, Inborn Errors [MESH:D000592] (2565) 
 Hyperhomocysteinemia [MESH:D020138] (1724)
 Brain Diseases, Metabolic, Inborn [MESH:D020739] (2634) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Peroxisomal Disorders [MESH:D018901] (1472) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Carbohydrate Metabolism, Inborn Errors [MESH:D002239] (1100) 
 Glycogen Storage Disease [MESH:D006008] (530) 
 Glycogen Storage Disease XII [MESH:C562718] (98)
 Hyperbilirubinemia, Hereditary [MESH:D006933] (476) 
 Hyperbilirubinemia, Transient Familial Neonatal [MESH:C562692] (254)
 Gilbert Disease [MESH:D005878] (259)
 Crigler-Najjar Syndrome [MESH:D003414] (255) 
 Crigler Najjar syndrome, type 2 [MESH:C536213] (254)
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Metal Metabolism, Inborn Errors [MESH:D008664] (2017) 
 Congenital atransferrinemia [MESH:C538259] (145)
 Hemochromatosis [MESH:D006432] (1694)
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Peroxisomal Disorders [MESH:D018901] (1788) 
 Acatalasia [MESH:D020642] (788)
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Neoplastic Syndromes, Hereditary [MESH:D009386] (2578) 
 Tuberous Sclerosis [MESH:D014402] (635)
 Skin Diseases, Genetic [MESH:D012873] (3456) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Dyskeratosis Congenita [MESH:D019871] (185) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Infant, Newborn, Diseases [MESH:D007232] (3064) 
 Asphyxia Neonatorum [MESH:D001238] (1648)
 Erythroblastosis, Fetal [MESH:D004899] (257) 
 Kernicterus [MESH:D007647] (256)
 Hyperbilirubinemia, Neonatal [MESH:D051556] (469) 
 Hyperbilirubinemia, Transient Familial Neonatal [MESH:C562692] (254)
 Infant, Premature, Diseases [MESH:D007235] (1292) 
 Respiratory Distress Syndrome, Newborn [MESH:D012127] (169) 
 Hyaline Membrane Disease [MESH:D006819] (93) 
 Kniest dysplasia [MESH:C537207] (89)
 Thanatophoric Dysplasia [MESH:D013796] (147) 
 Platyspondylic Lethal Skeletal Dysplasia, Torrance Type [MESH:C563627] (89)
C17. Skin and Connective Tissue Diseases 
C17. Skin and Connective Tissue Diseases
 Connective Tissue Diseases [MESH:D003240] (4490) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Dermatomyositis [MESH:D003882] (1826)
 Marfan Syndrome [MESH:D008382] (646)
 Scleroderma, Localized [MESH:D012594] (1597)
 Collagen Diseases [MESH:D003095] (1267) 
 Kniest dysplasia [MESH:C537207] (89)
 Keloid [MESH:D007627] (1111)
 Lupus Erythematosus, Systemic [MESH:D008180] (2317) 
 Lupus Nephritis [MESH:D008181] (602)
 Rheumatic Diseases [MESH:D012216] (3619) 
 Arthritis, Rheumatoid [MESH:D001172] (3603)
 Skin Diseases [MESH:D012871] (8774) 
 Dermatomyositis [MESH:D003882] (1826)
 Keratosis [MESH:D007642] (1941)
 Scleroderma, Localized [MESH:D012594] (1597)
 Skin Neoplasms [MESH:D012878] (2991)
 Acneiform Eruptions [MESH:D017486] (1312) 
 Chloracne [MESH:D054506] (1274)
 Breast Diseases [MESH:D001941] (6148) 
 Breast Neoplasms [MESH:D001943] (6077) 
 Breast Neoplasms, Male [MESH:D018567] (650)
 Dermatitis [MESH:D003872] (4530) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Drug Eruptions [MESH:D003875] (2697) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Erythema [MESH:D004890] (1330) 
 Erythema Multiforme [MESH:D004892] (1185) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Facial Dermatoses [MESH:D005148] (1336) 
 Acneiform Eruptions [MESH:D017486] (1312) 
 Chloracne [MESH:D054506] (1274)
 Hair Diseases [MESH:D006201] (1891) 
 Hypotrichosis [MESH:D007039] (1513) 
 Alopecia [MESH:D000505] (1453)
 Skin Abnormalities [MESH:D012868] (1709) 
 Dyskeratosis Congenita [MESH:D019871] (185) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Skin Diseases, Eczematous [MESH:D017443] (3740) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Dermatitis, Contact [MESH:D003877] (3394) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Skin Diseases, Genetic [MESH:D012873] (3481) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Dyskeratosis Congenita [MESH:D019871] (185) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Skin Diseases, Infectious [MESH:D012874] (2684) 
 Skin Diseases, Parasitic [MESH:D012876] (2526) 
 Leishmaniasis [MESH:D007896] (2516) 
 Leishmaniasis, Cutaneous [MESH:D016773] (2359) 
 Leishmaniasis, Mucocutaneous [MESH:D007897] (606)
 Skin Diseases, Metabolic [MESH:D012875] (1574) 
 Lipodystrophy [MESH:D008060] (930) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Skin Diseases, Papulosquamous [MESH:D017444] (3392) 
 Lichenoid Eruptions [MESH:D017512] (1324)
 Parapsoriasis [MESH:D010267] (49)
 Psoriasis [MESH:D011565] (3278) 
 Arthritis, Psoriatic [MESH:D015535] (1859)
 Skin Diseases, Vascular [MESH:D017445] (3288) 
 Behcet Syndrome [MESH:D001528] (1784)
 Urticaria [MESH:D014581] (2668) 
 Angioedema [MESH:D000799] (837)
 Skin Diseases, Vesiculobullous [MESH:D012872] (1754) 
 Pemphigoid, Bullous [MESH:D010391] (707)
 Erythema Multiforme [MESH:D004892] (1185) 
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
C18. Nutritional and Metabolic Diseases 
C18. Nutritional and Metabolic Diseases
 Metabolic Diseases [MESH:D008659] (9025) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Brain Diseases, Metabolic [MESH:D001928] (3350) 
 Hepatic Encephalopathy [MESH:D006501] (1795)
 Kernicterus [MESH:D007647] (256)
 Brain Diseases, Metabolic, Inborn [MESH:D020739] (2634) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Peroxisomal Disorders [MESH:D018901] (1472) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Mitochondrial Encephalomyopathies [MESH:D017237] (158) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Calcium Metabolism Disorders [MESH:D002128] (3634) 
 Calcinosis [MESH:D002114] (2989)
 Hypercalcemia [MESH:D006934] (1999)
 DNA Repair-Deficiency Disorders [MESH:D049914] (2245) 
 Fanconi Anemia [MESH:D005199] (1604)
 Glucose Metabolism Disorders [MESH:D044882] (6122) 
 Hypoglycemia [MESH:D007003] (2420)
 Diabetes Mellitus [MESH:D003920] (5891) 
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 1 [MESH:D003922] (1897)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Diabetes, Gestational [MESH:D016640] (1152)
 Hyperglycemia [MESH:D006943] (1858) 
 Glucose Intolerance [MESH:D018149] (605)
 Hyperinsulinism [MESH:D006946] (3586) 
 Insulin Resistance [MESH:D007333] (3511) 
 Metabolic Syndrome X [MESH:D024821] (2151)
 Iron Metabolism Disorders [MESH:D019189] (2139) 
 Iron Overload [MESH:D019190] (1772) 
 Hemochromatosis [MESH:D006432] (1694)
 Lipid Metabolism Disorders [MESH:D052439] (3225) 
 Dyslipidemias [MESH:D050171] (2428) 
 Hyperlipidemias [MESH:D006949] (1908) 
 Hypercholesterolemia [MESH:D006937] (1404)
 Hyperlipoproteinemias [MESH:D006951] (903) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Lipodystrophy [MESH:D008060] (930) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Malabsorption Syndromes [MESH:D008286] (1869) 
 Hyperhomocysteinemia [MESH:D020138] (1716)
 Metabolism, Inborn Errors [MESH:D008661] (6028) 
 Coumarin Resistance [MESH:C563039] (397)
 Amino Acid Metabolism, Inborn Errors [MESH:D000592] (2559) 
 Hyperhomocysteinemia [MESH:D020138] (1724)
 Brain Diseases, Metabolic, Inborn [MESH:D020739] (2634) 
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Hereditary Central Nervous System Demyelinating Diseases [MESH:D020279] (1497) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Peroxisomal Disorders [MESH:D018901] (1472) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Carbohydrate Metabolism, Inborn Errors [MESH:D002239] (1100) 
 Glycogen Storage Disease [MESH:D006008] (530) 
 Glycogen Storage Disease XII [MESH:C562718] (98)
 Hyperbilirubinemia, Hereditary [MESH:D006933] (476) 
 Hyperbilirubinemia, Transient Familial Neonatal [MESH:C562692] (254)
 Gilbert Disease [MESH:D005878] (259)
 Crigler-Najjar Syndrome [MESH:D003414] (255) 
 Crigler Najjar syndrome, type 2 [MESH:C536213] (254)
 Lipid Metabolism, Inborn Errors [MESH:D008052] (2071) 
 Hyperlipoproteinemia Type II [MESH:D006938] (707)
 Lipidoses [MESH:D008064] (1655) 
 Neuronal Ceroid-Lipofuscinoses [MESH:D009472] (1026) 
 Ceroid lipofuscinosis, neuronal 1, infantile [MESH:C537948] (946)
 Metal Metabolism, Inborn Errors [MESH:D008664] (2017) 
 Congenital atransferrinemia [MESH:C538259] (145)
 Hemochromatosis [MESH:D006432] (1694)
 Hepatolenticular Degeneration [MESH:D006527] (473)
 Peroxisomal Disorders [MESH:D018901] (1788) 
 Acatalasia [MESH:D020642] (788)
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Refsum Disease [MESH:D012035] (173) 
 Neuropathy, hereditary motor and sensory, LOM type [MESH:C535716] (131)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Mitochondrial Diseases [MESH:D028361] (2561) 
 Optic Atrophy, Hereditary, Leber [MESH:D029242] (1100)
 Mitochondrial Myopathies [MESH:D017240] (2176) 
 Mitochondrial Encephalomyopathies [MESH:D017237] (1121) 
 Mitochondrial neurogastrointestinal encephalopathy syndrome [MESH:C537477] (71)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Proteostasis Deficiencies [MESH:D057165] (3522) 
 TDP-43 Proteinopathies [MESH:D057177] (3337) 
 Amyotrophic Lateral Sclerosis [MESH:D000690] (3296) 
 Amyotrophic lateral sclerosis 1 [MESH:C531617] (2559)
 Skin Diseases, Metabolic [MESH:D012875] (1574) 
 Lipodystrophy [MESH:D008060] (930) 
 Mandibuloacral dysplasia with type A lipodystrophy [MESH:C535705] (490)
 Porphyrias [MESH:D011164] (917) 
 Porphyrias, Hepatic [MESH:D017094] (881) 
 Porphyria Cutanea Tarda [MESH:D017119] (766)
 Wasting Syndrome [MESH:D019282] (1959) 
 HIV Wasting Syndrome [MESH:D019247] (1956)
 Water-Electrolyte Imbalance [MESH:D014883] (2790) 
 Hypercalcemia [MESH:D006934] (1999)
 Hyponatremia [MESH:D007010] (789)
 Nutrition Disorders [MESH:D009748] (4945) 
 Malnutrition [MESH:D044342] (2754) 
 Deficiency Diseases [MESH:D003677] (2742) 
 Protein Deficiency [MESH:D011488] (1057)
 Avitaminosis [MESH:D001361] (2304) 
 Vitamin A Deficiency [MESH:D014802] (705)
 Vitamin B Deficiency [MESH:D014804] (1817) 
 Hyperhomocysteinemia [MESH:D020138] (1716)
 Overnutrition [MESH:D044343] (4463) 
 Obesity [MESH:D009765] (4462)
 Wasting Syndrome [MESH:D019282] (1959) 
 HIV Wasting Syndrome [MESH:D019247] (1956)
C19. Endocrine System Diseases 
C19. Endocrine System Diseases
 Endocrine System Diseases [MESH:D004700] (8062) 
 Adrenal Gland Diseases [MESH:D000307] (2397) 
 Adrenal Insufficiency [MESH:D000309] (1599) 
 Adrenoleukodystrophy [MESH:D000326] (1348)
 Diabetes Mellitus [MESH:D003920] (6159) 
 Diabetes, Gestational [MESH:D016640] (1152)
 Diabetes Mellitus, Experimental [MESH:D003921] (4771)
 Diabetes Mellitus, Type 1 [MESH:D003922] (1897)
 Diabetes Mellitus, Type 2 [MESH:D003924] (4219)
 Diabetes Complications [MESH:D048909] (4129) 
 Diabetic Cardiomyopathies [MESH:D058065] (1995)
 Diabetic Nephropathies [MESH:D003928] (2301)
 Diabetic Neuropathies [MESH:D003929] (2443)
 Diabetic Angiopathies [MESH:D003925] (1984) 
 Diabetic Retinopathy [MESH:D003930] (1371)
 Dwarfism [MESH:D004392] (698) 
 Kniest dysplasia [MESH:C537207] (89)
 Endocrine Gland Neoplasms [MESH:D004701] (4925) 
 Ovarian Neoplasms [MESH:D010051] (3275)
 Pancreatic Neoplasms [MESH:D010190] (3820) 
 Pancreatic cancer, adult [MESH:C535836] (572)
 Carcinoma, Pancreatic Ductal [MESH:D021441] (1056)
 Gonadal Disorders [MESH:D006058] (5088) 
 Disorders of Sex Development [MESH:D012734] (1637) 
 46, XY Disorders of Sex Development [MESH:D058490] (1060) 
 Androgen-Insensitivity Syndrome [MESH:D013734] (567)
 Ovarian Diseases [MESH:D010049] (4253) 
 Ovarian Neoplasms [MESH:D010051] (3281)
 Thyroid Diseases [MESH:D013959] (2808) 
 Hyperthyroxinemia [MESH:D006981] (659) 
 Hyperthyroxinemia, Familial Dysalbuminemic [MESH:D050010] (478)
C20. Immune System Diseases 
C20. Immune System Diseases
 Z. Exceptions (350) 
 Not Fully Specified [NFS] (350)
 Immune System Diseases [MESH:D007154] (7674) 
 Graft vs Host Disease [MESH:D006086] (674)
 Autoimmune Diseases [MESH:D001327] (5067) 
 Arthritis, Rheumatoid [MESH:D001172] (3601)
 Diabetes Mellitus, Type 1 [MESH:D003922] (1893)
 Glomerulonephritis, Membranous [MESH:D015433] (642)
 Hepatitis, Autoimmune [MESH:D019693] (1982)
 Pemphigoid, Bullous [MESH:D010391] (707)
 Autoimmune Diseases of the Nervous System [MESH:D020274] (2238) 
 Demyelinating Autoimmune Diseases, CNS [MESH:D020278] (1732) 
 Multiple Sclerosis [MESH:D009103] (1716)
 Lupus Erythematosus, Systemic [MESH:D008180] (2317) 
 Lupus Nephritis [MESH:D008181] (602)
 Blood Group Incompatibility [MESH:D001787] (277) 
 Erythroblastosis, Fetal [MESH:D004899] (275) 
 Kernicterus [MESH:D007647] (256)
 Glomerulonephritis, Membranoproliferative [MESH:D015432] (770) 
 Glomerulopathy with fibronectin deposits [MESH:C536826] (244)
 Hypersensitivity [MESH:D006967] (5873) 
 Drug Hypersensitivity [MESH:D004342] (4000) 
 Drug Eruptions [MESH:D003875] (2695) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Hypersensitivity, Delayed [MESH:D006968] (3408) 
 Dermatitis, Allergic Contact [MESH:D017449] (3241)
 Hypersensitivity, Immediate [MESH:D006969] (4980) 
 Dermatitis, Atopic [MESH:D003876] (2052)
 Food Hypersensitivity [MESH:D005512] (608) 
 Peanut Hypersensitivity [MESH:D021183] (572)
 Respiratory Hypersensitivity [MESH:D012130] (4250) 
 Asthma [MESH:D001249] (3914)
 Rhinitis, Allergic, Perennial [MESH:D012221] (625)
 Urticaria [MESH:D014581] (2668) 
 Angioedema [MESH:D000799] (837)
 Immune Complex Diseases [MESH:D007105] (782) 
 Serum Sickness [MESH:D012713] (484)
 Immunologic Deficiency Syndromes [MESH:D007153] (3788) 
 HIV Infections [MESH:D015658] (3402) 
 Acquired Immunodeficiency Syndrome [MESH:D000163] (743)
 HIV Seropositivity [MESH:D006679] (480)
 HIV Wasting Syndrome [MESH:D019247] (1956)
 Phagocyte Bactericidal Dysfunction [MESH:D010585] (999) 
 Job Syndrome [MESH:D007589] (772)
 Immunoproliferative Disorders [MESH:D007160] (4761) 
 Lymphoproliferative Disorders [MESH:D008232] (4734) 
 Multiple Myeloma [MESH:D009101] (2767)
 Leukemia, Lymphoid [MESH:D007945] (3047) 
 Precursor Cell Lymphoblastic Leukemia-Lymphoma [MESH:D054198] (1754)
 Lymphoma [MESH:D008223] (3684) 
 Hodgkin Disease [MESH:D006689] (1082)
 Lymphoma, Non-Hodgkin [MESH:D008228] (3330) 
 Lymphoma, B-Cell [MESH:D016393] (2624) 
 Lymphoma, Large B-Cell, Diffuse [MESH:D016403] (2012)
 Paraproteinemias [MESH:D010265] (2791) 
 Multiple Myeloma [MESH:D009101] (2765)
C22. Animal Diseases 
C22. Animal Diseases
 Animal Diseases [MESH:D000820] (3656) 
 Disease Models, Animal [MESH:D004195] (2058)
 Mammary Neoplasms, Animal [MESH:D015674] (2735)
 Paratuberculosis [MESH:D010283] (427)
 Salmonella Infections, Animal [MESH:D012481] (604)
 Cattle Diseases [MESH:D002418] (416) 
 Tuberculosis, Bovine [MESH:D014380] (380)
C23. Pathological Conditions, Signs and Symptoms 
C23. Pathological Conditions, Signs and Symptoms
 Pathological Conditions, Anatomical [MESH:D020763] (6074) 
 Alopecia [MESH:D000505] (1383)
 Atrophy [MESH:D001284] (2603)
 Plaque, Atherosclerotic [MESH:D058226] (696)
 Hernia [MESH:D006547] (2825) 
 Hernia, Diaphragmatic [MESH:D006548] (2647)
 Intervertebral Disc Displacement [MESH:D007405] (520) 
 Intervertebral disc disease [MESH:C535531] (514)
 Hypertrophy [MESH:D006984] (4476) 
 Hepatomegaly [MESH:D006529] (1169)
 Splenomegaly [MESH:D013163] (1258)
 Cardiomegaly [MESH:D006332] (3802) 
 Hypertrophy, Left Ventricular [MESH:D017379] (1430)
 Pathologic Processes [MESH:D010335] (9863) 
 Chromosome Aberrations [MESH:D002869] (2352)
 Hyperplasia [MESH:D006965] (2463)
 Ischemia [MESH:D007511] (3049)
 Neointima [MESH:D058426] (814)
 Nerve Degeneration [MESH:D009410] (4061)
 Arrhythmias, Cardiac [MESH:D001145] (4658) 
 Tachycardia [MESH:D013610] (3339) 
 Tachycardia, Ventricular [MESH:D017180] (1386) 
 Torsades de Pointes [MESH:D016171] (880)
 Disease Attributes [MESH:D020969] (3654) 
 Disease Progression [MESH:D018450] (2868)
 Disease Susceptibility [MESH:D004198] (1200) 
 Genetic Predisposition to Disease [MESH:D020022] (966)
 Fibrosis [MESH:D005355] (3133) 
 Cicatrix [MESH:D002921] (1115) 
 Keloid [MESH:D007627] (1110)
 Growth Disorders [MESH:D006130] (2438) 
 Meier-Gorlin syndrome [MESH:C538012] (133)
 Fetal Growth Retardation [MESH:D005317] (986) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Hemorrhage [MESH:D006470] (4451) 
 Shock, Hemorrhagic [MESH:D012771] (2042)
 Gastrointestinal Hemorrhage [MESH:D006471] (815) 
 Peptic Ulcer Hemorrhage [MESH:D010438] (553)
 Intracranial Hemorrhages [MESH:D020300] (3241) 
 Cerebral Hemorrhage [MESH:D002543] (2872)
 Hyperbilirubinemia [MESH:D006932] (1860) 
 Kernicterus [MESH:D007647] (256)
 Hyperbilirubinemia, Neonatal [MESH:D051556] (258) 
 Hyperbilirubinemia, Transient Familial Neonatal [MESH:C562692] (254)
 Inflammation [MESH:D007249] (5241) 
 Neurogenic Inflammation [MESH:D020078] (2246)
 Systemic Inflammatory Response Syndrome [MESH:D018746] (3563) 
 Sepsis [MESH:D018805] (3562) 
 Shock, Septic [MESH:D012772] (1830)
 Necrosis [MESH:D009336] (4019) 
 Osteonecrosis [MESH:D010020] (537) 
 Femur Head Necrosis [MESH:D005271] (266)
 Neoplastic Processes [MESH:D009385] (5317) 
 Neoplasm Invasiveness [MESH:D009361] (3388)
 Neoplasm Metastasis [MESH:D009362] (4441)
 Neoplasm Recurrence, Local [MESH:D009364] (1949)
 Carcinogenesis [MESH:D063646] (3391) 
 Cell Transformation, Neoplastic [MESH:D002471] (3389)
 Postoperative Complications [MESH:D011183] (5311) 
 Reperfusion Injury [MESH:D015427] (4968) 
 Myocardial Reperfusion Injury [MESH:D015428] (3500)
 Shock [MESH:D012769] (2550) 
 Multiple Organ Failure [MESH:D009102] (1836)
 Shock, Hemorrhagic [MESH:D012771] (2042)
 Systemic Inflammatory Response Syndrome [MESH:D018746] (1832) 
 Shock, Septic [MESH:D012772] (1830)
 Signs and Symptoms [MESH:D012816] (10659) 
 Chills [MESH:D023341] (644)
 Cyanosis [MESH:D003490] (288)
 Edema [MESH:D004487] (3726)
 Body Temperature Changes [MESH:D001832] (3130) 
 Fever [MESH:D005334] (2856)
 Hypothermia [MESH:D007035] (2075)
 Body Weight [MESH:D001835] (4972) 
 Body Weight Changes [MESH:D001836] (3206) 
 Weight Gain [MESH:D015430] (2595)
 Weight Loss [MESH:D015431] (2512) 
 Emaciation [MESH:D004614] (2285) 
 Cachexia [MESH:D002100] (2283)
 Overweight [MESH:D050177] (4455) 
 Obesity [MESH:D009765] (4454)
 Neurologic Manifestations [MESH:D009461] (8702) 
 Seizures [MESH:D012640] (4502)
 Neurobehavioral Manifestations [MESH:D019954] (4706) 
 Memory Disorders [MESH:D008569] (3233)
 Communication Disorders [MESH:D003147] (2918) 
 Learning Disorders [MESH:D007859] (2727)
 Intellectual Disability [MESH:D008607] (1476) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Mental Retardation, Autosomal Recessive 7 [MESH:C567016] (29)
 Pain [MESH:D010146] (3869) 
 Pain, Intractable [MESH:D010148] (707)
 Neuralgia [MESH:D009437] (2074) 
 Neuralgia, Postherpetic [MESH:D051474] (742)
 Sensation Disorders [MESH:D012678] (5009) 
 Hearing Disorders [MESH:D006311] (2101) 
 Hearing Loss [MESH:D034381] (2066) 
 Hearing Loss, Conductive [MESH:D006314] (134) 
 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness [MESH:C565046] (89)
 Hearing Loss, Sensorineural [MESH:D006319] (1227) 
 Stickler syndrome, type 1 [MESH:C537492] (89)
 Deafness, Autosomal Dominant 20 [MESH:C565754] (69)
 Somatosensory Disorders [MESH:D020886] (4000) 
 Hyperalgesia [MESH:D006930] (3929)
 Pain [MESH:D010146] (4511) 
 Pain, Intractable [MESH:D010148] (707)
 Chest Pain [MESH:D002637] (2642) 
 Angina Pectoris [MESH:D000787] (2568) 
 Acute Coronary Syndrome [MESH:D054058] (2286)
 Angina, Unstable [MESH:D000789] (782)
 Angina, Stable [MESH:D060050] (1702)
 Neuralgia [MESH:D009437] (2074) 
 Neuralgia, Postherpetic [MESH:D051474] (742)
 Signs and Symptoms, Digestive [MESH:D012817] (3095) 
 Nausea [MESH:D009325] (2300)
 Vomiting [MESH:D014839] (1354)
 Signs and Symptoms, Respiratory [MESH:D012818] (2724) 
 Anoxia [MESH:D000860] (1698)
 Hyperoxia [MESH:D018496] (694)
 Hyperventilation [MESH:D006985] (652)
 Respiratory Sounds [MESH:D012135] (713)
 Urological Manifestations [MESH:D020924] (3532) 
 Proteinuria [MESH:D011507] (3293) 
 Albuminuria [MESH:D000419] (2394)
C24. Occupational Diseases 
C24. Occupational Diseases
 Z. Exceptions (1530) 
 Not Fully Specified [NFS] (1530)
 Occupational Diseases [MESH:D009784] (3402) 
 Pneumoconiosis [MESH:D011009] (2670) 
 Berylliosis [MESH:D001607] (2005)
 Silicosis [MESH:D012829] (1273)
C25. Chemically-Induced Disorders 
C25. Chemically-Induced Disorders
 Drug-Related Side Effects and Adverse Reactions [MESH:D064420] (5839) 
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Dyskinesia, Drug-Induced [MESH:D004409] (1389)
 Drug Hypersensitivity [MESH:D004342] (4001) 
 Drug Eruptions [MESH:D003875] (2697) 
 Serum Sickness [MESH:D012713] (484)
 Stevens-Johnson Syndrome [MESH:D013262] (1163)
 Poisoning [MESH:D011041] (6703) 
 Arsenic Poisoning [MESH:D020261] (2540)
 Drug-Induced Liver Injury [MESH:D056486] (4936)
 Lead Poisoning [MESH:D007855] (515)
 Manganese Poisoning [MESH:D020149] (2214)
 Organophosphate Poisoning [MESH:D062025] (497)
 Psychoses, Substance-Induced [MESH:D011605] (2053)
 Neurotoxicity Syndromes [MESH:D020258] (3323) 
 Dyskinesia, Drug-Induced [MESH:D004409] (1389)
 Substance-Related Disorders [MESH:D019966] (6308) 
 Amphetamine-Related Disorders [MESH:D019969] (2858)
 Cocaine-Related Disorders [MESH:D019970] (3054)
 Psychoses, Substance-Induced [MESH:D011605] (2052)
 Substance Withdrawal Syndrome [MESH:D013375] (2956)
 Alcohol-Related Disorders [MESH:D019973] (3869) 
 Alcoholism [MESH:D000437] (1519)
 Alcohol-Induced Disorders [MESH:D020751] (3350) 
 Liver Diseases, Alcoholic [MESH:D008108] (3243) 
 Hepatitis, Alcoholic [MESH:D006519] (1613)
 Liver Cirrhosis, Alcoholic [MESH:D008104] (3066)
 Opioid-Related Disorders [MESH:D009293] (1491) 
 Morphine Dependence [MESH:D009021] (855)
C26. Wounds and Injuries 
C26. Wounds and Injuries
 Z. Exceptions (2454) 
 Not Fully Specified [NFS] (2454)
 Wounds and Injuries [MESH:D014947] (5171) 
 Burns [MESH:D002056] (2565)
 Heat Stress Disorders [MESH:D018882] (226)
 Vascular System Injuries [MESH:D057772] (2086)
 Craniocerebral Trauma [MESH:D006259] (3523) 
 Brain Injuries [MESH:D001930] (3431)
 Radiation Injuries [MESH:D011832] (2718) 
 Radiation Injuries, Experimental [MESH:D011833] (2662)
 Rupture [MESH:D012421] (646) 
 Aortic Rupture [MESH:D001019] (637)
 Spinal Cord Injuries [MESH:D013119] (2688) 
 Spinal Cord Compression [MESH:D013117] (1800)
 Trauma, Nervous System [MESH:D020196] (3535) 
 Craniocerebral Trauma [MESH:D006259] (3507) 
 Brain Injuries [MESH:D001930] (3431)
D02. Organic Chemicals 
D02. Organic Chemicals
 Organic Chemicals [MESH:D009930] (75987) 
 Hydrocarbons [MESH:D006838] (35762) 
 Hydrocarbons, Cyclic [MESH:D006844] (22983) 
 Hydrocarbons, Aromatic [MESH:D006841] (19108) 
 Polycyclic Hydrocarbons, Aromatic [MESH:D011084] (8627) 
 Pyrenes [MESH:D011721] (369)
D04. Polycyclic Compounds 
D04. Polycyclic Compounds
 Polycyclic Compounds [MESH:D011083] (22048) 
 Polycyclic Hydrocarbons, Aromatic [MESH:D011084] (9200) 
 Pyrenes [MESH:D011721] (369)
F. Psychiatry and Psychology 
F. Psychiatry and Psychology
 Behavior and Behavior Mechanisms [MESH:D001520] (1594) 
 Neurobehavioral Manifestations [MESH:D019954] (1206) 
 Intellectual Disability [MESH:D008607] (1109) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Mental Retardation, Autosomal Recessive 7 [MESH:C567016] (29)
 Mental Disorders [MESH:D001523] (2063) 
 Mental Disorders Diagnosed in Childhood [MESH:D019952] (1245) 
 Intellectual Disability [MESH:D008607] (1109) 
 Hoyeraal Hreidarsson syndrome [MESH:C536068] (154)
 Mental Retardation, Autosomal Recessive 7 [MESH:C567016] (29)